Cortical grey matter alterations in idiopathic restless legs syndrome: An optimized voxel‐based morphometry study
Identifieur interne : 002F17 ( Main/Exploration ); précédent : 002F16; suivant : 002F18Cortical grey matter alterations in idiopathic restless legs syndrome: An optimized voxel‐based morphometry study
Auteurs : Alexander Unrath [Allemagne] ; Freimut D. Juengling [Suisse] ; Marion Schork [Allemagne] ; Jan Kassubek [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-09-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Case-Control Studies, Cerebral Cortex (pathology), Female, Functional Laterality, Grey matter, Humans, Idiopathic, Imaging, Three-Dimensional (methods), Magnetic Resonance Imaging (methods), Male, Middle Aged, Morphometry, Motor cortex, Nervous system diseases, Nuclear magnetic resonance imaging, Restless Legs Syndrome (pathology), Restless legs syndrome, Voxel, magnetic resonance imaging, motor cortex, restless legs syndrome, sensory cortex.
- MESH :
Abstract
An impairment of central somatosensory processing is assumed in restless legs syndrome (RLS). Although functional neuroimaging in RLS gave evidence to the presence of widespread functional changes in various brain areas, structural changes at the cortical level were not reported to be RLS‐associated to date. Here, an analysis of high‐resolution three‐dimensional magnetic resonance imaging (MRI) was performed in 63 patients with idiopathic RLS by use of optimized voxel‐based morphometry, in order to investigate if cortical areas might be altered in volume at group level according to the phenomenology of RLS. The comparison of the RLS patients versus controls yielded significant regional decreases of gray matter volume at corrected P < 0.05 in the bihemispheric primary somatosensory cortex, which additionally extended into left‐sided primary motor areas. All clusters correlated both with the severity of RLS symptoms and with disease duration. These results, for the first time, give in vivo evidence to structural neocortical gray matter alterations in RLS patients. The alterations in the sensorimotor cortices might add to the pathophysiological concepts of idiopathic RLS. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21608
Affiliations:
- Allemagne, Suisse
- Bade-Wurtemberg, Canton de Berne, District de Tübingen
- Berne, Ulm
- Université d'Ulm, Université de Berne
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-09-15">2007-09-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1751">1751</biblScope><biblScope unit="page" to="1756">1756</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C7FBA8D53B7D66C00C10F62569F428BCB1842B4D</idno><idno type="DOI">10.1002/mds.21608</idno><idno type="ArticleID">MDS21608</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Cerebral Cortex (pathology)</term><term>Female</term><term>Functional Laterality</term><term>Grey matter</term><term>Humans</term><term>Idiopathic</term><term>Imaging, Three-Dimensional (methods)</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Middle Aged</term><term>Morphometry</term><term>Motor cortex</term><term>Nervous system diseases</term><term>Nuclear magnetic resonance imaging</term><term>Restless Legs Syndrome (pathology)</term><term>Restless legs syndrome</term><term>Voxel</term><term>magnetic resonance imaging</term><term>motor cortex</term><term>restless legs syndrome</term><term>sensory cortex</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Imaging, Three-Dimensional</term><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cerebral Cortex</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cortex moteur</term><term>Idiopathique</term><term>Imagerie RMN</term><term>Impatience membre inférieur syndrome</term><term>Morphométrie</term><term>Substance grise</term><term>Système nerveux pathologie</term><term>Voxel</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An impairment of central somatosensory processing is assumed in restless legs syndrome (RLS). Although functional neuroimaging in RLS gave evidence to the presence of widespread functional changes in various brain areas, structural changes at the cortical level were not reported to be RLS‐associated to date. Here, an analysis of high‐resolution three‐dimensional magnetic resonance imaging (MRI) was performed in 63 patients with idiopathic RLS by use of optimized voxel‐based morphometry, in order to investigate if cortical areas might be altered in volume at group level according to the phenomenology of RLS. The comparison of the RLS patients versus controls yielded significant regional decreases of gray matter volume at corrected P < 0.05 in the bihemispheric primary somatosensory cortex, which additionally extended into left‐sided primary motor areas. All clusters correlated both with the severity of RLS symptoms and with disease duration. These results, for the first time, give in vivo evidence to structural neocortical gray matter alterations in RLS patients. The alterations in the sensorimotor cortices might add to the pathophysiological concepts of idiopathic RLS. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Suisse</li></country><region><li>Bade-Wurtemberg</li><li>Canton de Berne</li><li>District de Tübingen</li></region><settlement><li>Berne</li><li>Ulm</li></settlement><orgName><li>Université d'Ulm</li><li>Université de Berne</li></orgName></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Unrath, Alexander" sort="Unrath, Alexander" uniqKey="Unrath A" first="Alexander" last="Unrath">Alexander Unrath</name></region><name sortKey="Kassubek, Jan" sort="Kassubek, Jan" uniqKey="Kassubek J" first="Jan" last="Kassubek">Jan Kassubek</name><name sortKey="Schork, Marion" sort="Schork, Marion" uniqKey="Schork M" first="Marion" last="Schork">Marion Schork</name></country><country name="Suisse"><region name="Canton de Berne"><name sortKey="Juengling, Freimut D" sort="Juengling, Freimut D" uniqKey="Juengling F" first="Freimut D." last="Juengling">Freimut D. Juengling</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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