Randomized trial of safinamide add-on to levodopa in Parkinson's disease with motor fluctuations
Identifieur interne : 000814 ( Main/Exploration ); précédent : 000813; suivant : 000815Randomized trial of safinamide add-on to levodopa in Parkinson's disease with motor fluctuations
Auteurs : Rupam Borgohain [Inde] ; J. Szasz [Roumanie] ; P. Stanzione [Italie] ; C. Meshram [Inde] ; M. Bhatt [Inde] ; D. Chirilineau [Roumanie] ; F. Stocchi [Italie] ; V. Lucini [Italie] ; R. Giuliani [Italie] ; E. Forrest [Italie] ; P. Rice [États-Unis] ; R. Anand [Suisse]Source :
- Movement Disorders [ 0885-3185 ] ; 2013.
English descriptors
- KwdEn :
- Activities of Daily Living, Aged, Alanine (analogs & derivatives), Alanine (therapeutic use), Antiparkinson Agents (therapeutic use), Benzylamines (therapeutic use), Dose-Response Relationship, Drug, Double-Blind Method, Female, Follow-Up Studies, Humans, Levodopa (therapeutic use), Male, Middle Aged, Motor Activity (drug effects), Motor Activity (radiation effects), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Severity of Illness Index.
- MESH :
- chemical , analogs & derivatives : Alanine.
- chemical , therapeutic use : Alanine, Antiparkinson Agents, Benzylamines, Levodopa.
- drug effects : Motor Activity.
- drug therapy : Parkinson Disease.
- physiopathology : Parkinson Disease.
- radiation effects : Motor Activity.
- Activities of Daily Living, Aged, Dose-Response Relationship, Drug, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Middle Aged, Severity of Illness Index.
Abstract
Levodopa is effective for the motor symptoms of Parkinson's disease (PD), but is associated with motor fluctuations and dyskinesia. Many patients require add-on therapy to improve motor fluctuations without exacerbating dyskinesia. The objective of this Phase III, multicenter, double-blind, placebo-controlled, parallel-group study was to evaluate the efficacy and safety of safinamide, an α-aminoamide with dopaminergic and nondopaminergic mechanisms, as add-on to
Url:
DOI: 10.1002/mds.25751
PubMed: 24323641
PubMed Central: 4285943
Affiliations:
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Le document en format XML
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<series><title level="j">Movement Disorders</title>
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<term>Antiparkinson Agents (therapeutic use)</term>
<term>Benzylamines (therapeutic use)</term>
<term>Dose-Response Relationship, Drug</term>
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<term>Antiparkinson Agents</term>
<term>Benzylamines</term>
<term>Levodopa</term>
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<front><div type="abstract" xml:lang="en"><p>Levodopa is effective for the motor symptoms of Parkinson's disease (PD), but is associated with motor fluctuations and dyskinesia. Many patients require add-on therapy to improve motor fluctuations without exacerbating dyskinesia. The objective of this Phase III, multicenter, double-blind, placebo-controlled, parallel-group study was to evaluate the efficacy and safety of safinamide, an α-aminoamide with dopaminergic and nondopaminergic mechanisms, as add-on to <sc>l</sc>
-dopa in the treatment of patients with PD and motor fluctuations. Patients were randomized to oral safinamide 100 mg/day (n = 224), 50 mg/day (n = 223), or placebo (n = 222) for 24 weeks. The primary endpoint was total <italic>on</italic>
time with no or nontroublesome dyskinesia (assessed using the Hauser patient diaries). Secondary endpoints included <italic>off</italic>
time, Unified Parkinson's Disease Rating Scale (UPDRS) Part III (motor) scores, and Clinical Global Impression-Change (CGI-C). At week 24, mean ± SD increases in total <italic>on</italic>
time with no or nontroublesome dyskinesia were 1.36 ± 2.625 hours for safinamide 100 mg/day, 1.37 ± 2.745 hours for safinamide 50 mg/day, and 0.97 ± 2.375 hours for placebo. Least squares means differences in both safinamide groups were significantly higher versus placebo. Improvements in <italic>off</italic>
time, UPDRS Part III, and CGI-C were significantly greater in both safinamide groups versus placebo. There were no significant between-group differences for incidences of treatment-emergent adverse events (TEAEs) or TEAEs leading to discontinuation. The addition of safinamide 50 mg/day or 100 mg/day to <sc>l</sc>
