MovDisordV3, Main, Exploration, bibRecord, 002227

Longitudinal study of the levodopa motor response in Parkinson's disease: Relationship between cognitive decline and motor function

Identifieur interne : 002227 ( Main/Exploration ); précédent : 002226; suivant : 002228

Longitudinal study of the levodopa motor response in Parkinson's disease: Relationship between cognitive decline and motor function

Auteurs : Jane E. Alty [Australie] ; Benjamin G. Clissold [Australie] ; Craig D. Mccoll [Australie] ; Katrina A. Reardon [Australie] ; Mark Shiff [Australie] ; Peter A. Kempster [Australie]

Source :

Movement Disorders [ 0885-3185 ] ; 2009-12-15.

RBID : ISTEX:EA11FE342BE454E2E7FAC893B5061DB333F1669C

Descripteurs français

Pascal (Inist)
- Dyskinésie, Démence, Fluctuation, Lévodopa, Maladie de Parkinson, Pathologie du système nerveux, Trouble cognitif.

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Antiparkinson Agents (pharmacology), Antiparkinson Agents (therapeutic use), Cognition Disorders (drug therapy), Cognition Disorders (etiology), Cognitive disorder, Dementia, Dementia (chemically induced), Disability Evaluation, Dyskinesia, Dyskinesias (etiology), Female, Fluctuations, Humans, Levodopa, Levodopa (pharmacology), Levodopa (therapeutic use), Longitudinal Studies, Male, Middle Aged, Motor Activity (drug effects), Nervous system diseases, Parkinson disease, Parkinson's disease, Parkinsonian Disorders (complications), Parkinsonian Disorders (drug therapy), Statistics, Nonparametric, dementia, dyskinesia, levodopa, motor fluctuation.
MESH :
- chemical , pharmacology : Antiparkinson Agents, Levodopa.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- chemically induced : Dementia.
- complications : Parkinsonian Disorders.
- drug effects : Motor Activity.
- drug therapy : Cognition Disorders, Parkinsonian Disorders.
- etiology : Cognition Disorders, Dyskinesias.
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Disability Evaluation, Female, Humans, Longitudinal Studies, Male, Middle Aged, Statistics, Nonparametric.

Abstract

In this prospective study of 34 patients with Parkinson's disease (PD), measurements of the short duration levodopa motor response have been performed every 3 years in defined off states. The mean time from initiation of levodopa treatment was 14.8 years, and 17 patients survived to the latest assessment stage. Off phase motor function worsened at a yearly rate of 2.2% of the maximum disability score. The magnitude of the levodopa response is well preserved as the disease progresses, and patients who developed motor fluctuations maintained better on phase motor function than nonfluctuators (P = 0.01). Ten patients, of whom 5 survive, developed dementia. There was no difference in pretreatment disability or initial levodopa response between demented and nondemented subjects. However, dementia was associated with worse on and off motor disability scores after 11 and 14 years (P < 0.001), and a smaller levodopa response magnitude after 14 years (P = 0.008). The plot of sequential scores shows the association between cognitive decline and accelerating increase in motor disability. This suggests that the advanced phase of PD, when Lewy body pathology involves the cerebral cortex, progresses in an exponential rather than linear fashion. © 2009 Movement Disorder Society

Url:

https://api.istex.fr/document/EA11FE342BE454E2E7FAC893B5061DB333F1669C/fulltext/pdf

DOI: 10.1002/mds.22800

Affiliations:

