Neural Transplantation in Parkinson's Disease and Its Effects on Rest Tremor: A Review of the Literature
Identifieur interne : 004F48 ( Main/Exploration ); précédent : 004F47; suivant : 004F49Neural Transplantation in Parkinson's Disease and Its Effects on Rest Tremor: A Review of the Literature
Auteurs : O. Pogarell [Allemagne] ; W. H. Oertel [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 1998.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Bibliographic review, Clinical trial, Corpus Striatum (embryology), Corpus Striatum (transplantation), Corpus striatum, Dopaminergic neuron, Fetal Tissue Transplantation (methods), Fetal striatal transplantation, Fetus, Graft, Human, Humans, Indication, Midbrain, Parkinson Disease (complications), Parkinson Disease (surgery), Parkinson disease, Parkinson's disease, Prognosis, Rest tremor, Resting tremor, Treatment, Tremor (etiology).
- MESH :
- complications : Parkinson Disease.
- embryology : Corpus Striatum.
- etiology : Tremor.
- methods : Fetal Tissue Transplantation.
- surgery : Parkinson Disease.
- transplantation : Corpus Striatum.
- Humans.
Abstract
The transplantation of fetal mesencephalic dopaminergic tissue into the striatum of parkinsonian (PD) patients is an experimental therapeutic approach. The target population for this treatment are advanced, predominantly akinetic‐rigid patients with therapy‐associated complications, and not tremordominant PD patients. Based on a review of selected published data, no specific beneficial effect of fetal mesencephalic transplantation in PD patients was reported on the cardinal symptom rest tremor. On the one hand, this might be the result of a lack of efficacy of this treatment with respect to tremor; on the other hand, PD patients with predominant tremor may have a better prognosis with respect to motor function and therefore might not reach the advanced akinetic‐rigid stage, which makes them eligible for neural transplantation. Rest‐tremor dominant PD patients have not undergone fetal cell grafting; therefore its effect on rest tremor is unknown.
Url:
DOI: 10.1002/mds.870131317
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1998">1998</date><biblScope unit="vol">13</biblScope><biblScope unit="issue">S3</biblScope><biblScope unit="page" from="101">101</biblScope><biblScope unit="page" to="102">102</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">4C018DEC8915667635E62536DE93F6ABE99E4F40</idno><idno type="DOI">10.1002/mds.870131317</idno><idno type="ArticleID">MDS870131317</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bibliographic review</term><term>Clinical trial</term><term>Corpus Striatum (embryology)</term><term>Corpus Striatum (transplantation)</term><term>Corpus striatum</term><term>Dopaminergic neuron</term><term>Fetal Tissue Transplantation (methods)</term><term>Fetal striatal transplantation</term><term>Fetus</term><term>Graft</term><term>Human</term><term>Humans</term><term>Indication</term><term>Midbrain</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (surgery)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Prognosis</term><term>Rest tremor</term><term>Resting tremor</term><term>Treatment</term><term>Tremor (etiology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Corpus Striatum</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Fetal Tissue Transplantation</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Corpus Striatum</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Corps strié</term><term>Essai clinique</term><term>Foetus</term><term>Greffe</term><term>Homme</term><term>Indication</term><term>Mésencéphale</term><term>Neurone dopaminergique</term><term>Parkinson maladie</term><term>Pronostic</term><term>Revue bibliographique</term><term>Traitement</term><term>Tremblement repos</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The transplantation of fetal mesencephalic dopaminergic tissue into the striatum of parkinsonian (PD) patients is an experimental therapeutic approach. The target population for this treatment are advanced, predominantly akinetic‐rigid patients with therapy‐associated complications, and not tremordominant PD patients. Based on a review of selected published data, no specific beneficial effect of fetal mesencephalic transplantation in PD patients was reported on the cardinal symptom rest tremor. On the one hand, this might be the result of a lack of efficacy of this treatment with respect to tremor; on the other hand, PD patients with predominant tremor may have a better prognosis with respect to motor function and therefore might not reach the advanced akinetic‐rigid stage, which makes them eligible for neural transplantation. Rest‐tremor dominant PD patients have not undergone fetal cell grafting; therefore its effect on rest tremor is unknown.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Giessen</li><li>Hesse (Land)</li></region><settlement><li>Marbourg</li></settlement></list><tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Pogarell, O" sort="Pogarell, O" uniqKey="Pogarell O" first="O." last="Pogarell">O. Pogarell</name></region><name sortKey="Oertel, W H" sort="Oertel, W H" uniqKey="Oertel W" first="W. H." last="Oertel">W. H. Oertel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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