MovDisordV3, Main, Exploration, bibRecord, 001192

Brain Activation Pattern Related to Gait Disturbances in Parkinson's Disease

Identifieur interne : 001192 ( Main/Exploration ); précédent : 001191; suivant : 001193

Brain Activation Pattern Related to Gait Disturbances in Parkinson's Disease

Auteurs : Julien Cremers [Belgique] ; Kevin D'Ostilio [Belgique] ; Julien Stamatakis [Belgique] ; Valérie Delvaux [Belgique] ; Gaetan Garraux [Belgique]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0423944

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Encéphale, Imagerie mentale, Imagerie RMN.

English descriptors

KwdEn :
- Encephalon, Mental imagery, Nervous system diseases, Nuclear magnetic resonance imaging, Parkinson disease.

Abstract

Gait disturbances represent a therapeutic challenge in Parkinson's disease (PD). To further investigate their underlying pathophysiological mechanisms, we compared brain activation related to mental imagery of gait between 15 PD patients and 15 age-matched controls using a block-design functional MRI experiment. On average, patients showed altered locomotion relatively to controls, as assessed with a standardized gait test that evaluated the severity of PD-related gait disturbances on a 25-m path. The experiment was conducted in the subjects as they rehearsed themselves walking on the same path with a gait pattern similar as that during locomotor evaluation. Imagined walking times were measured on a trial-by-trial basis as a control of behavioral performance. In both groups, mean imagined walking time was not significantly different from that measured during real gait on the path used for evaluation. The between-group comparison of the mental gait activation pattern with reference to mental imagery of standing showed hypoactivations within parieto-occipital regions, along with the left hippocampus, midline/lateral cerebellum, and presumed pedunculopontine nucleus/mesencephalic locomotor area, in patients. More specifically, the activation level of the right posterior parietal cortex located within the impaired gait-related cognitive network decreased proportionally with the severity of gait disturbances scored on the path used for gait evaluation and mental imagery. These novel findings suggest that the right posterior parietal cortex dysfunction is strongly related to the severity of gait disturbances in PD. This region may represent a target for the development of therapeutic interventions for PD-related gait disturbances.

Affiliations:

Belgique

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Gait disturbances represent a therapeutic challenge in Parkinson's disease (PD). To further investigate their underlying pathophysiological mechanisms, we compared brain activation related to mental imagery of gait between 15 PD patients and 15 age-matched controls using a block-design functional MRI experiment. On average, patients showed altered locomotion relatively to controls, as assessed with a standardized gait test that evaluated the severity of PD-related gait disturbances on a 25-m path. The experiment was conducted in the subjects as they rehearsed themselves walking on the same path with a gait pattern similar as that during locomotor evaluation. Imagined walking times were measured on a trial-by-trial basis as a control of behavioral performance. In both groups, mean imagined walking time was not significantly different from that measured during real gait on the path used for evaluation. The between-group comparison of the mental gait activation pattern with reference to mental imagery of standing showed hypoactivations within parieto-occipital regions, along with the left hippocampus, midline/lateral cerebellum, and presumed pedunculopontine nucleus/mesencephalic locomotor area, in patients. More specifically, the activation level of the right posterior parietal cortex located within the impaired gait-related cognitive network decreased proportionally with the severity of gait disturbances scored on the path used for gait evaluation and mental imagery. These novel findings suggest that the right posterior parietal cortex dysfunction is strongly related to the severity of gait disturbances in PD. This region may represent a target for the development of therapeutic interventions for PD-related gait disturbances.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Brain Activation Pattern Related to Gait Disturbances in Parkinson's Disease

Brain Activation Pattern Related to Gait Disturbances in Parkinson's Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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