Decreased Olfactory Bulb Volume in Idiopathic Parkinson's Disease Detected by 3.0-Tesla Magnetic Resonance Imaging
Identifieur interne : 001155 ( Main/Exploration ); précédent : 001154; suivant : 001156Decreased Olfactory Bulb Volume in Idiopathic Parkinson's Disease Detected by 3.0-Tesla Magnetic Resonance Imaging
Auteurs : Stefan Brodoehl [Allemagne] ; Carsten Klingner [Allemagne] ; Gerd F. Volk [Allemagne] ; Thomas Bitter [Allemagne] ; Otto W. Witte [Allemagne] ; Christoph Redecker [Allemagne]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
A number of neuropathological studies have demonstrated that the olfactory system is among the first brain regions affected in Parkinson's disease (PD). These findings correlate with pathophysiological and pathological data that show a loss in olfactory bulb (OB) volume in patients with PD. However, to date, MRI has not been a reliable method for the in vivo detection of this volumetric loss in PD. Using a 3.0-Tesla MRI constructive interference in the steady-state sequence, OB volume was evaluated in patients with PD (n = 16) and healthy control subjects (n = 16). A significant loss of OB volume was observed in patients with PD, compared to the healthy control group (91.2 ± 15.72 versus 131.4 ± 24.56 mm3, respectively). Specifically, decreased height of the left OB appears to be a reliable parameter that is adaptable to clinical practice and significantly correlates with OB volume loss in patients with idiopathic PD. Measuring both the volume and height of the OB by MRI may be a valuable method for the clinical investigation of PD.
Affiliations:
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Volk</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department for Otorhinolaryngology, Jena University Hospital</s1><s2>Jena</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena University Hospital</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Bitter, Thomas" sort="Bitter, Thomas" uniqKey="Bitter T" first="Thomas" last="Bitter">Thomas Bitter</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department for Otorhinolaryngology, Jena University Hospital</s1><s2>Jena</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena University Hospital</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Witte, Otto W" sort="Witte, Otto W" uniqKey="Witte O" first="Otto W." last="Witte">Otto W. Witte</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hans Berger Department of Neurology, Jena University Hospital</s1><s2>Jena</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena University Hospital</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Brain Imaging Center, University of Jena</s1><s2>Jena</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>University of Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Redecker, Christoph" sort="Redecker, Christoph" uniqKey="Redecker C" first="Christoph" last="Redecker">Christoph Redecker</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hans Berger Department of Neurology, Jena University Hospital</s1><s2>Jena</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena University Hospital</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Idiopathic</term><term>Nervous system diseases</term><term>Nuclear magnetic resonance imaging</term><term>Olfactory bulb</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Bulbe olfactif</term><term>Idiopathique</term><term>Imagerie RMN</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A number of neuropathological studies have demonstrated that the olfactory system is among the first brain regions affected in Parkinson's disease (PD). These findings correlate with pathophysiological and pathological data that show a loss in olfactory bulb (OB) volume in patients with PD. However, to date, MRI has not been a reliable method for the in vivo detection of this volumetric loss in PD. Using a 3.0-Tesla MRI constructive interference in the steady-state sequence, OB volume was evaluated in patients with PD (n = 16) and healthy control subjects (n = 16). A significant loss of OB volume was observed in patients with PD, compared to the healthy control group (91.2 ± 15.72 versus 131.4 ± 24.56 mm<sup>3</sup>, respectively). Specifically, decreased height of the left OB appears to be a reliable parameter that is adaptable to clinical practice and significantly correlates with OB volume loss in patients with idiopathic PD. Measuring both the volume and height of the OB by MRI may be a valuable method for the clinical investigation of PD.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Brodoehl, Stefan" sort="Brodoehl, Stefan" uniqKey="Brodoehl S" first="Stefan" last="Brodoehl">Stefan Brodoehl</name></noRegion><name sortKey="Bitter, Thomas" sort="Bitter, Thomas" uniqKey="Bitter T" first="Thomas" last="Bitter">Thomas Bitter</name><name sortKey="Brodoehl, Stefan" sort="Brodoehl, Stefan" uniqKey="Brodoehl S" first="Stefan" last="Brodoehl">Stefan Brodoehl</name><name sortKey="Klingner, Carsten" sort="Klingner, Carsten" uniqKey="Klingner C" first="Carsten" last="Klingner">Carsten Klingner</name><name sortKey="Klingner, Carsten" sort="Klingner, Carsten" uniqKey="Klingner C" first="Carsten" last="Klingner">Carsten Klingner</name><name sortKey="Redecker, Christoph" sort="Redecker, Christoph" uniqKey="Redecker C" first="Christoph" last="Redecker">Christoph Redecker</name><name sortKey="Volk, Gerd F" sort="Volk, Gerd F" uniqKey="Volk G" first="Gerd F." last="Volk">Gerd F. Volk</name><name sortKey="Witte, Otto W" sort="Witte, Otto W" uniqKey="Witte O" first="Otto W." last="Witte">Otto W. Witte</name><name sortKey="Witte, Otto W" sort="Witte, Otto W" uniqKey="Witte O" first="Otto W." last="Witte">Otto W. Witte</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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