MovDisordV3, Main, Exploration, bibRecord, 001048

No Correlation of Substantia Nigra Echogenicity and Nigrostriatal Degradation in Parkinson's Disease

Identifieur interne : 001048 ( Main/Exploration ); précédent : 001047; suivant : 001049

No Correlation of Substantia Nigra Echogenicity and Nigrostriatal Degradation in Parkinson's Disease

Auteurs : Elmar Lobsien [Allemagne] ; Simon Schreiner [Allemagne] ; Michail Plotkin [Allemagne] ; Andreas Kupsch [Allemagne] ; Stephan J. Schreiber [Allemagne] ; Florian Doepp [Allemagne]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0198699

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Locus niger, Tomoscintigraphie émission monophotonique, Photon, Exploration ultrason.

English descriptors

KwdEn :
- Locus niger, Nervous system diseases, Parkinson disease, Photon, Single photon emission tomography, Sonography.

Abstract

Background: Substantia nigra hyperechogenicity assessed by transcranial sonography is a typical finding in up to 90% of patients with idiopathic Parkinson's disease, although its value as a surrogate marker for disease progression in Parkinson's disease is controversial. ¹²³I-FP-CIT-single photon emission computed tomography (SPECT) represents an established para-clinical surrogate marker to quantify the nigrostriatal dopaminergic deficit in Parkinson's disease. Whereas most studies found no correlation between extent of substantia nigra echogenicity and the putaminal FP-CIT binding ratio, a more recent analysis reported opposite results. Methods: In 92 patients with Parkinson's disease the substantia nigra echogenicity was compared with the putaminal FP-CIT binding ratio using an investigator-independent SPECT analysis protocol and with several clinical parameters. Results: No correlation was found between the substantia nigra hyperechogenicity and the FP-CIT binding ratio or the disease severity. Conclusions: Substantia nigra hyperechogenicity does not reflect the degree of the nigrostriatal degeneration or the clinical state of the disease progression.

Affiliations:

Allemagne

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Background: Substantia nigra hyperechogenicity assessed by transcranial sonography is a typical finding in up to 90% of patients with idiopathic Parkinson's disease, although its value as a surrogate marker for disease progression in Parkinson's disease is controversial. <sup>123</sup>
I-FP-CIT-single photon emission computed tomography (SPECT) represents an established para-clinical surrogate marker to quantify the nigrostriatal dopaminergic deficit in Parkinson's disease. Whereas most studies found no correlation between extent of substantia nigra echogenicity and the putaminal FP-CIT binding ratio, a more recent analysis reported opposite results. Methods: In 92 patients with Parkinson's disease the substantia nigra echogenicity was compared with the putaminal FP-CIT binding ratio using an investigator-independent SPECT analysis protocol and with several clinical parameters. Results: No correlation was found between the substantia nigra hyperechogenicity and the FP-CIT binding ratio or the disease severity. Conclusions: Substantia nigra hyperechogenicity does not reflect the degree of the nigrostriatal degeneration or the clinical state of the disease progression.</div>
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<name sortKey="Doepp, Florian" sort="Doepp, Florian" uniqKey="Doepp F" first="Florian" last="Doepp">Florian Doepp</name>
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<name sortKey="Plotkin, Michail" sort="Plotkin, Michail" uniqKey="Plotkin M" first="Michail" last="Plotkin">Michail Plotkin</name>
<name sortKey="Schreiber, Stephan J" sort="Schreiber, Stephan J" uniqKey="Schreiber S" first="Stephan J." last="Schreiber">Stephan J. Schreiber</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

No Correlation of Substantia Nigra Echogenicity and Nigrostriatal Degradation in Parkinson's Disease

No Correlation of Substantia Nigra Echogenicity and Nigrostriatal Degradation in Parkinson's Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri