Long‐term botulinum toxin efficacy, safety, and immunogenicity
Identifieur interne : 003861 ( Main/Exploration ); précédent : 003860; suivant : 003862Long‐term botulinum toxin efficacy, safety, and immunogenicity
Auteurs : Nicte I. Mejia [États-Unis] ; Kevin Dat Vuong [États-Unis] ; Joseph Jankovic [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-05.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Antibodies (immunology), Blepharoptosis (drug therapy), Blepharoptosis (immunology), Blepharoptosis (physiopathology), Bontoxilysin, Botulinum Toxins, Type A (administration & dosage), Botulinum Toxins, Type A (adverse effects), Botulinum Toxins, Type A (therapeutic use), Complication, Deglutition Disorders (drug therapy), Deglutition Disorders (immunology), Deglutition Disorders (physiopathology), Drug Administration Schedule, Dystonia, Dystonia (drug therapy), Dystonia (immunology), Dystonia (physiopathology), Female, Hemifacial Spasm (drug therapy), Hemifacial Spasm (immunology), Hemifacial Spasm (physiopathology), Humans, Immunogenicity, Injections, Long term, Male, Middle Aged, Muscle Weakness (drug therapy), Muscle Weakness (immunology), Muscle Weakness (physiopathology), Neck Muscles (physiopathology), Nervous system diseases, Neuromuscular Agents (administration & dosage), Neuromuscular Agents (adverse effects), Neuromuscular Agents (therapeutic use), Safety, Time Factors, botulinum toxin, complications, dystonia, efficacy, immunogenicity, long‐term.
- MESH :
- chemical , administration & dosage : Botulinum Toxins, Type A, Neuromuscular Agents.
- chemical , adverse effects : Botulinum Toxins, Type A, Neuromuscular Agents.
- chemical , immunology : Antibodies.
- drug therapy : Blepharoptosis, Deglutition Disorders, Dystonia, Hemifacial Spasm, Muscle Weakness.
- immunology : Blepharoptosis, Deglutition Disorders, Dystonia, Hemifacial Spasm, Muscle Weakness.
- physiopathology : Blepharoptosis, Deglutition Disorders, Dystonia, Hemifacial Spasm, Muscle Weakness, Neck Muscles.
- chemical , therapeutic use : Botulinum Toxins, Type A, Neuromuscular Agents.
- Aged, Drug Administration Schedule, Female, Humans, Injections, Male, Middle Aged, Time Factors.
Abstract
To determine the long‐term efficacy of botulinum toxin (BTX) treatments, we analyzed longitudinal follow‐up data on 45 patients (32 women; mean age, 68.8 years) currently followed in the Baylor College of Medicine Movement Disorders Clinic, who have received BTX treatments continuously for at least 12 years (mean 15.8 ± 1.5 years). Their mean response rating after the last injection, based one a previously described scale 0‐to‐4 scale (0 = no effect; 4 = marked improvement) was 3.7 ± 0.6 and the mean total duration of response was 15.4 ± 3.4 weeks. Although the latency and total duration of the response to treatment have not changed over time, the peak duration of response (P < 0.005) and dose per visit (P < 0.0001) have increased since the initial visit. Furthermore, global rating (P < 0.02) and peak effect (P < 0.05) have improved. In total, 20 adverse events occurred in 16 of 45 (35.6%) patients after their initial visit and 11 adverse events in 10 of 45 (22.2%) patients at their most recent injection visit. Antibody (Ab) testing was carried out in 22 patients due to nonresponsiveness; blocking Abs were confirmed by the mouse protection assay in 4 of 22 (18%) patients. Of the Ab‐negative patients, 16 resumed responsiveness after dose adjustments and2 persisted as nonrespondents. Except for 1 patient, the 4 Ab‐positive and the 2 clinical nonresponders are being treated with BTX‐B. This longest reported follow‐up of BTX injections confirms the long‐term efficacy and safety of this treatment. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20376
Affiliations:
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Le document en format XML
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<term>Blepharoptosis (immunology)</term>
<term>Blepharoptosis (physiopathology)</term>
<term>Bontoxilysin</term>
<term>Botulinum Toxins, Type A (administration & dosage)</term>
<term>Botulinum Toxins, Type A (adverse effects)</term>
<term>Botulinum Toxins, Type A (therapeutic use)</term>
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<term>Deglutition Disorders (drug therapy)</term>
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<term>Hemifacial Spasm (immunology)</term>
<term>Hemifacial Spasm (physiopathology)</term>
<term>Humans</term>
<term>Immunogenicity</term>
<term>Injections</term>
<term>Long term</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Muscle Weakness (drug therapy)</term>
<term>Muscle Weakness (immunology)</term>
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<term>Neck Muscles (physiopathology)</term>
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<term>Neuromuscular Agents (administration & dosage)</term>
<term>Neuromuscular Agents (adverse effects)</term>
<term>Neuromuscular Agents (therapeutic use)</term>
<term>Safety</term>
<term>Time Factors</term>
<term>botulinum toxin</term>
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<term>dystonia</term>
<term>efficacy</term>
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<front><div type="abstract" xml:lang="en">To determine the long‐term efficacy of botulinum toxin (BTX) treatments, we analyzed longitudinal follow‐up data on 45 patients (32 women; mean age, 68.8 years) currently followed in the Baylor College of Medicine Movement Disorders Clinic, who have received BTX treatments continuously for at least 12 years (mean 15.8 ± 1.5 years). Their mean response rating after the last injection, based one a previously described scale 0‐to‐4 scale (0 = no effect; 4 = marked improvement) was 3.7 ± 0.6 and the mean total duration of response was 15.4 ± 3.4 weeks. Although the latency and total duration of the response to treatment have not changed over time, the peak duration of response (P < 0.005) and dose per visit (P < 0.0001) have increased since the initial visit. Furthermore, global rating (P < 0.02) and peak effect (P < 0.05) have improved. In total, 20 adverse events occurred in 16 of 45 (35.6%) patients after their initial visit and 11 adverse events in 10 of 45 (22.2%) patients at their most recent injection visit. Antibody (Ab) testing was carried out in 22 patients due to nonresponsiveness; blocking Abs were confirmed by the mouse protection assay in 4 of 22 (18%) patients. Of the Ab‐negative patients, 16 resumed responsiveness after dose adjustments and2 persisted as nonrespondents. Except for 1 patient, the 4 Ab‐positive and the 2 clinical nonresponders are being treated with BTX‐B. This longest reported follow‐up of BTX injections confirms the long‐term efficacy and safety of this treatment. © 2005 Movement Disorder Society</div>
</front>
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