Molding the sensory cortex: Spatial acuity improves after botulinum toxin treatment for cervical dystonia
Identifieur interne : 002D39 ( Main/Exploration ); précédent : 002D38; suivant : 002D40Molding the sensory cortex: Spatial acuity improves after botulinum toxin treatment for cervical dystonia
Auteurs : Richard Walsh [Irlande (pays)] ; Michael Hutchinson [Irlande (pays)]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-12-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Acuity, Adult, Aged, Bontoxilysin, Botulinum Toxins, Type A (therapeutic use), Discrimination (Psychology) (physiology), Dystonia, Female, Humans, Johnson–van Boven–Phillips domes, Male, Middle Aged, Molding, Nervous system diseases, Orientation (physiology), Psychomotor Performance (physiology), Somatosensory Cortex (drug effects), Space Perception (physiology), Torticollis (drug therapy), Torticollis (physiopathology), Torticollis (psychology), Treatment, botulinum toxin, dystonia, spatial acuity.
- MESH :
- chemical , therapeutic use : Botulinum Toxins, Type A.
- drug effects : Somatosensory Cortex.
- drug therapy : Torticollis.
- physiology : Discrimination (Psychology), Orientation, Psychomotor Performance, Space Perception.
- physiopathology : Torticollis.
- psychology : Torticollis.
- Adult, Aged, Female, Humans, Male, Middle Aged.
Abstract
Disorganization of sensory cortical somatotopy has been described in adult onset primary torsion dystonia (AOPTD). Although botulinum toxin type A (BTX‐A) acts peripherally, some studies have suggested a central effect. Our primary hypothesis was that sensory cortical reorganization occurs after BTX‐A treatment of AOPTD. Twenty patients with cervical dystonia and 18 healthy age‐matched control patients had spatial discrimination thresholds (SDTs) measured at baseline and monthly for 3 months. Mean baseline SDT (±SD) was 1.75 ±0.76 mm in the dystonia group, greater than the control group mean of 1.323 ± 0.45 mm (P = 0.05). Mean control group SDT did not vary significantly over time. A transient improvement of 23% from baseline (P = 0.005) occurred in the dystonia group 1 month after injection, which did not positively correlate with changes in physician and patient ratings of torticollis severity. The presumed mechanism of SDT improvement is a modulation of afferent cortical inputs from muscle spindles. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21759
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-12-15">2007-12-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">16</biblScope><biblScope unit="page" from="2443">2443</biblScope><biblScope unit="page" to="2446">2446</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">5242D156BD8DCE93E21368F8B07CAF34435B8103</idno><idno type="DOI">10.1002/mds.21759</idno><idno type="ArticleID">MDS21759</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acuity</term><term>Adult</term><term>Aged</term><term>Bontoxilysin</term><term>Botulinum Toxins, Type A (therapeutic use)</term><term>Discrimination (Psychology) (physiology)</term><term>Dystonia</term><term>Female</term><term>Humans</term><term>Johnson–van Boven–Phillips domes</term><term>Male</term><term>Middle Aged</term><term>Molding</term><term>Nervous system diseases</term><term>Orientation (physiology)</term><term>Psychomotor Performance (physiology)</term><term>Somatosensory Cortex (drug effects)</term><term>Space Perception (physiology)</term><term>Torticollis (drug therapy)</term><term>Torticollis (physiopathology)</term><term>Torticollis (psychology)</term><term>Treatment</term><term>botulinum toxin</term><term>dystonia</term><term>spatial acuity</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Botulinum Toxins, Type A</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Somatosensory Cortex</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Torticollis</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Discrimination (Psychology)</term><term>Orientation</term><term>Psychomotor Performance</term><term>Space Perception</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Torticollis</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Torticollis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Acuité</term><term>Bontoxilysin</term><term>Dystonie</term><term>Moulage</term><term>Pathologie du système nerveux</term><term>Traitement</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Disorganization of sensory cortical somatotopy has been described in adult onset primary torsion dystonia (AOPTD). Although botulinum toxin type A (BTX‐A) acts peripherally, some studies have suggested a central effect. Our primary hypothesis was that sensory cortical reorganization occurs after BTX‐A treatment of AOPTD. Twenty patients with cervical dystonia and 18 healthy age‐matched control patients had spatial discrimination thresholds (SDTs) measured at baseline and monthly for 3 months. Mean baseline SDT (±SD) was 1.75 ±0.76 mm in the dystonia group, greater than the control group mean of 1.323 ± 0.45 mm (P = 0.05). Mean control group SDT did not vary significantly over time. A transient improvement of 23% from baseline (P = 0.005) occurred in the dystonia group 1 month after injection, which did not positively correlate with changes in physician and patient ratings of torticollis severity. The presumed mechanism of SDT improvement is a modulation of afferent cortical inputs from muscle spindles. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Irlande (pays)</li></country></list><tree><country name="Irlande (pays)"><noRegion><name sortKey="Walsh, Richard" sort="Walsh, Richard" uniqKey="Walsh R" first="Richard" last="Walsh">Richard Walsh</name></noRegion><name sortKey="Hutchinson, Michael" sort="Hutchinson, Michael" uniqKey="Hutchinson M" first="Michael" last="Hutchinson">Michael Hutchinson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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