-dopa in patients with PD and motor fluctuations significantly increased total <italic>on</italic>
time with no or nontroublesome dyskinesia, decreased <italic>off</italic>
time, and improved parkinsonism, indicating that safinamide improves motor symptoms and parkinsonism without worsening dyskinesia.</p>
</div>
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</author>
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<biblStruct><analytic><author><name sortKey="Hinson, Vk" uniqKey="Hinson V">VK Hinson</name>
</author>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Horstink, M" uniqKey="Horstink M">M Horstink</name>
</author>
<author><name sortKey="Tolosa, E" uniqKey="Tolosa E">E Tolosa</name>
</author>
<author><name sortKey="Bonuccelli, U" uniqKey="Bonuccelli U">U Bonuccelli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Blandini, F" uniqKey="Blandini F">F Blandini</name>
</author>
<author><name sortKey="Porter, Rh" uniqKey="Porter R">RH Porter</name>
</author>
<author><name sortKey="Greenamyre, Jt" uniqKey="Greenamyre J">JT Greenamyre</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chase, Tn" uniqKey="Chase T">TN Chase</name>
</author>
<author><name sortKey="Bibbiani, F" uniqKey="Bibbiani F">F Bibbiani</name>
</author>
<author><name sortKey="Oh, Jd" uniqKey="Oh J">JD Oh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pevarello, P" uniqKey="Pevarello P">P Pevarello</name>
</author>
<author><name sortKey="Bonsignori, A" uniqKey="Bonsignori A">A Bonsignori</name>
</author>
<author><name sortKey="Dostert, P" uniqKey="Dostert P">P Dostert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Caccia, C" uniqKey="Caccia C">C Caccia</name>
</author>
<author><name sortKey="Maj, R" uniqKey="Maj R">R Maj</name>
</author>
<author><name sortKey="Calabresi, M" uniqKey="Calabresi M">M Calabresi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Caccia, C" uniqKey="Caccia C">C Caccia</name>
</author>
<author><name sortKey="Salvati, P" uniqKey="Salvati P">P Salvati</name>
</author>
<author><name sortKey="Rossetti, S" uniqKey="Rossetti S">S Rossetti</name>
</author>
<author><name sortKey="Anand, R" uniqKey="Anand R">R Anand</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chazot, Pl" uniqKey="Chazot P">PL Chazot</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gregoire, L" uniqKey="Gregoire L">L Grégoire</name>
</author>
<author><name sortKey="Jourdain, Va" uniqKey="Jourdain V">VA Jourdain</name>
</author>
<author><name sortKey="Townsend, M" uniqKey="Townsend M">M Townsend</name>
</author>
<author><name sortKey="Roach, A" uniqKey="Roach A">A Roach</name>
</author>
<author><name sortKey="Di Paolo, T" uniqKey="Di Paolo T">T Di Paolo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Goetz, Cg" uniqKey="Goetz C">CG Goetz</name>
</author>
<author><name sortKey="Stebbins, Gt" uniqKey="Stebbins G">GT Stebbins</name>
</author>
<author><name sortKey="Shale, Hm" uniqKey="Shale H">HM Shale</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hauser, Ra" uniqKey="Hauser R">RA Hauser</name>
</author>
<author><name sortKey="Friedlander, J" uniqKey="Friedlander J">J Friedlander</name>
</author>
<author><name sortKey="Zesiewicz, Ta" uniqKey="Zesiewicz T">TA Zesiewicz</name>
</author>
</analytic>
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<author><name sortKey="Lehert, P" uniqKey="Lehert P">P Lehert</name>
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<author><name sortKey="Gruber Baldini, Al" uniqKey="Gruber Baldini A">AL Gruber-Baldini</name>
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<author><name sortKey="Anderson, Ke" uniqKey="Anderson K">KE Anderson</name>
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</author>
<author><name sortKey="Brooks, Dj" uniqKey="Brooks D">DJ Brooks</name>
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<author><name sortKey="Melamed, E" uniqKey="Melamed E">E Melamed</name>
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</author>
<author><name sortKey="Roach, A" uniqKey="Roach A">A Roach</name>
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<author><name sortKey="Di Paolo, T" uniqKey="Di Paolo T">T Di Paolo</name>
</author>
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</author>
<author><name sortKey="Bamfi, F" uniqKey="Bamfi F">F Bamfi</name>
</author>
</analytic>
