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Abnormal cortical sensory activation in dystonia: An fMRI study

Identifieur interne : 004191 ( Main/Exploration ); précédent : 004190; suivant : 004192

Abnormal cortical sensory activation in dystonia: An fMRI study

Auteurs : Stephen Butterworth [Royaume-Uni] ; Sue Francis [Royaume-Uni] ; Edward Kelly [États-Unis] ; Francis Mcglone [Royaume-Uni] ; Richard Bowtell [Royaume-Uni] ; Guy V. Sawle [Royaume-Uni]

Source :

Movement Disorders [ 0885-3185 ] ; 2003-06.

RBID : ISTEX:B40AAA7C98B9A5469C2AFB5F40C07BB1DE27D561

Descripteurs français

Pascal (Inist)
- Analyse fonctionnelle, Cortex somatosensoriel, Dystonie, Homme, Imagerie RMN, Lésion focale, Physiopathologie.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Adolescent, Adult, Aged, Case-Control Studies, Cerebral Cortex (physiopathology), Dystonia, Dystonia (diagnosis), Dystonia (physiopathology), Female, Focal lesion, Functional analysis, Human, Humans, Image Processing, Computer-Assisted (methods), Magnetic Resonance Imaging (methods), Male, Middle Aged, Nuclear magnetic resonance imaging, Pathophysiology, Physical Stimulation (methods), Somatosensory Cortex (physiopathology), Somatosensory cortex, Touch, Vibration, fMRI, focal dystonia, secondary somatosensory cortex, somatosensation, vibrotaction.
MESH :
- diagnosis : Dystonia.
- methods : Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Physical Stimulation.
- physiopathology : Cerebral Cortex, Dystonia, Somatosensory Cortex.
- Adolescent, Adult, Aged, Case-Control Studies, Female, Humans, Male, Middle Aged, Touch, Vibration.

Abstract

Despite the obvious motor manifestations of focal dystonia, it is recognised that the sensory system plays an important role in this condition. This functional magnetic resonance imaging study examines the sensory representations of individual digits both within the subregions of the primary sensory cortex (SI) and in other nonprimary sensory areas. Patients with focal dystonia and controls were scanned during vibrotactile stimulation of both the index (digit 2) and little (digit 5) fingers of their dominant hand (which was the affected hand in all the dystonic subjects). The activation maps obtained were analysed for location, size, and magnitude of activation and three‐dimensional (3‐D) orientation of digit representations. Data from both groups were compared. There were significant differences in the average 3‐D separation between the two digit representations in area 1 of SI between subject groups (9.6 ± 1.2 mm for controls and 4.1 ± 0.2 mm for dystonic subjects). There were also strong trends for reversed ordering of the representation of the two digits in both the secondary sensory cortex and posterior parietal area between the two groups. In addition, in dystonic subjects, there was significant under activation in the secondary somatosensory cortex (SII/area 40) for both digits and in the posterior parietal area for digit 5. These results indicate the presence of widespread activation abnormalities in the cortical sensory system in dystonia. © 2003 Movement Disorder Society

Url:

https://api.istex.fr/document/B40AAA7C98B9A5469C2AFB5F40C07BB1DE27D561/fulltext/pdf

DOI: 10.1002/mds.10416

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Despite the obvious motor manifestations of focal dystonia, it is recognised that the sensory system plays an important role in this condition. This functional magnetic resonance imaging study examines the sensory representations of individual digits both within the subregions of the primary sensory cortex (SI) and in other nonprimary sensory areas. Patients with focal dystonia and controls were scanned during vibrotactile stimulation of both the index (digit 2) and little (digit 5) fingers of their dominant hand (which was the affected hand in all the dystonic subjects). The activation maps obtained were analysed for location, size, and magnitude of activation and three‐dimensional (3‐D) orientation of digit representations. Data from both groups were compared. There were significant differences in the average 3‐D separation between the two digit representations in area 1 of SI between subject groups (9.6 ± 1.2 mm for controls and 4.1 ± 0.2 mm for dystonic subjects). There were also strong trends for reversed ordering of the representation of the two digits in both the secondary sensory cortex and posterior parietal area between the two groups. In addition, in dystonic subjects, there was significant under activation in the secondary somatosensory cortex (SII/area 40) for both digits and in the posterior parietal area for digit 5. These results indicate the presence of widespread activation abnormalities in the cortical sensory system in dystonia. © 2003 Movement Disorder Society</div>
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Movement Disorders (revue)

Abnormal cortical sensory activation in dystonia: An fMRI study

Abnormal cortical sensory activation in dystonia: An fMRI study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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