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Paroxysmal dyskinesias in mice

Identifieur interne : 002702 ( Main/Exploration ); précédent : 002701; suivant : 002703

Paroxysmal dyskinesias in mice

Auteurs : Thomas L. Shirley [États-Unis] ; Lekha M. Rao [États-Unis] ; Ellen J. Hess [États-Unis] ; H. A. Jinnah [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2008-01-30.

RBID : ISTEX:BC5FF097585FB0A2A2D5F037E0FDF67F796B3BB5

Descripteurs français

Pascal (Inist)
- Animal, Dyskinésie, Dystonie, Pathologie du système nerveux, Souris.

English descriptors

KwdEn :
- Age Factors, Animal, Animals, Behavior, Animal, Chorea (genetics), Chorea (physiopathology), Disease Models, Animal, Dyskinesia, Dystonia, Mice, Mice, Inbred C57BL, Mice, Neurologic Mutants, Mouse, Nervous system diseases, Severity of Illness Index, channelopathy, dystonia, lethargic, paroxysmal dyskinesia, rocker, tottering.
MESH :
- genetics : Chorea.
- physiopathology : Chorea.
- Age Factors, Animals, Behavior, Animal, Disease Models, Animal, Mice, Mice, Inbred C57BL, Mice, Neurologic Mutants, Severity of Illness Index.

Abstract

Animal models of human disease are important tools for revealing the underlying mechanisms of pathophysiology and developing therapeutic strategies. Several unique mouse calcium channel mutants have been identified with nonepileptic, episodic dyskinetic movements that are phenotypically similar to human paroxysmal dyskinesias. In this report, video demonstrations of these motor attacks are provided for two previously described mouse mutants, tottering and lethargic, as well as a new one, rocker. Semiquantitative comparisons using two different rating scales reveal differences in attack morphology, severity, and duration among the strains. These mice provide three independent models of paroxysmal dyskinesia and support for prior proposals that channelopathies may underlie the human disorders. © 2007 Movement Disorder Society

Url:

DOI: 10.1002/mds.21829

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Animal models of human disease are important tools for revealing the underlying mechanisms of pathophysiology and developing therapeutic strategies. Several unique mouse calcium channel mutants have been identified with nonepileptic, episodic dyskinetic movements that are phenotypically similar to human paroxysmal dyskinesias. In this report, video demonstrations of these motor attacks are provided for two previously described mouse mutants, tottering and lethargic, as well as a new one, rocker. Semiquantitative comparisons using two different rating scales reveal differences in attack morphology, severity, and duration among the strains. These mice provide three independent models of paroxysmal dyskinesia and support for prior proposals that channelopathies may underlie the human disorders. © 2007 Movement Disorder Society</div>
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Movement Disorders (revue)

Paroxysmal dyskinesias in mice

Paroxysmal dyskinesias in mice

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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