MovDisordV3, Main, Exploration, bibRecord, 003F07

Treatment of advanced Parkinson's disease by subthalamotomy: One‐year results

Identifieur interne : 003F07 ( Main/Exploration ); précédent : 003F06; suivant : 003F08

Treatment of advanced Parkinson's disease by subthalamotomy: One‐year results

Auteurs : Philip C. Su [République populaire de Chine] ; Ham-Min Tseng [République populaire de Chine] ; Hon-Man Liu [République populaire de Chine] ; Ruoh-Fang Yen [République populaire de Chine] ; Horng-Huei Liou [République populaire de Chine]

Source :

Movement Disorders [ 0885-3185 ] ; 2003-05.

RBID : ISTEX:B54D1CD39D66C367B007F609C001962141869B62

Descripteurs français

Pascal (Inist)
- Chirurgie, Etude longitudinale, Homme, Noyau sousthalamique, Parkinson maladie, Traitement, Unilatéral.
Wicri :
- topic : Chirurgie, Homme.

English descriptors

KwdEn :
- Adult, Aged, Antiparkinson Agents (therapeutic use), Dyskinesias (diagnosis), Dyskinesias (epidemiology), Electrocoagulation, Female, Follow up study, Follow-Up Studies, Human, Humans, Hypokinesia (diagnosis), Levodopa (therapeutic use), Magnetic Resonance Imaging, Male, Microelectrodes, Middle Aged, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson Disease (surgery), Parkinson disease, Parkinson's disease, Postoperative Complications, Posture, Questionnaires, Severity of Illness Index, Subthalamic Nucleus (pathology), Subthalamic Nucleus (surgery), Subthalamic nucleus, Surgery, Time, Treatment, Unilateral, hemiballism, microelectrode, subthalamic nucleus, subthalamotomy, surgical ablative therapy.
MESH :
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- diagnosis : Dyskinesias, Hypokinesia.
- drug therapy : Parkinson Disease.
- epidemiology : Dyskinesias.
- pathology : Subthalamic Nucleus.
- physiopathology : Parkinson Disease.
- surgery : Parkinson Disease, Subthalamic Nucleus.
- Adult, Aged, Electrocoagulation, Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Male, Microelectrodes, Middle Aged, Postoperative Complications, Posture, Questionnaires, Severity of Illness Index, Time.

Abstract

We studied effects on parkinsonian features at 6 and 12 months in 12 patients who underwent unilateral ablation of subthalamic nucleus (STN). Microelectrode mapping was used, and a lesion was created in the STN using thermal coagulation and confirmed with magnetic resonance imaging. At 6 months postoperatively, improvements were seen in several areas: 1) Unified Parkinson's Disease Rating Scales II and III (UPDRS II and III) scores, 30% in off period, 38% in on period; 2) Schwab and England Scale (S&E) score, 21%; and 3) on dyskinesia, 85%. Contralateral rigidity, bradykinesia, UPDRS II and III scores, and S&E scores remained improved at 12 months. Daily dosage of levodopa requirement was reduced by 42%. Axial motor features, gait, postural stability, off period tremor, and motor fluctuation improved at 6 and 12 months but showed a decline in benefits at 18 months. Complications include 3 cases of hemiballism, of whom 2 patients recovered spontaneously but 1 died from aspiration pneumonia. One patient had asymptomatic hematoma, and 2 suffered transient postural asymmetries. We conclude that unilateral subthalamotomy results in moderate improvement in all aspects of parkinsonian features, allows reduction in the dose of levodopa required, and ameliorates drug‐induced complications throughout 12‐month assessments. © 2003 Movement Disorder Society

Url:

https://api.istex.fr/document/B54D1CD39D66C367B007F609C001962141869B62/fulltext/pdf

DOI: 10.1002/mds.10393

Affiliations:

République populaire de Chine

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<term>Dyskinesias (epidemiology)</term>
<term>Electrocoagulation</term>
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<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (surgery)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Postoperative Complications</term>
<term>Posture</term>
<term>Questionnaires</term>
<term>Severity of Illness Index</term>
<term>Subthalamic Nucleus (pathology)</term>
<term>Subthalamic Nucleus (surgery)</term>
<term>Subthalamic nucleus</term>
<term>Surgery</term>
<term>Time</term>
<term>Treatment</term>
<term>Unilateral</term>
<term>hemiballism</term>
<term>microelectrode</term>
<term>subthalamic nucleus</term>
<term>subthalamotomy</term>
<term>surgical ablative therapy</term>
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<term>Subthalamic Nucleus</term>
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<term>Microelectrodes</term>
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<term>Questionnaires</term>
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<front><div type="abstract" xml:lang="en">We studied effects on parkinsonian features at 6 and 12 months in 12 patients who underwent unilateral ablation of subthalamic nucleus (STN). Microelectrode mapping was used, and a lesion was created in the STN using thermal coagulation and confirmed with magnetic resonance imaging. At 6 months postoperatively, improvements were seen in several areas: 1) Unified Parkinson's Disease Rating Scales II and III (UPDRS II and III) scores, 30% in off period, 38% in on period; 2) Schwab and England Scale (S&E) score, 21%; and 3) on dyskinesia, 85%. Contralateral rigidity, bradykinesia, UPDRS II and III scores, and S&E scores remained improved at 12 months. Daily dosage of levodopa requirement was reduced by 42%. Axial motor features, gait, postural stability, off period tremor, and motor fluctuation improved at 6 and 12 months but showed a decline in benefits at 18 months. Complications include 3 cases of hemiballism, of whom 2 patients recovered spontaneously but 1 died from aspiration pneumonia. One patient had asymptomatic hematoma, and 2 suffered transient postural asymmetries. We conclude that unilateral subthalamotomy results in moderate improvement in all aspects of parkinsonian features, allows reduction in the dose of levodopa required, and ameliorates drug‐induced complications throughout 12‐month assessments. © 2003 Movement Disorder Society</div>
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Movement Disorders (revue)

Treatment of advanced Parkinson's disease by subthalamotomy: One‐year results

Treatment of advanced Parkinson's disease by subthalamotomy: One‐year results

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.