Models of Parkinson's disease
Identifieur interne : 004038 ( Main/Exploration ); précédent : 004037; suivant : 004039Models of Parkinson's disease
Auteurs : Michael Orth [Royaume-Uni] ; Sarah J. Tabrizi [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-07.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animal, Animals, Apoptosis (drug effects), Apoptosis (genetics), Cell culture, Cells, Cultured (drug effects), DNA Mutational Analysis, Disease Models, Animal, Dopamine Agents (toxicity), Human, Humans, Mice, Mice, Knockout, Mice, Transgenic, Models, Models, Genetic, Nerve Tissue Proteins (genetics), Oxidopamine (toxicity), Parkinson disease, Parkinson's disease, Parkinsonian Disorders (chemically induced), Parkinsonian Disorders (genetics), Risk Factors, Rotenone (toxicity), Substantia Nigra (drug effects), Synucleins, cell culture, disease models, transgenic mice.
- MESH :
- chemical , genetics : Nerve Tissue Proteins.
- chemical , toxicity : Dopamine Agents, Oxidopamine, Rotenone.
- chemical : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Synucleins.
- chemically induced : Parkinsonian Disorders.
- drug effects : Apoptosis, Cells, Cultured, Substantia Nigra.
- genetics : Apoptosis, Parkinsonian Disorders.
- Animals, DNA Mutational Analysis, Disease Models, Animal, Humans, Mice, Mice, Knockout, Mice, Transgenic, Models, Genetic, Risk Factors.
Abstract
Parkinson's disease (PD) is a heterogenous disease likely to be caused by more than one specific aetiological factor. In rare familial cases of PD with similar clinical features to the idiopathic form of the disease, the underlying genetic cause has been identified. These PD‐associated genes have been manipulated to create animal and cell culture models of the disease that have helped to further our understanding of the pathogenesis of PD, particularly concerning causes of the selective loss of dopaminergic neurons at the molecular level. In addition, these models will aid the future development of rational therapeutic strategies. This study briefly reviews toxin‐induced models and the genetics of PD. It focuses on recently developed animal models of PD, as well as in vitro approaches to model the disease. © 2003 Movement Disorder Society
Url:
DOI: 10.1002/mds.10447
Affiliations:
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Le document en format XML
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<term>Apoptosis (drug effects)</term>
<term>Apoptosis (genetics)</term>
<term>Cell culture</term>
<term>Cells, Cultured (drug effects)</term>
<term>DNA Mutational Analysis</term>
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<term>Parkinson disease</term>
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<term>Parkinsonian Disorders (genetics)</term>
<term>Risk Factors</term>
<term>Rotenone (toxicity)</term>
<term>Substantia Nigra (drug effects)</term>
<term>Synucleins</term>
<term>cell culture</term>
<term>disease models</term>
<term>transgenic mice</term>
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<term>Parkinsonian Disorders</term>
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<term>DNA Mutational Analysis</term>
<term>Disease Models, Animal</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Knockout</term>
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<term>Risk Factors</term>
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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a heterogenous disease likely to be caused by more than one specific aetiological factor. In rare familial cases of PD with similar clinical features to the idiopathic form of the disease, the underlying genetic cause has been identified. These PD‐associated genes have been manipulated to create animal and cell culture models of the disease that have helped to further our understanding of the pathogenesis of PD, particularly concerning causes of the selective loss of dopaminergic neurons at the molecular level. In addition, these models will aid the future development of rational therapeutic strategies. This study briefly reviews toxin‐induced models and the genetics of PD. It focuses on recently developed animal models of PD, as well as in vitro approaches to model the disease. © 2003 Movement Disorder Society</div>
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