MovDisordV3, Main, Exploration, bibRecord, 001C94

Extrapyramidal symptoms in substance abusers with and without schizophrenia and in nonabusing patients with schizophrenia

Identifieur interne : 001C94 ( Main/Exploration ); précédent : 001C93; suivant : 001C95

Extrapyramidal symptoms in substance abusers with and without schizophrenia and in nonabusing patients with schizophrenia

Auteurs : Simon Zhornitsky [Canada] ; Emmanuel Stip [Canada] ; Tania Pampoulova [Canada] ; Élie Rizkallah [Canada] ; Olivier Lipp [Canada] ; Lahcen Aït Bentaleb [Canada] ; Jean-Pierre Chiasson [Canada] ; Stéphane Potvin [Canada]

Source :

Movement Disorders [ 0885-3185 ] ; 2010-10-15.

RBID : ISTEX:8EE4EBD56BCD447F0D1EAAC30A9790ACB7093FCC

English descriptors

KwdEn :
- Adult, Analysis of Variance, Basal Ganglia Diseases (complications), Basal Ganglia Diseases (diagnosis), Basal Ganglia Diseases (epidemiology), Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Schizophrenia (complications), Schizophrenia (epidemiology), Substance-Related Disorders (complications), Substance-Related Disorders (diagnosis), Substance-Related Disorders (epidemiology), antipsychotics, extrapyramidal symptoms, schizophrenia, substance use disorders.
MESH :
- complications : Basal Ganglia Diseases, Schizophrenia, Substance-Related Disorders.
- diagnosis : Basal Ganglia Diseases, Substance-Related Disorders.
- epidemiology : Basal Ganglia Diseases, Schizophrenia, Substance-Related Disorders.
- Adult, Analysis of Variance, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales.

Abstract

Extrapyramidal symptoms (EPS) such as parkinsonism, dystonia, dyskinesia, and akathisia are conditions of impaired motor function, which are associated with chronic antipsychotic treatment in schizophrenia. In addition, EPS is often exacerbated by psychoactive substance (PAS) abuse, which is frequently observed in this population. Few studies, however, have investigated the contribution of PAS abuse on EPS in PAS‐abusers without comorbid psychosis. This study compared the occurrence of EPS in outpatient schizophrenia patients with (DD group; n= 36) and without PAS abuse (SCZ group; n = 41) as well as in nonschizophrenia PAS abusers undergoing detoxification [substance use disorder (SUD) group; n = 38]. Psychiatric symptoms were measured using the Positive and Negative Syndrome Scale and the Calgary Depression Scale for schizophrenia. Extrapyramidal symptoms were evaluated with the Extrapyramidal Symptoms Rating Scale and the Barnes Akathisia Scale. SUD diagnoses were complemented with urine drug screenings. We found that DD patients exhibited significantly more parkinsonism than SCZ patients. Our subanalyses revealed that cocaine and alcohol abuse/dependence was responsible for the increase in parkinsonism in DD patients. Additionally, we found that SUD individuals exhibited significantly more akathisia than SCZ patients. In these latter individuals, subanalyses revealed that alcohol and cannabis abuse/dependence was responsible for the increase in akathisia. Our results suggest that PAS abuse is a contributor to EPS in individuals with and without schizophrenia. © 2010 Movement Disorder Society.

Url:

https://api.istex.fr/document/8EE4EBD56BCD447F0D1EAAC30A9790ACB7093FCC/fulltext/pdf

DOI: 10.1002/mds.23227

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Extrapyramidal symptoms (EPS) such as parkinsonism, dystonia, dyskinesia, and akathisia are conditions of impaired motor function, which are associated with chronic antipsychotic treatment in schizophrenia. In addition, EPS is often exacerbated by psychoactive substance (PAS) abuse, which is frequently observed in this population. Few studies, however, have investigated the contribution of PAS abuse on EPS in PAS‐abusers without comorbid psychosis. This study compared the occurrence of EPS in outpatient schizophrenia patients with (DD group; n= 36) and without PAS abuse (SCZ group; n = 41) as well as in nonschizophrenia PAS abusers undergoing detoxification [substance use disorder (SUD) group; n = 38]. Psychiatric symptoms were measured using the Positive and Negative Syndrome Scale and the Calgary Depression Scale for schizophrenia. Extrapyramidal symptoms were evaluated with the Extrapyramidal Symptoms Rating Scale and the Barnes Akathisia Scale. SUD diagnoses were complemented with urine drug screenings. We found that DD patients exhibited significantly more parkinsonism than SCZ patients. Our subanalyses revealed that cocaine and alcohol abuse/dependence was responsible for the increase in parkinsonism in DD patients. Additionally, we found that SUD individuals exhibited significantly more akathisia than SCZ patients. In these latter individuals, subanalyses revealed that alcohol and cannabis abuse/dependence was responsible for the increase in akathisia. Our results suggest that PAS abuse is a contributor to EPS in individuals with and without schizophrenia. © 2010 Movement Disorder Society.</div>
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Movement Disorders (revue)

Extrapyramidal symptoms in substance abusers with and without schizophrenia and in nonabusing patients with schizophrenia

Extrapyramidal symptoms in substance abusers with and without schizophrenia and in nonabusing patients with schizophrenia

Source :

English descriptors

Abstract

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	Movement Disorders (revue)
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