Relevance of COX-2 Gene Expression in Dementia with Lewy Bodies Associated with Alzheimer Pathology
Identifieur interne : 002A57 ( Main/Exploration ); précédent : 002A56; suivant : 002A58Relevance of COX-2 Gene Expression in Dementia with Lewy Bodies Associated with Alzheimer Pathology
Auteurs : Marisa Saldana [Espagne] ; Laura Pujols [Espagne] ; Joaquim Mullol [Espagne] ; Jordi Roca-Ferrer [Espagne] ; Adriana Cardozo [Espagne] ; Esther Aguilar [Espagne] ; Mercè Bonastre [Espagne] ; Concepcio Marin [Espagne]Source :
- Movement disorders [ 0885-3185 ] ; 2008.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
The aim of the present study was to investigate whether cyclooxygenase-2 (COX-2) expression is involved in the pathogenesis of neurodegeneration in dementia with Lewy bodies (DLB) by measuring COX-2 mRNA and protein expression in frontal cortex and substantia nigra pars compacta of DLB and control human brains. DLB cases were classified as pure form or common form according to the absence or the presence of Alzheimer pathology including neurofibrillary tangles and amyloid deposits by Braak staging. Using Western Blot and Real-time Polymerase chain reaction (PCR) analysis, we have shown that cortical COX-2 protein levels were decreased in DLB cases (P < 0.01). However, no differences in nigral COX-2 mRNA expression were observed between control and DLB cases. In conclusion, the present results suggest that in DLB nigral COX-2 mRNA expression does not correlate with dopaminergic neurodegeneration and that the slight changes observed in the common type are probably due to the concomitant AD pathology.
Affiliations:
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<front><div type="abstract" xml:lang="en">The aim of the present study was to investigate whether cyclooxygenase-2 (COX-2) expression is involved in the pathogenesis of neurodegeneration in dementia with Lewy bodies (DLB) by measuring COX-2 mRNA and protein expression in frontal cortex and substantia nigra pars compacta of DLB and control human brains. DLB cases were classified as pure form or common form according to the absence or the presence of Alzheimer pathology including neurofibrillary tangles and amyloid deposits by Braak staging. Using Western Blot and Real-time Polymerase chain reaction (PCR) analysis, we have shown that cortical COX-2 protein levels were decreased in DLB cases (P < 0.01). However, no differences in nigral COX-2 mRNA expression were observed between control and DLB cases. In conclusion, the present results suggest that in DLB nigral COX-2 mRNA expression does not correlate with dopaminergic neurodegeneration and that the slight changes observed in the common type are probably due to the concomitant AD pathology.</div>
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<name sortKey="Aguilar, Esther" sort="Aguilar, Esther" uniqKey="Aguilar E" first="Esther" last="Aguilar">Esther Aguilar</name>
<name sortKey="Aguilar, Esther" sort="Aguilar, Esther" uniqKey="Aguilar E" first="Esther" last="Aguilar">Esther Aguilar</name>
<name sortKey="Bonastre, Merce" sort="Bonastre, Merce" uniqKey="Bonastre M" first="Mercè" last="Bonastre">Mercè Bonastre</name>
<name sortKey="Bonastre, Merce" sort="Bonastre, Merce" uniqKey="Bonastre M" first="Mercè" last="Bonastre">Mercè Bonastre</name>
<name sortKey="Cardozo, Adriana" sort="Cardozo, Adriana" uniqKey="Cardozo A" first="Adriana" last="Cardozo">Adriana Cardozo</name>
<name sortKey="Marin, Concepcio" sort="Marin, Concepcio" uniqKey="Marin C" first="Concepcio" last="Marin">Concepcio Marin</name>
<name sortKey="Marin, Concepcio" sort="Marin, Concepcio" uniqKey="Marin C" first="Concepcio" last="Marin">Concepcio Marin</name>
<name sortKey="Mullol, Joaquim" sort="Mullol, Joaquim" uniqKey="Mullol J" first="Joaquim" last="Mullol">Joaquim Mullol</name>
<name sortKey="Mullol, Joaquim" sort="Mullol, Joaquim" uniqKey="Mullol J" first="Joaquim" last="Mullol">Joaquim Mullol</name>
<name sortKey="Pujols, Laura" sort="Pujols, Laura" uniqKey="Pujols L" first="Laura" last="Pujols">Laura Pujols</name>
<name sortKey="Pujols, Laura" sort="Pujols, Laura" uniqKey="Pujols L" first="Laura" last="Pujols">Laura Pujols</name>
<name sortKey="Roca Ferrer, Jordi" sort="Roca Ferrer, Jordi" uniqKey="Roca Ferrer J" first="Jordi" last="Roca-Ferrer">Jordi Roca-Ferrer</name>
<name sortKey="Roca Ferrer, Jordi" sort="Roca Ferrer, Jordi" uniqKey="Roca Ferrer J" first="Jordi" last="Roca-Ferrer">Jordi Roca-Ferrer</name>
<name sortKey="Saldana, Marisa" sort="Saldana, Marisa" uniqKey="Saldana M" first="Marisa" last="Saldana">Marisa Saldana</name>
</country>
</tree>
</affiliations>
</record>
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