On the structure of motor symptoms of Parkinson's disease
Identifieur interne : 002722 ( Main/Exploration ); précédent : 002721; suivant : 002723On the structure of motor symptoms of Parkinson's disease
Auteurs : Jan Stochl [République tchèque] ; Anne Boomsma [Pays-Bas] ; Evzen Ruzicka [République tchèque] ; Hana Brozova [République tchèque] ; Petr Blahus [République tchèque]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-07-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Dyskinesias (etiology), Dyskinesias (physiopathology), Female, Humans, Hypokinesia (etiology), Male, Middle Aged, Motor Section of the UPDRS, Muscle Rigidity (etiology), Nervous system diseases, Neurologic Examination, Parkinson Disease (complications), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Section, Structural equation modeling, Tremor (etiology), dimensionality, structural equation modeling.
- MESH :
- complications : Parkinson Disease.
- etiology : Dyskinesias, Hypokinesia, Muscle Rigidity, Tremor.
- physiopathology : Dyskinesias, Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Neurologic Examination.
Abstract
This study aims to investigate the structure of the motor symptoms of Parkinson's disease (PD), as measured by the Motor Section of the Unified Parkinson's Disease Rating Scale (UPDRS). The dimensionality of the Motor Section of the UPDRS was studied using structural equation modeling. The UPDRS measures were obtained from 405 patients with PD [237 men (39 “off”, 170 “on”, 28 unknown) and 168 women (21 “off”, 140 “on”, 7 unknown)]. The ordinal character of UPDRS scores and sample size substantiated the use of robust diagonally weighted least squares model estimation. It was shown that the Motor Section of the UPDRS incorporates five main latent symptom factors (rigidity, tremor, bradykinesia of the extremities, axial/gait bradykinesia, speech/hypomimia) plus two additional factors for laterality, which account for asymmetry of tremor, rigidity and bradykinesia of the extremities. Tremor seems to be an independent symptom factor of PD. Other latent variables are substantially correlated. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22029
Affiliations:
- Pays-Bas, République tchèque
- Bohême centrale, Groningue (province)
- Groningue, Prague
- Université de Groningue
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-07-15">2008-07-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1307">1307</biblScope><biblScope unit="page" to="1312">1312</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">FA9046FE03C7E15B4AA50E5002DC671C4B393599</idno><idno type="DOI">10.1002/mds.22029</idno><idno type="ArticleID">MDS22029</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Dyskinesias (etiology)</term><term>Dyskinesias (physiopathology)</term><term>Female</term><term>Humans</term><term>Hypokinesia (etiology)</term><term>Male</term><term>Middle Aged</term><term>Motor Section of the UPDRS</term><term>Muscle Rigidity (etiology)</term><term>Nervous system diseases</term><term>Neurologic Examination</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Section</term><term>Structural equation modeling</term><term>Tremor (etiology)</term><term>dimensionality</term><term>structural equation modeling</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesias</term><term>Hypokinesia</term><term>Muscle Rigidity</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dyskinesias</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Modèle équation structurale</term><term>Pathologie du système nerveux</term><term>Section</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study aims to investigate the structure of the motor symptoms of Parkinson's disease (PD), as measured by the Motor Section of the Unified Parkinson's Disease Rating Scale (UPDRS). The dimensionality of the Motor Section of the UPDRS was studied using structural equation modeling. The UPDRS measures were obtained from 405 patients with PD [237 men (39 “off”, 170 “on”, 28 unknown) and 168 women (21 “off”, 140 “on”, 7 unknown)]. The ordinal character of UPDRS scores and sample size substantiated the use of robust diagonally weighted least squares model estimation. It was shown that the Motor Section of the UPDRS incorporates five main latent symptom factors (rigidity, tremor, bradykinesia of the extremities, axial/gait bradykinesia, speech/hypomimia) plus two additional factors for laterality, which account for asymmetry of tremor, rigidity and bradykinesia of the extremities. Tremor seems to be an independent symptom factor of PD. Other latent variables are substantially correlated. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Pays-Bas</li><li>République tchèque</li></country><region><li>Bohême centrale</li><li>Groningue (province)</li></region><settlement><li>Groningue</li><li>Prague</li></settlement><orgName><li>Université de Groningue</li></orgName></list><tree><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Stochl, Jan" sort="Stochl, Jan" uniqKey="Stochl J" first="Jan" last="Stochl">Jan Stochl</name></region><name sortKey="Blahus, Petr" sort="Blahus, Petr" uniqKey="Blahus P" first="Petr" last="Blahus">Petr Blahus</name><name sortKey="Brozova, Hana" sort="Brozova, Hana" uniqKey="Brozova H" first="Hana" last="Brozova">Hana Brozova</name><name sortKey="Ruzicka, Evzen" sort="Ruzicka, Evzen" uniqKey="Ruzicka E" first="Evzen" last="Ruzicka">Evzen Ruzicka</name></country><country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Boomsma, Anne" sort="Boomsma, Anne" uniqKey="Boomsma A" first="Anne" last="Boomsma">Anne Boomsma</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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