MovDisordV3, Main, Exploration, bibRecord, 000C49

Progression of cortical thinning in early Parkinson's disease.

Identifieur interne : 000C49 ( Main/Exploration ); précédent : 000C48; suivant : 000C50

Progression of cortical thinning in early Parkinson's disease.

Auteurs : Naroa Ibarretxe-Bilbao [Espagne] ; Carme Junque ; Barbara Segura ; Hugo C. Baggio ; Maria J. Marti ; Francesc Valldeoriola ; Nuria Bargallo ; Eduardo Tolosa

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.

RBID : pubmed:23124622

English descriptors

KwdEn :
- Aged, Atrophy, Cerebral Cortex (pathology), Disease Progression, Female, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging (methods), Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (pathology), Parkinson Disease (physiopathology).
MESH :
- methods : Magnetic Resonance Imaging.
- pathology : Cerebral Cortex, Parkinson Disease.
- physiopathology : Parkinson Disease.
- Aged, Atrophy, Disease Progression, Female, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests.

Abstract

The aim of this study was to investigate the progression of cortical thinning and gray-matter (GM) volume loss in early Parkinson's disease (PD). MRI and neuropsychological assessment were obtained at baseline and follow-up (mean ± standard deviation = 35.50 ± 1.88 months) in a group of 16 early-PD patients (H & Y stage ≤II and disease duration ≤5 years) and 15 healthy controls matched for age, gender, and years of education. FreeSurfer software was used for the analysis of cortical thickness as well as for cortical and subcortical volumetric analyses. Voxel-based morphometry analysis was performed using SPM8. Compared to controls, PD patients showed greater regional cortical thinning in bilateral frontotemporal regions as well as greater over-time total GM loss and amygdalar volume reduction. PD patients and controls presented similar over-time changes in cognitive functioning. In early-PD patients, global GM loss, amygdalar atrophy, and cortical thinning in frontotemporal regions are specifically associated with the PD-degenerative process.

DOI: 10.1002/mds.25240
PubMed: 23124622

Affiliations:

Espagne

Le document en format XML

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<front><div type="abstract" xml:lang="en">The aim of this study was to investigate the progression of cortical thinning and gray-matter (GM) volume loss in early Parkinson's disease (PD). MRI and neuropsychological assessment were obtained at baseline and follow-up (mean ± standard deviation = 35.50 ± 1.88 months) in a group of 16 early-PD patients (H & Y stage ≤II and disease duration ≤5 years) and 15 healthy controls matched for age, gender, and years of education. FreeSurfer software was used for the analysis of cortical thickness as well as for cortical and subcortical volumetric analyses. Voxel-based morphometry analysis was performed using SPM8. Compared to controls, PD patients showed greater regional cortical thinning in bilateral frontotemporal regions as well as greater over-time total GM loss and amygdalar volume reduction. PD patients and controls presented similar over-time changes in cognitive functioning. In early-PD patients, global GM loss, amygdalar atrophy, and cortical thinning in frontotemporal regions are specifically associated with the PD-degenerative process.</div>
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Movement Disorders (revue)

Progression of cortical thinning in early Parkinson's disease.

Progression of cortical thinning in early Parkinson's disease.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.