The abnormality of N30 somatosensory evoked potential in idiopathic Parkinson's disease is unrelated to disease stage or clinical scores and insensitive to dopamine manipulations
Identifieur interne : 005816 ( Main/Exploration ); précédent : 005815; suivant : 005817The abnormality of N30 somatosensory evoked potential in idiopathic Parkinson's disease is unrelated to disease stage or clinical scores and insensitive to dopamine manipulations
Auteurs : Onofrj ; T. Fulgente ; G. Malatesta ; F. Ferracci ; A. Thomas ; L. Curatola ; F. Bollettini ; M. Ragno [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 1995-01.
English descriptors
- KwdEn :
- Aged, Arm (physiopathology), Bromocriptine, Disease Progression, Dopamine (physiology), Dystonia (physiopathology), Evoke potential, Evoked Potentials, Somatosensory, Humans, L‐Dopa, Middle Aged, Movement Disorders (physiopathology), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson's disease, Parkinsonism, Tremor (physiopathology).
- MESH :
- chemical , physiology : Dopamine.
- diagnosis : Parkinson Disease.
- physiopathology : Arm, Dystonia, Movement Disorders, Parkinson Disease, Tremor.
- Aged, Disease Progression, Evoked Potentials, Somatosensory, Humans, Middle Aged.
Abstract
We recorded short latency somatosensory evoked potentials (SEPs) to median nerve stimuli in 40 patients affected by idiopathic Parkinson's disease (PD) classified from I to IV on the Hoehn and Yahr disability scale. SEPs were recorded before and after chronic administration of L‐Dopa and bromocriptine, before and after acute administration of L‐Dopa. Fourteen patients experiencing wearing off and dystonic‐dyskinetic disturbances were recorded during the occurrence of these oscillations of their clinical status. Absent or reduced N30 components were found in 32.5% of patients. SEPs were not modified by acute or chronic administration of L‐Dopa or bromocriptine or during off and dystonic or dyskinetic conditions. Multiple correlations of N30 with scores of the Unified Parkinson's Disease Rating Scale showed that N30 abnormality did not classify patient with prominent clinical features, nor did it predict the outcome of treatment.
Url:
DOI: 10.1002/mds.870100112
Affiliations:
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Benedetto del Tronto</wicri:noCountry></affiliation></author><author><name sortKey="Bollettini, F" sort="Bollettini, F" uniqKey="Bollettini F" first="F." last="Bollettini">F. Bollettini</name><affiliation><wicri:noCountry code="subField">Hospital of S. Benedetto del Tronto</wicri:noCountry></affiliation></author><author><name sortKey="Ragno, M" sort="Ragno, M" uniqKey="Ragno M" first="M." last="Ragno">M. Ragno</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Hospital of Ascoli Piceno</wicri:regionArea><wicri:noRegion>Hospital of Ascoli Piceno</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1995-01">1995-01</date><biblScope unit="vol">10</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="71">71</biblScope><biblScope unit="page" to="80">80</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">6FE0F9FD828734F48B5E7071F6FCDE445AA995D7</idno><idno type="DOI">10.1002/mds.870100112</idno><idno type="ArticleID">MDS870100112</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Arm (physiopathology)</term><term>Bromocriptine</term><term>Disease Progression</term><term>Dopamine (physiology)</term><term>Dystonia (physiopathology)</term><term>Evoke potential</term><term>Evoked Potentials, Somatosensory</term><term>Humans</term><term>L‐Dopa</term><term>Middle Aged</term><term>Movement Disorders (physiopathology)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson's disease</term><term>Parkinsonism</term><term>Tremor (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Arm</term><term>Dystonia</term><term>Movement Disorders</term><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Disease Progression</term><term>Evoked Potentials, Somatosensory</term><term>Humans</term><term>Middle Aged</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We recorded short latency somatosensory evoked potentials (SEPs) to median nerve stimuli in 40 patients affected by idiopathic Parkinson's disease (PD) classified from I to IV on the Hoehn and Yahr disability scale. SEPs were recorded before and after chronic administration of L‐Dopa and bromocriptine, before and after acute administration of L‐Dopa. Fourteen patients experiencing wearing off and dystonic‐dyskinetic disturbances were recorded during the occurrence of these oscillations of their clinical status. Absent or reduced N30 components were found in 32.5% of patients. SEPs were not modified by acute or chronic administration of L‐Dopa or bromocriptine or during off and dystonic or dyskinetic conditions. Multiple correlations of N30 with scores of the Unified Parkinson's Disease Rating Scale showed that N30 abnormality did not classify patient with prominent clinical features, nor did it predict the outcome of treatment.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Bollettini, F" sort="Bollettini, F" uniqKey="Bollettini F" first="F." last="Bollettini">F. Bollettini</name><name sortKey="Curatola, L" sort="Curatola, L" uniqKey="Curatola L" first="L." last="Curatola">L. Curatola</name><name sortKey="Ferracci, F" sort="Ferracci, F" uniqKey="Ferracci F" first="F." last="Ferracci">F. Ferracci</name><name sortKey="Fulgente, T" sort="Fulgente, T" uniqKey="Fulgente T" first="T." last="Fulgente">T. Fulgente</name><name sortKey="Malatesta, G" sort="Malatesta, G" uniqKey="Malatesta G" first="G." last="Malatesta">G. Malatesta</name><name sortKey="Onofrj" sort="Onofrj" uniqKey="Onofrj" last="Onofrj">Onofrj</name><name sortKey="Thomas, A" sort="Thomas, A" uniqKey="Thomas A" first="A." last="Thomas">A. Thomas</name></noCountry><country name="Italie"><noRegion><name sortKey="Ragno, M" sort="Ragno, M" uniqKey="Ragno M" first="M." last="Ragno">M. Ragno</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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