Australie

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Longitudinal study of the levodopa motor response in Parkinson's disease: Relationship between cognitive decline and motor function</title>
<author><name sortKey="Alty, Jane E" sort="Alty, Jane E" uniqKey="Alty J" first="Jane E." last="Alty">Jane E. Alty</name>
</author>
<author><name sortKey="Clissold, Benjamin G" sort="Clissold, Benjamin G" uniqKey="Clissold B" first="Benjamin G." last="Clissold">Benjamin G. Clissold</name>
</author>
<author><name sortKey="Mccoll, Craig D" sort="Mccoll, Craig D" uniqKey="Mccoll C" first="Craig D." last="Mccoll">Craig D. Mccoll</name>
</author>
<author><name sortKey="Reardon, Katrina A" sort="Reardon, Katrina A" uniqKey="Reardon K" first="Katrina A." last="Reardon">Katrina A. Reardon</name>
</author>
<author><name sortKey="Shiff, Mark" sort="Shiff, Mark" uniqKey="Shiff M" first="Mark" last="Shiff">Mark Shiff</name>
</author>
<author><name sortKey="Kempster, Peter A" sort="Kempster, Peter A" uniqKey="Kempster P" first="Peter A." last="Kempster">Peter A. Kempster</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:EA11FE342BE454E2E7FAC893B5061DB333F1669C</idno>
<date when="2009" year="2009">2009</date>
<idno type="doi">10.1002/mds.22800</idno>
<idno type="url">https://api.istex.fr/document/EA11FE342BE454E2E7FAC893B5061DB333F1669C/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001652</idno>
<idno type="wicri:Area/Istex/Curation">001652</idno>
<idno type="wicri:Area/Istex/Checkpoint">000E29</idno>
<idno type="wicri:doubleKey">0885-3185:2009:Alty J:longitudinal:study:of</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:19890972</idno>
<idno type="wicri:Area/PubMed/Corpus">001B08</idno>
<idno type="wicri:Area/PubMed/Curation">001B08</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001D32</idno>
<idno type="wicri:Area/Ncbi/Merge">002875</idno>
<idno type="wicri:Area/Ncbi/Curation">002875</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002875</idno>
<idno type="wicri:Area/Main/Merge">002A88</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:10-0071269</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000C58</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002061</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000E19</idno>
<idno type="wicri:doubleKey">0885-3185:2009:Alty J:longitudinal:study:of</idno>
<idno type="wicri:Area/Main/Merge">002F16</idno>
<idno type="wicri:Area/Main/Curation">002227</idno>
<idno type="wicri:Area/Main/Exploration">002227</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Longitudinal study of the levodopa motor response in Parkinson's disease: Relationship between cognitive decline and motor function</title>
<author><name sortKey="Alty, Jane E" sort="Alty, Jane E" uniqKey="Alty J" first="Jane E." last="Alty">Jane E. Alty</name>
<affiliation wicri:level="1"><country xml:lang="fr">Australie</country>
<wicri:regionArea>Neurosciences Department, Monash Medical Centre, Clayton, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Clissold, Benjamin G" sort="Clissold, Benjamin G" uniqKey="Clissold B" first="Benjamin G." last="Clissold">Benjamin G. Clissold</name>
<affiliation wicri:level="1"><country xml:lang="fr">Australie</country>
<wicri:regionArea>Neurosciences Department, Monash Medical Centre, Clayton, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mccoll, Craig D" sort="Mccoll, Craig D" uniqKey="Mccoll C" first="Craig D." last="Mccoll">Craig D. Mccoll</name>
<affiliation wicri:level="1"><country xml:lang="fr">Australie</country>
<wicri:regionArea>Neurosciences Department, Monash Medical Centre, Clayton, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Reardon, Katrina A" sort="Reardon, Katrina A" uniqKey="Reardon K" first="Katrina A." last="Reardon">Katrina A. Reardon</name>
<affiliation wicri:level="1"><country xml:lang="fr">Australie</country>
<wicri:regionArea>Neurosciences Department, Monash Medical Centre, Clayton, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shiff, Mark" sort="Shiff, Mark" uniqKey="Shiff M" first="Mark" last="Shiff">Mark Shiff</name>
<affiliation wicri:level="1"><country xml:lang="fr">Australie</country>
<wicri:regionArea>Neurosciences Department, Monash Medical Centre, Clayton, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kempster, Peter A" sort="Kempster, Peter A" uniqKey="Kempster P" first="Peter A." last="Kempster">Peter A. Kempster</name>
<affiliation wicri:level="1"><country xml:lang="fr">Australie</country>
<wicri:regionArea>Neurosciences Department, Monash Medical Centre, Clayton, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2009-12-15">2009-12-15</date>
<biblScope unit="vol">24</biblScope>
<biblScope unit="issue">16</biblScope>
<biblScope unit="page" from="2337">2337</biblScope>
<biblScope unit="page" to="2343">2343</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">EA11FE342BE454E2E7FAC893B5061DB333F1669C</idno>
