Treatment with antiparkinson and antidepressant drugs: A register‐based, pharmaco‐epidemiological study
Identifieur interne : 002B14 ( Main/Exploration ); précédent : 002B13; suivant : 002B15Treatment with antiparkinson and antidepressant drugs: A register‐based, pharmaco‐epidemiological study
Auteurs : Mette Brandt-Christensen [Danemark] ; Kajsa Kvist [Danemark] ; Flemming M Rkeberg Nilsson [Danemark] ; Per Kragh Andersen [Danemark] ; Lars Vedel Kessing [Danemark]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-10-31.
Descripteurs français
- Wicri :
- geographic : Danemark.
English descriptors
- KwdEn :
- Adult, Age Factors, Aged, Aged, 80 and over, Antidepressive Agents (therapeutic use), Antiparkinson Agents (therapeutic use), Confidence Intervals, Denmark (epidemiology), Depressive Disorder (drug therapy), Depressive Disorder (epidemiology), Depressive Disorder (etiology), Epidemiologic Studies, Female, Humans, Longitudinal Studies, Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (epidemiology), Parkinson's disease, Pharmacoepidemiology, Registries, Retrospective Studies, Sex Factors, antidepressant drugs, antiparkinson drugs, depressive disorder, prescription database.
- MESH :
- chemical , therapeutic use : Antidepressive Agents, Antiparkinson Agents.
- geographic , epidemiology : Denmark.
- complications : Parkinson Disease.
- drug therapy : Depressive Disorder, Parkinson Disease.
- epidemiology : Depressive Disorder, Parkinson Disease.
- etiology : Depressive Disorder.
- Adult, Age Factors, Aged, Aged, 80 and over, Confidence Intervals, Epidemiologic Studies, Female, Humans, Longitudinal Studies, Male, Middle Aged, Pharmacoepidemiology, Registries, Retrospective Studies, Sex Factors.
Abstract
Depressive symptoms and major depression are frequent in patients with Parkinson's disease (PD). However, a systematic knowledge about the treatment with antidepressant drugs among PD patients is missing. We estimated the frequency of antidepressant drug treatment in a national sample of persons treated with antiparkinson drugs (APDs). All persons treated with APDs were identified in the national Danish Prescription database. The subsequent risk of treatment with antidepressants was estimated and compared with the risks for two large control groups. The study period was 5 years. In total, 1,029,737 persons were included. Persons who got APDs had significantly increased rate ratios (RR) of subsequent antidepressant drug treatment compared with an unexposed control group (RR: 2.10 (95% CI: 2.04–2.16)) and with persons who got anti‐diabetic drugs [RR: 1.58 (95% CI: 1.51–1.65)]. Persons treated with APDs have higher frequency of antidepressant drug treatment than have controls. With the reservation that data on drug consumption cannot be directly transferred into conclusions about specific diseases, the present study supports results from other population‐based studies of an association between PD and depression. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21472
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-10-31">2007-10-31</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="page" from="2037">2037</biblScope><biblScope unit="page" to="2042">2042</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">230D548050E2D6A377C12912327C67EADE84658D</idno><idno type="DOI">10.1002/mds.21472</idno><idno type="ArticleID">MDS21472</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Antidepressive Agents (therapeutic use)</term><term>Antiparkinson Agents (therapeutic use)</term><term>Confidence Intervals</term><term>Denmark (epidemiology)</term><term>Depressive Disorder (drug therapy)</term><term>Depressive Disorder (epidemiology)</term><term>Depressive Disorder (etiology)</term><term>Epidemiologic Studies</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson's disease</term><term>Pharmacoepidemiology</term><term>Registries</term><term>Retrospective Studies</term><term>Sex Factors</term><term>antidepressant drugs</term><term>antiparkinson drugs</term><term>depressive disorder</term><term>prescription database</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antidepressive Agents</term><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Denmark</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Depressive Disorder</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Depressive Disorder</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Depressive Disorder</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Confidence Intervals</term><term>Epidemiologic Studies</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Pharmacoepidemiology</term><term>Registries</term><term>Retrospective Studies</term><term>Sex Factors</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Danemark</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Depressive symptoms and major depression are frequent in patients with Parkinson's disease (PD). However, a systematic knowledge about the treatment with antidepressant drugs among PD patients is missing. We estimated the frequency of antidepressant drug treatment in a national sample of persons treated with antiparkinson drugs (APDs). All persons treated with APDs were identified in the national Danish Prescription database. The subsequent risk of treatment with antidepressants was estimated and compared with the risks for two large control groups. The study period was 5 years. In total, 1,029,737 persons were included. Persons who got APDs had significantly increased rate ratios (RR) of subsequent antidepressant drug treatment compared with an unexposed control group (RR: 2.10 (95% CI: 2.04–2.16)) and with persons who got anti‐diabetic drugs [RR: 1.58 (95% CI: 1.51–1.65)]. Persons treated with APDs have higher frequency of antidepressant drug treatment than have controls. With the reservation that data on drug consumption cannot be directly transferred into conclusions about specific diseases, the present study supports results from other population‐based studies of an association between PD and depression. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Danemark</li></country></list><tree><country name="Danemark"><noRegion><name sortKey="Brandt Hristensen, Mette" sort="Brandt Hristensen, Mette" uniqKey="Brandt Hristensen M" first="Mette" last="Brandt-Christensen">Mette Brandt-Christensen</name></noRegion><name sortKey="Andersen, Per Kragh" sort="Andersen, Per Kragh" uniqKey="Andersen P" first="Per Kragh" last="Andersen">Per Kragh Andersen</name><name sortKey="Kessing, Lars Vedel" sort="Kessing, Lars Vedel" uniqKey="Kessing L" first="Lars Vedel" last="Kessing">Lars Vedel Kessing</name><name sortKey="Kvist, Kajsa" sort="Kvist, Kajsa" uniqKey="Kvist K" first="Kajsa" last="Kvist">Kajsa Kvist</name><name sortKey="Nilsson, Flemming M Rkeberg" sort="Nilsson, Flemming M Rkeberg" uniqKey="Nilsson F" first="Flemming M Rkeberg" last="Nilsson">Flemming M Rkeberg Nilsson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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