A multimodal imaging analysis of subcortical gray matter in fragile X premutation carriers
Identifieur interne : 000B31 ( Main/Exploration ); précédent : 000B30; suivant : 000B32A multimodal imaging analysis of subcortical gray matter in fragile X premutation carriers
Auteurs : Jun Yi Wang [États-Unis] ; Randi J. Hagerman [États-Unis] ; Susan M. Rivera [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2013.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Atrophy, Brain (pathology), Diffusion Tensor Imaging, Female, Fragile X Mental Retardation Protein (genetics), Fragile X Syndrome (genetics), Fragile X Syndrome (pathology), Functional Laterality, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Multimodal Imaging, Odds Ratio.
- MESH :
- chemical , genetics : Fragile X Mental Retardation Protein.
- genetics : Fragile X Syndrome.
- pathology : Brain, Fragile X Syndrome.
- Aged, Aged, 80 and over, Atrophy, Diffusion Tensor Imaging, Female, Functional Laterality, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Multimodal Imaging, Odds Ratio.
Abstract
Approximately 40% of males with the fragile X premutation develop fragile X-associated tremor/ataxia syndrome after age 50. Although the thalamus and basal ganglia play a crucial role in movement disorders, their involvement in fragile X premutation carriers has not been systematically investigated.
The current study characterized structural abnormalities associated with fragile X premutation carriers (with and without fragile X-associated tremor/ataxia syndrome) in the thalamus, caudate nucleus, putamen, and globus pallidus using T1-weighted and diffusion tensor imaging.
Male premutation carriers with fragile X-associated tremor/ataxia syndrome showed significant volume atrophy and diffusion-weighted signal loss in all 4 structures compared to the control group. They also exhibited volume atrophy and diffusion-weighted signal loss in the thalamus and striatum compared to the premutation carriers without fragile X-associated tremor/ataxia syndrome. Importantly, many of the measurements exhibited robust correlations with symptom severity, with volume and DWI measurements displaying negative correlations and fractional anisotropy measurements displaying positive correlations.
The current study demonstrated involvement of all 4 subcortical gray matter structures in fragile X-associated tremor/ataxia syndrome, with significant volume atrophy, and possibly iron deposition indicated by the diffusion-weighted signal loss. The significant correlation between the subcortical measurements and symptom severity suggests the benefits of tracking structural changes in the subcortical gray matter in future longitudinal studies for early detection and disease monitoring.
Url:
DOI: 10.1002/mds.25473
PubMed: 23649693
PubMed Central: 3785985
Affiliations:
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Le document en format XML
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Hagerman</name><affiliation wicri:level="2"><nlm:aff id="A2">Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California-Davis Medical Center, Sacramento, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California-Davis Medical Center, Sacramento</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Department of Pediatrics, University of California-Davis, School of Medicine, Sacramento, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pediatrics, University of California-Davis, School of Medicine, Sacramento</wicri:cityArea></affiliation></author><author><name sortKey="Rivera, Susan M" sort="Rivera, Susan M" uniqKey="Rivera S" first="Susan M." last="Rivera">Susan M. Rivera</name><affiliation wicri:level="2"><nlm:aff id="A1">Center for Mind and Brain, University of California-Davis, Davis, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Mind and Brain, University of California-Davis, Davis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California-Davis Medical Center, Sacramento, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California-Davis Medical Center, Sacramento</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Department of Psychology, University of California-Davis, Davis, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Psychology, University of California-Davis, Davis</wicri:cityArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Atrophy</term><term>Brain (pathology)</term><term>Diffusion Tensor Imaging</term><term>Female</term><term>Fragile X Mental Retardation Protein (genetics)</term><term>Fragile X Syndrome (genetics)</term><term>Fragile X Syndrome (pathology)</term><term>Functional Laterality</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Male</term><term>Middle Aged</term><term>Multimodal Imaging</term><term>Odds Ratio</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Fragile X Mental Retardation Protein</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Fragile X Syndrome</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Fragile X Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Atrophy</term><term>Diffusion Tensor Imaging</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Male</term><term>Middle Aged</term><term>Multimodal Imaging</term><term>Odds Ratio</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Approximately 40% of males with the fragile X premutation develop fragile X-associated tremor/ataxia syndrome after age 50. Although the thalamus and basal ganglia play a crucial role in movement disorders, their involvement in fragile X premutation carriers has not been systematically investigated. </p></sec><sec id="S2"><title>Methods</title><p id="P2">The current study characterized structural abnormalities associated with fragile X premutation carriers (with and without fragile X-associated tremor/ataxia syndrome) in the thalamus, caudate nucleus, putamen, and globus pallidus using T1-weighted and diffusion tensor imaging. </p></sec><sec id="S3"><title>Results</title><p id="P3">Male premutation carriers with fragile X-associated tremor/ataxia syndrome showed significant volume atrophy and diffusion-weighted signal loss in all 4 structures compared to the control group. They also exhibited volume atrophy and diffusion-weighted signal loss in the thalamus and striatum compared to the premutation carriers without fragile X-associated tremor/ataxia syndrome. Importantly, many of the measurements exhibited robust correlations with symptom severity, with volume and DWI measurements displaying negative correlations and fractional anisotropy measurements displaying positive correlations. </p></sec><sec id="S4"><title>Conclusions</title><p id="P4">The current study demonstrated involvement of all 4 subcortical gray matter structures in fragile X-associated tremor/ataxia syndrome, with significant volume atrophy, and possibly iron deposition indicated by the diffusion-weighted signal loss. The significant correlation between the subcortical measurements and symptom severity suggests the benefits of tracking structural changes in the subcortical gray matter in future longitudinal studies for early detection and disease monitoring.</p></sec></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Wang, Jun Yi" sort="Wang, Jun Yi" uniqKey="Wang J" first="Jun Yi" last="Wang">Jun Yi Wang</name></region><name sortKey="Hagerman, Randi J" sort="Hagerman, Randi J" uniqKey="Hagerman R" first="Randi J." last="Hagerman">Randi J. Hagerman</name><name sortKey="Hagerman, Randi J" sort="Hagerman, Randi J" uniqKey="Hagerman R" first="Randi J." last="Hagerman">Randi J. Hagerman</name><name sortKey="Rivera, Susan M" sort="Rivera, Susan M" uniqKey="Rivera S" first="Susan M." last="Rivera">Susan M. Rivera</name><name sortKey="Rivera, Susan M" sort="Rivera, Susan M" uniqKey="Rivera S" first="Susan M." last="Rivera">Susan M. Rivera</name><name sortKey="Rivera, Susan M" sort="Rivera, Susan M" uniqKey="Rivera S" first="Susan M." last="Rivera">Susan M. Rivera</name><name sortKey="Wang, Jun Yi" sort="Wang, Jun Yi" uniqKey="Wang J" first="Jun Yi" last="Wang">Jun Yi Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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