<idno type="DOI">10.1002/mds.22800</idno>
<idno type="ArticleID">MDS22800</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Analysis of Variance</term>
<term>Antiparkinson Agents (pharmacology)</term>
<term>Antiparkinson Agents (therapeutic use)</term>
<term>Cognition Disorders (drug therapy)</term>
<term>Cognition Disorders (etiology)</term>
<term>Cognitive disorder</term>
<term>Dementia</term>
<term>Dementia (chemically induced)</term>
<term>Disability Evaluation</term>
<term>Dyskinesia</term>
<term>Dyskinesias (etiology)</term>
<term>Female</term>
<term>Fluctuations</term>
<term>Humans</term>
<term>Levodopa</term>
<term>Levodopa (pharmacology)</term>
<term>Levodopa (therapeutic use)</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Activity (drug effects)</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Parkinsonian Disorders (complications)</term>
<term>Parkinsonian Disorders (drug therapy)</term>
<term>Statistics, Nonparametric</term>
<term>dementia</term>
<term>dyskinesia</term>
<term>levodopa</term>
<term>motor fluctuation</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Dementia</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinsonian Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Motor Activity</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Cognition Disorders</term>
<term>Parkinsonian Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term>
<term>Dyskinesias</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Analysis of Variance</term>
<term>Disability Evaluation</term>
<term>Female</term>
<term>Humans</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Statistics, Nonparametric</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Dyskinésie</term>
<term>Démence</term>
<term>Fluctuation</term>
<term>Lévodopa</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Trouble cognitif</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">In this prospective study of 34 patients with Parkinson's disease (PD), measurements of the short duration levodopa motor response have been performed every 3 years in defined off states. The mean time from initiation of levodopa treatment was 14.8 years, and 17 patients survived to the latest assessment stage. Off phase motor function worsened at a yearly rate of 2.2% of the maximum disability score. The magnitude of the levodopa response is well preserved as the disease progresses, and patients who developed motor fluctuations maintained better on phase motor function than nonfluctuators (P = 0.01). Ten patients, of whom 5 survive, developed dementia. There was no difference in pretreatment disability or initial levodopa response between demented and nondemented subjects. However, dementia was associated with worse on and off motor disability scores after 11 and 14 years (P < 0.001), and a smaller levodopa response magnitude after 14 years (P = 0.008). The plot of sequential scores shows the association between cognitive decline and accelerating increase in motor disability. This suggests that the advanced phase of PD, when Lewy body pathology involves the cerebral cortex, progresses in an exponential rather than linear fashion. © 2009 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
</country>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Alty, Jane E" sort="Alty, Jane E" uniqKey="Alty J" first="Jane E." last="Alty">Jane E. Alty</name>
</noRegion>
<name sortKey="Clissold, Benjamin G" sort="Clissold, Benjamin G" uniqKey="Clissold B" first="Benjamin G." last="Clissold">Benjamin G. Clissold</name>
<name sortKey="Kempster, Peter A" sort="Kempster, Peter A" uniqKey="Kempster P" first="Peter A." last="Kempster">Peter A. Kempster</name>
<name sortKey="Mccoll, Craig D" sort="Mccoll, Craig D" uniqKey="Mccoll C" first="Craig D." last="Mccoll">Craig D. Mccoll</name>
<name sortKey="Reardon, Katrina A" sort="Reardon, Katrina A" uniqKey="Reardon K" first="Katrina A." last="Reardon">Katrina A. Reardon</name>
<name sortKey="Shiff, Mark" sort="Shiff, Mark" uniqKey="Shiff M" first="Mark" last="Shiff">Mark Shiff</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002227 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002227 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:EA11FE342BE454E2E7FAC893B5061DB333F1669C
   |texte=   Longitudinal study of the levodopa motor response in Parkinson's disease: Relationship between cognitive decline and motor function
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

Movement Disorders (revue)

Longitudinal study of the levodopa motor response in Parkinson's disease: Relationship between cognitive decline and motor function

Longitudinal study of the levodopa motor response in Parkinson's disease: Relationship between cognitive decline and motor function

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.