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Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: An HPLC and ESR study

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Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: An HPLC and ESR study

Auteurs : David T. Dexter [Royaume-Uni] ; Anne E. Holley ; William D. Flitter ; Trevor F. Slater ; F. Raymund Wells [Royaume-Uni] ; Susan E. Daniel [Royaume-Uni] ; Andrew Lees (neurologue) [Royaume-Uni] ; Jenner [Royaume-Uni] ; C. David Marsden [Royaume-Uni]

Source :

Movement Disorders [ 0885-3185 ] ; 1994.

RBID : ISTEX:B1F20CCFF64050136C8999C916D0190F66415FAC

English descriptors

KwdEn :
- Chromatography, High Pressure Liquid, Electron Spin Resonance Spectroscopy, Female, Free Radicals, Free radical, Humans, Lipid Peroxidation (physiology), Lipid Peroxides (analysis), Lipid hydroperoxide, Lipid peroxidation, Male, Nerve Degeneration (physiology), Parkinson Disease (pathology), Parkinson's disease, Substantia Nigra (pathology).
MESH :
- chemical , analysis : Lipid Peroxides.
- chemical : Free Radicals.
- pathology : Parkinson Disease, Substantia Nigra.
- physiology : Lipid Peroxidation, Nerve Degeneration.
- Chromatography, High Pressure Liquid, Electron Spin Resonance Spectroscopy, Female, Humans, Male.

Abstract

Previous studies examining the involvement of oxidative stress in the substantia nigra in Parkinson's disease have measured terminal products of lipid peroxidation or the function of antioxidant defense systems. We report a more specific early marker of lipid peroxidation, lipid hydroperoxides, in a high‐performance liquid chromatography (HPLC) and electron spin resonance (ESR) investigation. HPLC‐chemiluminescent detection revealed two classes of lipid hydroperoxides in brain tissue extracts–free fatty acid hydroperoxides and cholesterol lipid hydroperoxides. Only cholesterol lipid hydroperoxides were consistently detected in all tissue extracts. Cholesterol lipid hydroperoxides had a 10‐fold increase in the Parkinson's disease substantia nigra compared to control subjects. ESR detection of radical degradation products, including those of lipid hydroperoxides, in nigral homogenates incubated with the spin trap N‐t‐butyl‐α‐phenyl nitrone (PBN) showed a marked variation in ESR signal between tissues. Despite the increased levels of lipid hydroperoxides in parkinsonian substantia nigra, there was no overall difference in ESR signal intensity between nigral tissues from controls and from patients with Parkinson's disease. The increased levels of an early component of the peroxidation chain in substantia nigra in Parkinson's disease support the hypothesis of a continuous toxic process involving oxygen radical activity. However, using previously frozen tissue, ESR evidence for increased radical formation could not be demonstrated.

Url:

DOI: 10.1002/mds.870090115

Affiliations:

Le document en format XML

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<author><name sortKey="Flitter, William D" sort="Flitter, William D" uniqKey="Flitter W" first="William D." last="Flitter">William D. Flitter</name>
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<author><name sortKey="Slater, Trevor F" sort="Slater, Trevor F" uniqKey="Slater T" first="Trevor F." last="Slater">Trevor F. Slater</name>
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<author><name sortKey="Wells, F Raymund" sort="Wells, F Raymund" uniqKey="Wells F" first="F. Raymund" last="Wells">F. Raymund Wells</name>
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<author><name sortKey="Daniel, Susan E" sort="Daniel, Susan E" uniqKey="Daniel S" first="Susan E." last="Daniel">Susan E. Daniel</name>
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<author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name>
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<term>Lipid Peroxides (analysis)</term>
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<term>Lipid peroxidation</term>
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<front><div type="abstract" xml:lang="en">Previous studies examining the involvement of oxidative stress in the substantia nigra in Parkinson's disease have measured terminal products of lipid peroxidation or the function of antioxidant defense systems. We report a more specific early marker of lipid peroxidation, lipid hydroperoxides, in a high‐performance liquid chromatography (HPLC) and electron spin resonance (ESR) investigation. HPLC‐chemiluminescent detection revealed two classes of lipid hydroperoxides in brain tissue extracts–free fatty acid hydroperoxides and cholesterol lipid hydroperoxides. Only cholesterol lipid hydroperoxides were consistently detected in all tissue extracts. Cholesterol lipid hydroperoxides had a 10‐fold increase in the Parkinson's disease substantia nigra compared to control subjects. ESR detection of radical degradation products, including those of lipid hydroperoxides, in nigral homogenates incubated with the spin trap N‐t‐butyl‐α‐phenyl nitrone (PBN) showed a marked variation in ESR signal between tissues. Despite the increased levels of lipid hydroperoxides in parkinsonian substantia nigra, there was no overall difference in ESR signal intensity between nigral tissues from controls and from patients with Parkinson's disease. The increased levels of an early component of the peroxidation chain in substantia nigra in Parkinson's disease support the hypothesis of a continuous toxic process involving oxygen radical activity. However, using previously frozen tissue, ESR evidence for increased radical formation could not be demonstrated.</div>
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Movement Disorders (revue)

Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: An HPLC and ESR study

Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: An HPLC and ESR study

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Abstract

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	Movement Disorders (revue)
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