[123I]β-CIT SPECT in multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration
Identifieur interne : 004B71 ( Main/Exploration ); précédent : 004B70; suivant : 004B72[123I]β-CIT SPECT in multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration
Auteurs : Walter Pirker [Autriche] ; Susanne Asenbaum [Autriche] ; Gerhard Bencsits [Autriche] ; Daniela Prayer [Autriche] ; Willibald Gerschlager [Autriche] ; Lüder Deecke [Autriche] ; Thomas Brücke [Autriche]Source :
- Movement disorders [ 0885-3185 ] ; 2000.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Adulte.
English descriptors
- KwdEn :
Abstract
Differentiation between Parkinson's disease (PD) and other neurodegenerative disorders with parkinsonian features, such as multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD), is difficult on clinical grounds. We studied the pattern of dopaminergic degeneration in 18 patients with probable MSA, 8 patients with PSP, 4 patients with CBD, 48 patients with PD and a similar degree of disability, and 14 control subjects performing single photon emission computed tomography (SPECT) 20 hours after injection of [123I]β-CIT. Overall striatal binding was significantly reduced in MSA (-51% of normal mean), PSP (-60%), CBD (-35%), and PD (-58%), without overlap with control values. Asymmetry of striatal β-CIT binding was significantly increased in patients with CBD and PD, as compared with control subjects. Although asymmetry seemed to be less pronounced in MSA and PSP than in PD, this was not statistically significant. Putamen-caudate nucleus ratios in patients with PD, MSA, and PSP, but not with CBD, were significantly reduced, as compared with control subjects. In conclusion, [123I]β-CIT SPECT reliably enables the visualization of the presynaptic dopaminergic lesion in patients with MSA, PSP, and CBD. In most patients, however, it does not seem to be possible to differentiate these disorders from PD with this method.
Affiliations:
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I]β-CIT SPECT in multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">[<sup>123</sup>
I]β-CIT SPECT in multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration</title>
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<author><name sortKey="Prayer, Daniela" sort="Prayer, Daniela" uniqKey="Prayer D" first="Daniela" last="Prayer">Daniela Prayer</name>
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<author><name sortKey="Gerschlager, Willibald" sort="Gerschlager, Willibald" uniqKey="Gerschlager W" first="Willibald" last="Gerschlager">Willibald Gerschlager</name>
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<author><name sortKey="Brucke, Thomas" sort="Brucke, Thomas" uniqKey="Brucke T" first="Thomas" last="Brücke">Thomas Brücke</name>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Basal ganglion</term>
<term>Cerebral cortex</term>
<term>Comparative study</term>
<term>Degeneration</term>
<term>Differential diagnostic</term>
<term>Dopaminergic neuron</term>
<term>Emission tomography</term>
<term>Multiple system atrophy</term>
<term>Parkinson disease</term>
<term>Photon</term>
<term>Supranuclear ophthalmoplegia</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Ophtalmoplégie supranucléaire</term>
<term>Atrophie multisystématisée</term>
<term>Parkinson maladie</term>
<term>Dégénérescence</term>
<term>Cortex cérébral</term>
<term>Noyau gris central</term>
<term>Tomoscintigraphie</term>
<term>Photon</term>
<term>Neurone dopaminergique</term>
<term>Diagnostic différentiel</term>
<term>Etude comparative</term>
<term>Adulte</term>
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<front><div type="abstract" xml:lang="en">Differentiation between Parkinson's disease (PD) and other neurodegenerative disorders with parkinsonian features, such as multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD), is difficult on clinical grounds. We studied the pattern of dopaminergic degeneration in 18 patients with probable MSA, 8 patients with PSP, 4 patients with CBD, 48 patients with PD and a similar degree of disability, and 14 control subjects performing single photon emission computed tomography (SPECT) 20 hours after injection of [<sup>123</sup>
I]β-CIT. Overall striatal binding was significantly reduced in MSA (-51% of normal mean), PSP (-60%), CBD (-35%), and PD (-58%), without overlap with control values. Asymmetry of striatal β-CIT binding was significantly increased in patients with CBD and PD, as compared with control subjects. Although asymmetry seemed to be less pronounced in MSA and PSP than in PD, this was not statistically significant. Putamen-caudate nucleus ratios in patients with PD, MSA, and PSP, but not with CBD, were significantly reduced, as compared with control subjects. In conclusion, [<sup>123</sup>
I]β-CIT SPECT reliably enables the visualization of the presynaptic dopaminergic lesion in patients with MSA, PSP, and CBD. In most patients, however, it does not seem to be possible to differentiate these disorders from PD with this method.</div>
</front>
</TEI>
<affiliations><list><country><li>Autriche</li>
</country>
<region><li>Vienne (Autriche)</li>
</region>
<settlement><li>Vienne (Autriche)</li>
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<tree><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Pirker, Walter" sort="Pirker, Walter" uniqKey="Pirker W" first="Walter" last="Pirker">Walter Pirker</name>
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<name sortKey="Asenbaum, Susanne" sort="Asenbaum, Susanne" uniqKey="Asenbaum S" first="Susanne" last="Asenbaum">Susanne Asenbaum</name>
<name sortKey="Asenbaum, Susanne" sort="Asenbaum, Susanne" uniqKey="Asenbaum S" first="Susanne" last="Asenbaum">Susanne Asenbaum</name>
<name sortKey="Bencsits, Gerhard" sort="Bencsits, Gerhard" uniqKey="Bencsits G" first="Gerhard" last="Bencsits">Gerhard Bencsits</name>
<name sortKey="Brucke, Thomas" sort="Brucke, Thomas" uniqKey="Brucke T" first="Thomas" last="Brücke">Thomas Brücke</name>
<name sortKey="Deecke, Luder" sort="Deecke, Luder" uniqKey="Deecke L" first="Lüder" last="Deecke">Lüder Deecke</name>
<name sortKey="Gerschlager, Willibald" sort="Gerschlager, Willibald" uniqKey="Gerschlager W" first="Willibald" last="Gerschlager">Willibald Gerschlager</name>
<name sortKey="Prayer, Daniela" sort="Prayer, Daniela" uniqKey="Prayer D" first="Daniela" last="Prayer">Daniela Prayer</name>
</country>
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</record>
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