MovDisordV3, Main, Exploration, bibRecord, 003072

The Prevalence of LRRK2 Gly2385Arg Variant in Chinese Han Population with Parkinson's Disease

Identifieur interne : 003072 ( Main/Exploration ); précédent : 003071; suivant : 003073

The Prevalence of LRRK2 Gly2385Arg Variant in Chinese Han Population with Parkinson's Disease

Auteurs : CAO LI [République populaire de Chine] ; ZHANG TING [République populaire de Chine] ; XIAO QIN [République populaire de Chine] ; WANG YING [République populaire de Chine] ; BAI LI [République populaire de Chine] ; LU GUO QIANG [République populaire de Chine] ; MA JIAN FANG [République populaire de Chine] ; ZHANG JING [République populaire de Chine] ; DING JIAN QING [République populaire de Chine] ; CHEN SHENG DI [République populaire de Chine]

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:08-0149316

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Prévalence, Chinois, Chine.

English descriptors

KwdEn :
- China, Chinese, Nervous system diseases, Parkinson disease, Prevalence.

Abstract

We conducted a case-control study to determine the prevalence of the LRRK2 Gly2385Arg variant in patients with Parkinson's disease in Han population in mainland China. Heterozygous LRRK2 Gly2385Arg variant was identified in 14 of 235 patients with Parkinson's disease (5.69%), but not in 214 unrelated healthy controls. Multivariate analysis indicated the frequency of Gly2385Arg variant in the female patients with early age at onset is higher than their male counterparts. The founder haplotype analysis showed the variant carriers shared the same founder. Clinically, the LRRK2 Gly2385Arg carriers presented with classical Parkinson's disease symptoms. Our study indicates that the LRRK2 Gly2385Arg variant is a potential ethnic-specific genetic risk factor of Parkinson's disease within Chinese Han ethnicity.

Affiliations:

République populaire de Chine

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 001347
to stream PascalFrancis, to step Curation: 001972
to stream PascalFrancis, to step Checkpoint: 001435
to stream Main, to step Merge: 004025
to stream Main, to step Curation: 003072

Le document en format XML

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<front><div type="abstract" xml:lang="en">We conducted a case-control study to determine the prevalence of the LRRK2 Gly2385Arg variant in patients with Parkinson's disease in Han population in mainland China. Heterozygous LRRK2 Gly2385Arg variant was identified in 14 of 235 patients with Parkinson's disease (5.69%), but not in 214 unrelated healthy controls. Multivariate analysis indicated the frequency of Gly2385Arg variant in the female patients with early age at onset is higher than their male counterparts. The founder haplotype analysis showed the variant carriers shared the same founder. Clinically, the LRRK2 Gly2385Arg carriers presented with classical Parkinson's disease symptoms. Our study indicates that the LRRK2 Gly2385Arg variant is a potential ethnic-specific genetic risk factor of Parkinson's disease within Chinese Han ethnicity.</div>
</front>
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<affiliations><list><country><li>République populaire de Chine</li>
</country>
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<tree><country name="République populaire de Chine"><noRegion><name sortKey="Cao Li" sort="Cao Li" uniqKey="Cao Li" last="Cao Li">CAO LI</name>
</noRegion>
<name sortKey="Bai Li" sort="Bai Li" uniqKey="Bai Li" last="Bai Li">BAI LI</name>
<name sortKey="Chen Sheng Di" sort="Chen Sheng Di" uniqKey="Chen Sheng Di" last="Chen Sheng Di">CHEN SHENG DI</name>
<name sortKey="Chen Sheng Di" sort="Chen Sheng Di" uniqKey="Chen Sheng Di" last="Chen Sheng Di">CHEN SHENG DI</name>
<name sortKey="Ding Jian Qing" sort="Ding Jian Qing" uniqKey="Ding Jian Qing" last="Ding Jian Qing">DING JIAN QING</name>
<name sortKey="Ding Jian Qing" sort="Ding Jian Qing" uniqKey="Ding Jian Qing" last="Ding Jian Qing">DING JIAN QING</name>
<name sortKey="Lu Guo Qiang" sort="Lu Guo Qiang" uniqKey="Lu Guo Qiang" last="Lu Guo Qiang">LU GUO QIANG</name>
<name sortKey="Ma Jian Fang" sort="Ma Jian Fang" uniqKey="Ma Jian Fang" last="Ma Jian Fang">MA JIAN FANG</name>
<name sortKey="Wang Ying" sort="Wang Ying" uniqKey="Wang Ying" last="Wang Ying">WANG YING</name>
<name sortKey="Xiao Qin" sort="Xiao Qin" uniqKey="Xiao Qin" last="Xiao Qin">XIAO QIN</name>
<name sortKey="Zhang Jing" sort="Zhang Jing" uniqKey="Zhang Jing" last="Zhang Jing">ZHANG JING</name>
<name sortKey="Zhang Ting" sort="Zhang Ting" uniqKey="Zhang Ting" last="Zhang Ting">ZHANG TING</name>
</country>
</tree>
</affiliations>
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	Movement Disorders (revue)
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Movement Disorders (revue)

The Prevalence of LRRK2 Gly2385Arg Variant in Chinese Han Population with Parkinson's Disease

The Prevalence of LRRK2 Gly2385Arg Variant in Chinese Han Population with Parkinson's Disease

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