Methylphenidate improves fatigue scores in Parkinson disease: A randomized controlled trial
Identifieur interne : 002D46 ( Main/Exploration ); précédent : 002D45; suivant : 002D47Methylphenidate improves fatigue scores in Parkinson disease: A randomized controlled trial
Auteurs : Dan A. Mendonça [Canada] ; Krishe Menezes [Canada] ; Mandar S. Jog [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-10-31.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Central Nervous System Stimulants (therapeutic use), Double-Blind Method, Fatigue, Fatigue (drug therapy), Fatigue (etiology), Female, Humans, Male, Methylphenidate, Methylphenidate (therapeutic use), Middle Aged, Nervous system diseases, Parkinson Disease (complications), Parkinson disease, Questionnaires, Retrospective Studies, Severity of Illness Index, Statistics, Nonparametric, fatigue, methylphenidate, randomized controlled trial.
- MESH :
- chemical , therapeutic use : Central Nervous System Stimulants, Methylphenidate.
- complications : Parkinson Disease.
- drug therapy : Fatigue.
- etiology : Fatigue.
- Aged, Double-Blind Method, Female, Humans, Male, Middle Aged, Questionnaires, Retrospective Studies, Severity of Illness Index, Statistics, Nonparametric.
Abstract
Fatigue is a common nonmotor symptom in idiopathic Parkinson disease (IPD) that can prominently affect everyday function. This study was a randomized, double‐blind, placebo‐controlled trial evaluating methylphenidate for the treatment of fatigue in patients with IPD maintained on their regular medications. Thirty‐six patients were randomized to receive either methylphenidate (10 mg three times per day; n = 17) or placebo (n = 19) for 6 weeks. Primary outcomes were the change from baseline on two separate self‐report fatigue questionnaires: the Fatigue Severity Scale (FSS) and the Multidimensional Fatigue Inventory (MFI). Secondary outcomes included the Unified Parkinson Disease Rating Scale (UPDRS) motor score and the five individual domains of the MFI. Fourteen patients in the methylphenidate group and 16 patients in the control group remained on the intervention for the entire study period. In the treatment arm, mean FSS score was reduced by 6.5 points (from a baseline of 43.8) and mean MFI score was reduced by 8.4 points (from a baseline of 51.0). Both these reductions were significant (P < 0.04). Smaller reductions in the placebo group were nonsignificant. Mean UPDRS motor score did not change significantly in either group. Analysis of MFI subscores showed a significant reduction in General Fatigue in the methylphenidate group (P < 0.001). Overall, adverse effects of medication were more frequent in the placebo group. In conclusion, methylphenidate was effective in lowering fatigue scores in patients with IPD following a 6‐week treatment period. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21656
Affiliations:
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This study was a randomized, double‐blind, placebo‐controlled trial evaluating methylphenidate for the treatment of fatigue in patients with IPD maintained on their regular medications. Thirty‐six patients were randomized to receive either methylphenidate (10 mg three times per day; n = 17) or placebo (n = 19) for 6 weeks. Primary outcomes were the change from baseline on two separate self‐report fatigue questionnaires: the Fatigue Severity Scale (FSS) and the Multidimensional Fatigue Inventory (MFI). Secondary outcomes included the Unified Parkinson Disease Rating Scale (UPDRS) motor score and the five individual domains of the MFI. Fourteen patients in the methylphenidate group and 16 patients in the control group remained on the intervention for the entire study period. In the treatment arm, mean FSS score was reduced by 6.5 points (from a baseline of 43.8) and mean MFI score was reduced by 8.4 points (from a baseline of 51.0). Both these reductions were significant (P < 0.04). Smaller reductions in the placebo group were nonsignificant. Mean UPDRS motor score did not change significantly in either group. Analysis of MFI subscores showed a significant reduction in General Fatigue in the methylphenidate group (P < 0.001). Overall, adverse effects of medication were more frequent in the placebo group. In conclusion, methylphenidate was effective in lowering fatigue scores in patients with IPD following a 6‐week treatment period. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Mendonca, Dan A" sort="Mendonca, Dan A" uniqKey="Mendonca D" first="Dan A." last="Mendonça">Dan A. Mendonça</name></noRegion><name sortKey="Jog, Mandar S" sort="Jog, Mandar S" uniqKey="Jog M" first="Mandar S." last="Jog">Mandar S. Jog</name><name sortKey="Menezes, Krishe" sort="Menezes, Krishe" uniqKey="Menezes K" first="Krishe" last="Menezes">Krishe Menezes</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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