Quantitative description of loss of clinical benefit following withdrawal of levodopa–carbidopa and bromocriptine in early Parkinson's disease
Identifieur interne : 004316 ( Main/Exploration ); précédent : 004315; suivant : 004317Quantitative description of loss of clinical benefit following withdrawal of levodopa–carbidopa and bromocriptine in early Parkinson's disease
Auteurs : Robert A. Hauser [États-Unis] ; Nicholas H. G. Holford [Nouvelle-Zélande]Source :
- Movement Disorders [ 0885-3185 ] ; 2002-09.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Analyse quantitative, Homme.
English descriptors
- KwdEn :
- Activities of Daily Living, Aged, Antiparkinson agent, Bromocriptine, Bromocriptine (therapeutic use), Carbidopa, Carbidopa (therapeutic use), Chemotherapy, Double-Blind Method, Drug Therapy, Combination, Early, Ergot derivatives, Female, Human, Humans, Levodopa, Levodopa (therapeutic use), Male, Models, Parkinson Disease (drug therapy), Parkinson disease, Parkinson's disease, Prospective Studies, Quantitative analysis, Treatment, Treatment withdrawal, Withholding Treatment, bromocriptine, disease progress, levodopa–carbidopa, long duration response, neuroprotection, quantitative model, selegiline, washout.
- MESH :
- chemical , therapeutic use : Bromocriptine, Carbidopa, Levodopa.
- drug therapy : Parkinson Disease.
- Activities of Daily Living, Aged, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Male, Prospective Studies, Withholding Treatment.
Abstract
In Parkinson's disease, effects of medications on the progression of the underlying disease can be assessed clinically by evaluating patients at baseline prior to treatment and at endpoint following medication washout. With this design, it is critical to employ a washout of sufficient duration to ensure elimination of all symptomatic effects. To assess the time course of resolution of symptomatic effects, we evaluated 31 patients with early Parkinson's disease for 2 weeks following discontinuation of levodopa–carbidopa and bromocriptine after 14 months of treatment. Patients had previously been randomly assigned to treatment with selegiline or placebo, and these had been discontinued 2 months earlier. Data from 20 patients with a clear washout of clinical benefit were used to investigate quantitative models describing the time course of total (Activities of Daily Living + motor) Unified Parkinson's Disease Rating Scale score change. The mean half‐life of loss of clinical benefit was 7.9 days (95% confidence interval, 2.2–30.4 days). This indicates that a washout period of 32 days (4 half‐lives) may be required to eliminate approximately 90% of the long‐term symptomatic effects of levodopa–carbidopa and bromocriptine following their withdrawal from patients with early Parkinson's disease. © 2002 Movement Disorder Society
Url:
DOI: 10.1002/mds.10226
Affiliations:
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Le document en format XML
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<term>Aged</term>
<term>Antiparkinson agent</term>
<term>Bromocriptine</term>
<term>Bromocriptine (therapeutic use)</term>
<term>Carbidopa</term>
<term>Carbidopa (therapeutic use)</term>
<term>Chemotherapy</term>
<term>Double-Blind Method</term>
<term>Drug Therapy, Combination</term>
<term>Early</term>
<term>Ergot derivatives</term>
<term>Female</term>
<term>Human</term>
<term>Humans</term>
<term>Levodopa</term>
<term>Levodopa (therapeutic use)</term>
<term>Male</term>
<term>Models</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Prospective Studies</term>
<term>Quantitative analysis</term>
<term>Treatment</term>
<term>Treatment withdrawal</term>
<term>Withholding Treatment</term>
<term>bromocriptine</term>
<term>disease progress</term>
<term>levodopa–carbidopa</term>
<term>long duration response</term>
<term>neuroprotection</term>
<term>quantitative model</term>
<term>selegiline</term>
<term>washout</term>
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<term>Carbidopa</term>
<term>Levodopa</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term>
<term>Aged</term>
<term>Double-Blind Method</term>
<term>Drug Therapy, Combination</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Prospective Studies</term>
<term>Withholding Treatment</term>
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<term>Antiparkinsonien</term>
<term>Arrêt traitement</term>
<term>Bromocriptine</term>
<term>Carbidopa</term>
<term>Chimiothérapie</term>
<term>Ergot dérivé</term>
<term>Homme</term>
<term>Lévodopa</term>
<term>Modèle</term>
<term>Parkinson maladie</term>
<term>Précoce</term>
<term>Traitement</term>
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<front><div type="abstract" xml:lang="en">In Parkinson's disease, effects of medications on the progression of the underlying disease can be assessed clinically by evaluating patients at baseline prior to treatment and at endpoint following medication washout. With this design, it is critical to employ a washout of sufficient duration to ensure elimination of all symptomatic effects. To assess the time course of resolution of symptomatic effects, we evaluated 31 patients with early Parkinson's disease for 2 weeks following discontinuation of levodopa–carbidopa and bromocriptine after 14 months of treatment. Patients had previously been randomly assigned to treatment with selegiline or placebo, and these had been discontinued 2 months earlier. Data from 20 patients with a clear washout of clinical benefit were used to investigate quantitative models describing the time course of total (Activities of Daily Living + motor) Unified Parkinson's Disease Rating Scale score change. The mean half‐life of loss of clinical benefit was 7.9 days (95% confidence interval, 2.2–30.4 days). This indicates that a washout period of 32 days (4 half‐lives) may be required to eliminate approximately 90% of the long‐term symptomatic effects of levodopa–carbidopa and bromocriptine following their withdrawal from patients with early Parkinson's disease. © 2002 Movement Disorder Society</div>
</front>
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<tree><country name="États-Unis"><region name="Floride"><name sortKey="Hauser, Robert A" sort="Hauser, Robert A" uniqKey="Hauser R" first="Robert A." last="Hauser">Robert A. Hauser</name>
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