Action tremor and weakness in Parkinson's disease: A study of the elbow extensors
Identifieur interne : 005086 ( Main/Exploration ); précédent : 005085; suivant : 005087Action tremor and weakness in Parkinson's disease: A study of the elbow extensors
Auteurs : Brown [Royaume-Uni] ; Daniel M. Corcos [Royaume-Uni, États-Unis] ; John C. Rothwell [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 1998-01.
English descriptors
- KwdEn :
- Action tremor, Aged, Antiparkinson Agents (pharmacology), Case-Control Studies, Elbow Joint (drug effects), Elbow Joint (physiology), Elbow extensors, Electromyography, Female, Humans, Intervention Studies, Longitudinal Studies, Male, Middle Aged, Muscle Contraction (drug effects), Muscle Contraction (physiology), Muscle Weakness (drug therapy), Muscle Weakness (physiopathology), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson's disease, Torque, Tremor (drug therapy), Tremor (physiopathology), Weakness.
- MESH :
- chemical , pharmacology : Antiparkinson Agents.
- drug effects : Elbow Joint, Muscle Contraction.
- drug therapy : Muscle Weakness, Parkinson Disease, Tremor.
- physiology : Elbow Joint, Muscle Contraction.
- physiopathology : Muscle Weakness, Parkinson Disease, Tremor.
- Aged, Case-Control Studies, Electromyography, Female, Humans, Intervention Studies, Longitudinal Studies, Male, Middle Aged, Torque.
Abstract
We have previously shown that action tremor persists during maximal wrist extension in patients with Parkinson's disease, and that this contributes to weakness at this joint by preventing the fully fused contraction of the forearm extensor muscles. Antiparkinsonian medication reduces the action tremor in torque and electromyographic (EMG) records, thereby improving strengh at the wrist. In the present experiments, peak torque and action tremor were recorded during maximal extension of the elbow in nine patients with Parkinson's disease while they were on and off antiparkinsonian medication, and in eight age‐ and sex‐matched healthy subjects. Peak torque and mean rectified EMG levels were reduced by 34% and 36%, respectively, during maximal elbow extension when patients off medication were compared to those in the treated state. Action tremor was visible in torque records and had a frequency of ∼ 10 Hz both in parkinsonian patients and in normal controls. Activity of a similar frequency was often detected in EMG records, especially in patients off therapy. The absolute amplitude of action tremor in torque (Atorque) and EMG (AEMG) records from the elbow was unaffected by therapy and was little different from that recorded in healthy controls. The relative action tremor in torque ([Atorque/peak torque] × 100) and EMG ([AEMG/mean rectified EMG] × 100) was reduced by treatment, but this was the result of the increase in peak torque and mean rectified EMG. Thus, in contrast to the results at the wrist, antiparkinsonian medication has little effect on the 10‐Hz action tremor at the elbow. Increased strength is produced by a different mechanism which allows recruitment of triceps motor units outside of this synchronizing influence.
Url:
DOI: 10.1002/mds.870130114
Affiliations:
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Le document en format XML
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<term>Elbow Joint (physiology)</term>
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<term>Muscle Contraction (physiology)</term>
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<front><div type="abstract" xml:lang="en">We have previously shown that action tremor persists during maximal wrist extension in patients with Parkinson's disease, and that this contributes to weakness at this joint by preventing the fully fused contraction of the forearm extensor muscles. Antiparkinsonian medication reduces the action tremor in torque and electromyographic (EMG) records, thereby improving strengh at the wrist. In the present experiments, peak torque and action tremor were recorded during maximal extension of the elbow in nine patients with Parkinson's disease while they were on and off antiparkinsonian medication, and in eight age‐ and sex‐matched healthy subjects. Peak torque and mean rectified EMG levels were reduced by 34% and 36%, respectively, during maximal elbow extension when patients off medication were compared to those in the treated state. Action tremor was visible in torque records and had a frequency of ∼ 10 Hz both in parkinsonian patients and in normal controls. Activity of a similar frequency was often detected in EMG records, especially in patients off therapy. The absolute amplitude of action tremor in torque (Atorque) and EMG (AEMG) records from the elbow was unaffected by therapy and was little different from that recorded in healthy controls. The relative action tremor in torque ([Atorque/peak torque] × 100) and EMG ([AEMG/mean rectified EMG] × 100) was reduced by treatment, but this was the result of the increase in peak torque and mean rectified EMG. Thus, in contrast to the results at the wrist, antiparkinsonian medication has little effect on the 10‐Hz action tremor at the elbow. Increased strength is produced by a different mechanism which allows recruitment of triceps motor units outside of this synchronizing influence.</div>
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