[123I]β‐CIT single‐photon emission tomography in DOPA‐responsive dystonia
Identifieur interne : 005214 ( Main/Exploration ); précédent : 005213; suivant : 005215[123I]β‐CIT single‐photon emission tomography in DOPA‐responsive dystonia
Auteurs : Naumann [Allemagne] ; Walter Pirker [Allemagne] ; Karlheinz Reiners [Allemagne] ; Klaus Lange [Allemagne] ; Georg Becker [Allemagne] ; Thomas Brücke [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 1997-05.
English descriptors
- KwdEn :
- Adult, Aged, Binding Sites, Cerebellum (metabolism), Cerebellum (radionuclide imaging), Corpus Striatum (metabolism), Corpus Striatum (radionuclide imaging), DOPA‐responsive dystonia, Diagnosis, Differential, Dopamine (metabolism), Dopamine transporter, Dystonia (drug therapy), Dystonia (radionuclide imaging), FD PET, Female, Humans, Levodopa (therapeutic use), Middle Aged, Radioactive Tracers, SPECT, Tomography, Emission-Computed, Single-Photon.
- MESH :
- chemical , metabolism : Dopamine.
- drug therapy : Dystonia.
- metabolism : Cerebellum, Corpus Striatum.
- radionuclide imaging : Cerebellum, Corpus Striatum, Dystonia.
- chemical , therapeutic use : Levodopa.
- Adult, Aged, Binding Sites, Diagnosis, Differential, Female, Humans, Middle Aged, Radioactive Tracers, Tomography, Emission-Computed, Single-Photon.
Abstract
The radiotracer [123I]β‐CIT is a sensitive marker of dopamine uptake sites that can be used to visualize dopaminergic nerve endings in vivo in the human brain. We report on [123I]β‐CIT single‐photon emission computed tomography (SPECT) findings in a patient with DOPA‐responsive dystonia (DRD). [123I]β‐CIT SPECT showed a striatal radiotracer uptake in the upper range of normal, indicating intact dopamine transporters and structural integrity of nigrostriatal neurons. This differentiates DRD from clinically similar cases with juvenile‐onset parkinsonism with dystonia that have a considerably poorer prognosis. [123I]β‐CIT SPECT may provide a method equally as useful as fluorodopa positron emission tomography in DRD.
Url:
DOI: 10.1002/mds.870120330
Affiliations:
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<term>Cerebellum (metabolism)</term>
<term>Cerebellum (radionuclide imaging)</term>
<term>Corpus Striatum (metabolism)</term>
<term>Corpus Striatum (radionuclide imaging)</term>
<term>DOPA‐responsive dystonia</term>
<term>Diagnosis, Differential</term>
<term>Dopamine (metabolism)</term>
<term>Dopamine transporter</term>
<term>Dystonia (drug therapy)</term>
<term>Dystonia (radionuclide imaging)</term>
<term>FD PET</term>
<term>Female</term>
<term>Humans</term>
<term>Levodopa (therapeutic use)</term>
<term>Middle Aged</term>
<term>Radioactive Tracers</term>
<term>SPECT</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dystonia</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cerebellum</term>
<term>Corpus Striatum</term>
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<keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Cerebellum</term>
<term>Corpus Striatum</term>
<term>Dystonia</term>
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<term>Binding Sites</term>
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<front><div type="abstract" xml:lang="en">The radiotracer [123I]β‐CIT is a sensitive marker of dopamine uptake sites that can be used to visualize dopaminergic nerve endings in vivo in the human brain. We report on [123I]β‐CIT single‐photon emission computed tomography (SPECT) findings in a patient with DOPA‐responsive dystonia (DRD). [123I]β‐CIT SPECT showed a striatal radiotracer uptake in the upper range of normal, indicating intact dopamine transporters and structural integrity of nigrostriatal neurons. This differentiates DRD from clinically similar cases with juvenile‐onset parkinsonism with dystonia that have a considerably poorer prognosis. [123I]β‐CIT SPECT may provide a method equally as useful as fluorodopa positron emission tomography in DRD.</div>
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<name sortKey="Becker, Georg" sort="Becker, Georg" uniqKey="Becker G" first="Georg" last="Becker">Georg Becker</name>
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<name sortKey="Lange, Klaus" sort="Lange, Klaus" uniqKey="Lange K" first="Klaus" last="Lange">Klaus Lange</name>
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<name sortKey="Reiners, Karlheinz" sort="Reiners, Karlheinz" uniqKey="Reiners K" first="Karlheinz" last="Reiners">Karlheinz Reiners</name>
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