Orobuccal dyskinesia associated with trihexyphenidyl therapy in a patient with parkinson's disease
Identifieur interne : 005D57 ( Main/Exploration ); précédent : 005D56; suivant : 005D58Orobuccal dyskinesia associated with trihexyphenidyl therapy in a patient with parkinson's disease
Auteurs : Robert A. Hauser [États-Unis] ; Olanow [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 1993.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Acetylcholine, Antagonist, Anticholinergic, Antiparkinson agent, Buccofacial dyskinesia, Case study, Dyskinesia, Dyskinesia, Drug-Induced, Human, Humans, Male, Middle Aged, Parasympatholytics (adverse effects), Parasympatholytics (therapeutic use), Parkinson Disease (drug therapy), Parkinson disease, Parkinson's disease, Toxicity, Trihexyphenidyl, Trihexyphenidyl (adverse effects), Trihexyphenidyl (therapeutic use), Videotape Recording.
- MESH :
- chemical , adverse effects : Parasympatholytics, Trihexyphenidyl.
- chemical , therapeutic use : Parasympatholytics, Trihexyphenidyl.
- drug therapy : Parkinson Disease.
- Dyskinesia, Drug-Induced, Humans, Male, Middle Aged, Videotape Recording.
Abstract
Dyskinesia is a common adverse effect complicating chronic dopaminergic therapy for Parkinson's disease. Movements are frequently choreic in nature and have been ascribed to overstimulation of “supersensitive” striatal postsynaptic dopamine receptors. Anticholinergic medications, despite some clinical efficacy in Parkinson's disease, have rarely been reported to cause dyskinesia. We report a patient with Parkinson's disease who developed orobuccal dyskinesia while being treated with trihexyphenidyl (Artane). Dyskinesia was observed following the introduction of trihexyphenidyl, resolved with its discontinuation, and reappeared with its reinstitution. Carbidopa‐levodopa (Sinemet) alone did not cause dyskinesia but augmented dyskinesia associated with trihexyphenidyl.
Url:
DOI: 10.1002/mds.870080417
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1993">1993</date><biblScope unit="vol">8</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="512">512</biblScope><biblScope unit="page" to="514">514</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">E358AD7CB53375B5223EB082DFBF3E90AB24D25F</idno><idno type="DOI">10.1002/mds.870080417</idno><idno type="ArticleID">MDS870080417</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetylcholine</term><term>Antagonist</term><term>Anticholinergic</term><term>Antiparkinson agent</term><term>Buccofacial dyskinesia</term><term>Case study</term><term>Dyskinesia</term><term>Dyskinesia, Drug-Induced</term><term>Human</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parasympatholytics (adverse effects)</term><term>Parasympatholytics (therapeutic use)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Toxicity</term><term>Trihexyphenidyl</term><term>Trihexyphenidyl (adverse effects)</term><term>Trihexyphenidyl (therapeutic use)</term><term>Videotape Recording</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Parasympatholytics</term><term>Trihexyphenidyl</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Parasympatholytics</term><term>Trihexyphenidyl</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Videotape Recording</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Acétylcholine</term><term>Antagoniste</term><term>Antiparkinsonien</term><term>Dyskinésie buccofaciale</term><term>Etude cas</term><term>Homme</term><term>Parkinson maladie</term><term>Toxicité</term><term>Trihexyphénidyle</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dyskinesia is a common adverse effect complicating chronic dopaminergic therapy for Parkinson's disease. Movements are frequently choreic in nature and have been ascribed to overstimulation of “supersensitive” striatal postsynaptic dopamine receptors. Anticholinergic medications, despite some clinical efficacy in Parkinson's disease, have rarely been reported to cause dyskinesia. We report a patient with Parkinson's disease who developed orobuccal dyskinesia while being treated with trihexyphenidyl (Artane). Dyskinesia was observed following the introduction of trihexyphenidyl, resolved with its discontinuation, and reappeared with its reinstitution. Carbidopa‐levodopa (Sinemet) alone did not cause dyskinesia but augmented dyskinesia associated with trihexyphenidyl.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li></region><settlement><li>Tampa</li></settlement><orgName><li>Université de Floride du Sud</li></orgName></list><tree><country name="États-Unis"><region name="Floride"><name sortKey="Hauser, Robert A" sort="Hauser, Robert A" uniqKey="Hauser R" first="Robert A." last="Hauser">Robert A. Hauser</name></region><name sortKey="Olanow" sort="Olanow" uniqKey="Olanow" last="Olanow">Olanow</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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