Visual and auditory evoked potentials in early onset parkinson's disease and their relationship to cerebrospinal fluid monoamine metabolites
Identifieur interne : 005D03 ( Main/Exploration ); précédent : 005D02; suivant : 005D04Visual and auditory evoked potentials in early onset parkinson's disease and their relationship to cerebrospinal fluid monoamine metabolites
Auteurs : Muthane [Inde, États-Unis] ; P. Satishchandra [Inde] ; M. N. Subhash [Inde]Source :
- Movement Disorders [ 0885-3185 ] ; 1993.
English descriptors
- KwdEn :
- Acoustic Stimulation, Adolescent, Adult, Aged, Early onset Parkinson's disease, Evoked Potentials, Auditory, Brain Stem, Evoked Potentials, Visual, Evoked potentials, Female, Homovanillic Acid (cerebrospinal fluid), Homovanillic Acid (metabolism), Humans, Hydroxyindoleacetic Acid (cerebrospinal fluid), Hydroxyindoleacetic Acid (metabolism), Juvenile parkinsonism, Male, Middle Aged, Monoamine metabolites, Parkinson Disease (cerebrospinal fluid), Parkinson Disease (diagnosis), Parkinson Disease (metabolism), Parkinson's disease, Photic Stimulation, Young onset Parkinson's disease.
- MESH :
- chemical , cerebrospinal fluid : Homovanillic Acid, Hydroxyindoleacetic Acid.
- chemical , metabolism : Homovanillic Acid, Hydroxyindoleacetic Acid.
- cerebrospinal fluid : Parkinson Disease.
- diagnosis : Parkinson Disease.
- metabolism : Parkinson Disease.
- Acoustic Stimulation, Adolescent, Adult, Aged, Evoked Potentials, Auditory, Brain Stem, Evoked Potentials, Visual, Female, Humans, Male, Middle Aged, Photic Stimulation.
Abstract
We studied visual (VEP) and brainstem auditory (BAEP) evoked potential changes in 23 patients with early onset Parkinson's disease (EOPD) to establish the nature of the changes as well as their relationship to dopaminergic (DA) and serotonergic (5‐HT) disturbances, as determined by cerebrospinal fuid levels of homovanillic acid (HVA) and 5‐hydroxyindoleacetic acid (5‐HIAA). We also compared these parameters between the young onset (YOPD) and juvenile Parkinsonism (JP), the two subgroups of EOPD, to look for any possible differences between the two. In EOPD, the mean P100 latency of the VEP was significantly prolonged compared to controls (p < 0.001). However, within EOPD the evoked potential parameters were not significantly different between YOPD and the JP subgroups. P100 latency was abnormal in six patients (YOPD: 5, JP:1) (26%). Six patients (YOPD: 3, JP:3) (26%) had abnormal BAEP. A significant negative correlation (r: −0.89, p <1%) was observed between the P100 latency and CSF HVA levels. No correlation was observed between the BAEP interpeak latencies and either CSF HVA or 5‐HIAA levels. This study suggests that VEP and BAEP abnormalities do occur in EOPD (in both YOPD and JP), and that the prolongation of P100 latency is secondary to DA deficiency as in PD. The cause of BAEP abnormalities in EOPD. There was no correlation between the VEP or BAEP changes to either the age at onset or duration of EOPD.
Url:
DOI: 10.1002/mds.870080316
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001992
- to stream Istex, to step Curation: 001992
- to stream Istex, to step Checkpoint: 003F70
- to stream PubMed, to step Corpus: 004C26
- to stream PubMed, to step Curation: 004C26
- to stream PubMed, to step Checkpoint: 004B76
- to stream Ncbi, to step Merge: 004743
- to stream Ncbi, to step Curation: 004743
- to stream Ncbi, to step Checkpoint: 004743
- to stream Main, to step Merge: 008F42
- to stream Main, to step Curation: 005D03
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Visual and auditory evoked potentials in early onset parkinson's disease and their relationship to cerebrospinal fluid monoamine metabolites</title><author><name sortKey="Muthane" sort="Muthane" uniqKey="Muthane" last="Muthane">Muthane</name></author><author><name sortKey="Satishchandra, P" sort="Satishchandra, P" uniqKey="Satishchandra P" first="P." last="Satishchandra">P. Satishchandra</name></author><author><name sortKey="Subhash, M N" sort="Subhash, M N" uniqKey="Subhash M" first="M. N." last="Subhash">M. N. Subhash</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:56E020AA28F1DDBFD6E8EABF4972AC68B84E71C7</idno><date when="1993" year="1993">1993</date><idno type="doi">10.1002/mds.870080316</idno><idno type="url">https://api.istex.fr/document/56E020AA28F1DDBFD6E8EABF4972AC68B84E71C7/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001992</idno><idno type="wicri:Area/Istex/Curation">001992</idno><idno type="wicri:Area/Istex/Checkpoint">003F70</idno><idno type="wicri:doubleKey">0885-3185:1993:Muthane:visual:and:auditory</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:7688076</idno><idno type="wicri:Area/PubMed/Corpus">004C26</idno><idno type="wicri:Area/PubMed/Curation">004C26</idno><idno type="wicri:Area/PubMed/Checkpoint">004B76</idno><idno type="wicri:Area/Ncbi/Merge">004743</idno><idno type="wicri:Area/Ncbi/Curation">004743</idno><idno type="wicri:Area/Ncbi/Checkpoint">004743</idno><idno type="wicri:doubleKey">0885-3185:1993:Muthane U:visual:and:auditory</idno><idno type="wicri:Area/Main/Merge">008F42</idno><idno type="wicri:Area/Main/Curation">005D03</idno><idno type="wicri:Area/Main/Exploration">005D03</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Visual and auditory