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<author><name sortKey="Hauser, Ra" uniqKey="Hauser R">RA Hauser</name>
</author>
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<author><name sortKey="Fox, S" uniqKey="Fox S">S Fox</name>
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<author><name sortKey="Hauser, R" uniqKey="Hauser R">R Hauser</name>
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<author><name sortKey="Grassini, P" uniqKey="Grassini P">P Grassini</name>
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<author><name sortKey="De Pandis, Mf" uniqKey="De Pandis M">MF De Pandis</name>
</author>
<author><name sortKey="Battaglia, G" uniqKey="Battaglia G">G Battaglia</name>
</author>
<author><name sortKey="Cattaneo, C" uniqKey="Cattaneo C">C Cattaneo</name>
</author>
<author><name sortKey="Fariello, Rg" uniqKey="Fariello R">RG Fariello</name>
</author>
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<author><name sortKey="Onofrj, M" uniqKey="Onofrj M">M Onofrj</name>
</author>
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</author>
<author><name sortKey="Rossetti, S" uniqKey="Rossetti S">S Rossetti</name>
</author>
<author><name sortKey="Anand, R" uniqKey="Anand R">R Anand</name>
</author>
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<biblStruct><analytic><author><name sortKey="Stocchi, F" uniqKey="Stocchi F">F Stocchi</name>
</author>
<author><name sortKey="Borgohain, R" uniqKey="Borgohain R">R Borgohain</name>
</author>
<author><name sortKey="Onofrj, M" uniqKey="Onofrj M">M Onofrj</name>
</author>
</analytic>
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</author>
<author><name sortKey="Lucini, V" uniqKey="Lucini V">V Lucini</name>
</author>
<author><name sortKey="Giuliani, R" uniqKey="Giuliani R">R Giuliani</name>
</author>
<author><name sortKey="Rossetti, S" uniqKey="Rossetti S">S Rossetti</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Schapira, Ah" uniqKey="Schapira A">AH Schapira</name>
</author>
<author><name sortKey="Borgohain, R" uniqKey="Borgohain R">R Borgohain</name>
</author>
<author><name sortKey="Stocchi, F" uniqKey="Stocchi F">F Stocchi</name>
</author>
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<biblStruct><analytic><author><name sortKey="Barone, P" uniqKey="Barone P">P Barone</name>
</author>
<author><name sortKey="Fernandez, J" uniqKey="Fernandez J">J Fernandez</name>
</author>
<author><name sortKey="Ferreira, Jj" uniqKey="Ferreira J">JJ Ferreira</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stocchi, F" uniqKey="Stocchi F">F Stocchi</name>
</author>
<author><name sortKey="Borgohain, R" uniqKey="Borgohain R">R Borgohain</name>
</author>
<author><name sortKey="Onofrj, M" uniqKey="Onofrj M">M Onofrj</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schapira, Ah" uniqKey="Schapira A">AH Schapira</name>
</author>
<author><name sortKey="Stocchi, F" uniqKey="Stocchi F">F Stocchi</name>
</author>
<author><name sortKey="Borgohain, R" uniqKey="Borgohain R">R Borgohain</name>
</author>
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<affiliations><list><country><li>Inde</li>
<li>Italie</li>
<li>Roumanie</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region><li>Illinois</li>
</region>
</list>
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<name sortKey="Bhatt, M" sort="Bhatt, M" uniqKey="Bhatt M" first="M" last="Bhatt">M. Bhatt</name>
<name sortKey="Meshram, C" sort="Meshram, C" uniqKey="Meshram C" first="C" last="Meshram">C. Meshram</name>
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<name sortKey="Forrest, E" sort="Forrest, E" uniqKey="Forrest E" first="E" last="Forrest">E. Forrest</name>
<name sortKey="Giuliani, R" sort="Giuliani, R" uniqKey="Giuliani R" first="R" last="Giuliani">R. Giuliani</name>
<name sortKey="Lucini, V" sort="Lucini, V" uniqKey="Lucini V" first="V" last="Lucini">V. Lucini</name>
<name sortKey="Stocchi, F" sort="Stocchi, F" uniqKey="Stocchi F" first="F" last="Stocchi">F. Stocchi</name>
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<country name="États-Unis"><region name="Illinois"><name sortKey="Rice, P" sort="Rice, P" uniqKey="Rice P" first="P" last="Rice">P. Rice</name>
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<country name="Suisse"><noRegion><name sortKey="Anand, R" sort="Anand, R" uniqKey="Anand R" first="R" last="Anand">R. Anand</name>
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