evoked potentials in early onset parkinson's disease and their relationship to cerebrospinal fluid monoamine metabolites</title><author><name sortKey="Muthane" sort="Muthane" uniqKey="Muthane" last="Muthane">Muthane</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore</wicri:regionArea><wicri:noRegion>Bangalore</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, College of Physicians and Surgeons, Columbia‐Prebyterian Medical Center, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Satishchandra, P" sort="Satishchandra, P" uniqKey="Satishchandra P" first="P." last="Satishchandra">P. Satishchandra</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore</wicri:regionArea><wicri:noRegion>Bangalore</wicri:noRegion></affiliation></author><author><name sortKey="Subhash, M N" sort="Subhash, M N" uniqKey="Subhash M" first="M. N." last="Subhash">M. N. Subhash</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Neurochemistry, National Institute of Mental Health and Neurosciences, Bangalore</wicri:regionArea><wicri:noRegion>Bangalore</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1993">1993</date><biblScope unit="vol">8</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="344">344</biblScope><biblScope unit="page" to="348">348</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">56E020AA28F1DDBFD6E8EABF4972AC68B84E71C7</idno><idno type="DOI">10.1002/mds.870080316</idno><idno type="ArticleID">MDS870080316</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acoustic Stimulation</term><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Early onset Parkinson's disease</term><term>Evoked Potentials, Auditory, Brain Stem</term><term>Evoked Potentials, Visual</term><term>Evoked potentials</term><term>Female</term><term>Homovanillic Acid (cerebrospinal fluid)</term><term>Homovanillic Acid (metabolism)</term><term>Humans</term><term>Hydroxyindoleacetic Acid (cerebrospinal fluid)</term><term>Hydroxyindoleacetic Acid (metabolism)</term><term>Juvenile parkinsonism</term><term>Male</term><term>Middle Aged</term><term>Monoamine metabolites</term><term>Parkinson Disease (cerebrospinal fluid)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (metabolism)</term><term>Parkinson's disease</term><term>Photic Stimulation</term><term>Young onset Parkinson's disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Homovanillic Acid</term><term>Hydroxyindoleacetic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Homovanillic Acid</term><term>Hydroxyindoleacetic Acid</term></keywords><keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acoustic Stimulation</term><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Evoked Potentials, Auditory, Brain Stem</term><term>Evoked Potentials, Visual</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Photic Stimulation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied visual (VEP) and brainstem auditory (BAEP) evoked potential changes in 23 patients with early onset Parkinson's disease (EOPD) to establish the nature of the changes as well as their relationship to dopaminergic (DA) and serotonergic (5‐HT) disturbances, as determined by cerebrospinal fuid levels of homovanillic acid (HVA) and 5‐hydroxyindoleacetic acid (5‐HIAA). We also compared these parameters between the young onset (YOPD) and juvenile Parkinsonism (JP), the two subgroups of EOPD, to look for any possible differences between the two. In EOPD, the mean P100 latency of the VEP was significantly prolonged compared to controls (p < 0.001). However, within EOPD the evoked potential parameters were not significantly different between YOPD and the JP subgroups. P100 latency was abnormal in six patients (YOPD: 5, JP:1) (26%). Six patients (YOPD: 3, JP:3) (26%) had abnormal BAEP. A significant negative correlation (r: −0.89, p <1%) was observed between the P100 latency and CSF HVA levels. No correlation was observed between the BAEP interpeak latencies and either CSF HVA or 5‐HIAA levels. This study suggests that VEP and BAEP abnormalities do occur in EOPD (in both YOPD and JP), and that the prolongation of P100 latency is secondary to DA deficiency as in PD. The cause of BAEP abnormalities in EOPD. There was no correlation between the VEP or BAEP changes to either the age at onset or duration of EOPD.</div></front></TEI><affiliations><list><country><li>Inde</li><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="Inde"><noRegion><name sortKey="Muthane" sort="Muthane" uniqKey="Muthane" last="Muthane">Muthane</name></noRegion><name sortKey="Satishchandra, P" sort="Satishchandra, P" uniqKey="Satishchandra P" first="P." last="Satishchandra">P. Satishchandra</name><name sortKey="Subhash, M N" sort="Subhash, M N" uniqKey="Subhash M" first="M. N." last="Subhash">M. N. Subhash</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Muthane" sort="Muthane" uniqKey="Muthane" last="Muthane">Muthane</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005D03 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 005D03 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:56E020AA28F1DDBFD6E8EABF4972AC68B84E71C7
|texte= Visual and auditory evoked potentials in early onset parkinson's disease and their relationship to cerebrospinal fluid monoamine metabolites
}}
| This area was generated with Dilib version V0.6.23. |  |