Dopamine-angiotensin interactions in the basal ganglia and their relevance for Parkinson's disease.
Identifieur interne : 000A18 ( Main/Exploration ); précédent : 000A17; suivant : 000A19Dopamine-angiotensin interactions in the basal ganglia and their relevance for Parkinson's disease.
Auteurs : Jose L. Labandeira-Garcia [Espagne] ; Jannette Rodriguez-Pallares ; Antonio Dominguez-Meijide ; Rita Valenzuela ; Bego A Villar-Cheda ; Ana I. Rodríguez-PerezSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- Angiotensins (physiology), Basal Ganglia (physiology), Brain (physiopathology), Data Interpretation, Statistical, Dopamine (physiology), Humans, Neostriatum (physiopathology), Paracrine Communication (physiology), Parkinson Disease (physiopathology), Renin-Angiotensin System (physiology), Substantia Nigra (physiopathology).
- MESH :
- chemical , physiology : Angiotensins, Dopamine.
- physiology : Basal Ganglia, Paracrine Communication, Renin-Angiotensin System.
- physiopathology : Brain, Neostriatum, Parkinson Disease, Substantia Nigra.
- Data Interpretation, Statistical, Humans.
Abstract
Renin-angiotensin systems are known to act in many tissues, for example, the blood vessel wall or kidney, where a close interaction between angiotensin and dopamine has been demonstrated. Regulatory interactions between the dopaminergic and renin-angiotensin systems have recently been described in the substantia nigra and striatum. In animal models, dopamine depletion induces compensatory overactivation of the local renin-angiotensin system, which primes microglial responses and neuron vulnerability by activating NADPH-oxidase. Hyperactivation of the local renin-angiotensin system exacerbates the inflammatory microglial response, oxidative stress, and dopaminergic degeneration, all of which are inhibited by angiotensin receptor blockers and inhibitors of angiotensin-converting enzymes. In this review we provide evidence suggesting that the renin-angiotensin system may play an important role in dopamine's mediated neuroinflammation and oxidative stress changes in Parkinson's disease. We suggest that manipulating brain angiotensin may constitute an effective neuroprotective strategy for Parkinson's disease.
DOI: 10.1002/mds.25614
PubMed: 23925977
Affiliations:
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Labandeira-Garcia</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName><orgName type="university">Université de Saint-Jacques-de-Compostelle</orgName></affiliation></author><author><name sortKey="Rodriguez Pallares, Jannette" sort="Rodriguez Pallares, Jannette" uniqKey="Rodriguez Pallares J" first="Jannette" last="Rodriguez-Pallares">Jannette Rodriguez-Pallares</name></author><author><name sortKey="Dominguez Meijide, Antonio" sort="Dominguez Meijide, Antonio" uniqKey="Dominguez Meijide A" first="Antonio" last="Dominguez-Meijide">Antonio Dominguez-Meijide</name></author><author><name sortKey="Valenzuela, Rita" sort="Valenzuela, Rita" uniqKey="Valenzuela R" first="Rita" last="Valenzuela">Rita Valenzuela</name></author><author><name sortKey="Villar Cheda, Bego A" sort="Villar Cheda, Bego A" uniqKey="Villar Cheda B" first="Bego A" last="Villar-Cheda">Bego A Villar-Cheda</name></author><author><name sortKey="Rodriguez Perez, Ana I" sort="Rodriguez Perez, Ana I" uniqKey="Rodriguez Perez A" first="Ana I" last="Rodríguez-Perez">Ana I. 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Regulatory interactions between the dopaminergic and renin-angiotensin systems have recently been described in the substantia nigra and striatum. In animal models, dopamine depletion induces compensatory overactivation of the local renin-angiotensin system, which primes microglial responses and neuron vulnerability by activating NADPH-oxidase. Hyperactivation of the local renin-angiotensin system exacerbates the inflammatory microglial response, oxidative stress, and dopaminergic degeneration, all of which are inhibited by angiotensin receptor blockers and inhibitors of angiotensin-converting enzymes. In this review we provide evidence suggesting that the renin-angiotensin system may play an important role in dopamine's mediated neuroinflammation and oxidative stress changes in Parkinson's disease. We suggest that manipulating brain angiotensin may constitute an effective neuroprotective strategy for Parkinson's disease.</div></front></TEI><affiliations><list><country><li>Espagne</li></country><region><li>Communauté de Madrid</li></region><settlement><li>Madrid</li></settlement><orgName><li>Université de Saint-Jacques-de-Compostelle</li></orgName></list><tree><noCountry><name sortKey="Dominguez Meijide, Antonio" sort="Dominguez Meijide, Antonio" uniqKey="Dominguez Meijide A" first="Antonio" last="Dominguez-Meijide">Antonio Dominguez-Meijide</name><name sortKey="Rodriguez Pallares, Jannette" sort="Rodriguez Pallares, Jannette" uniqKey="Rodriguez Pallares J" first="Jannette" last="Rodriguez-Pallares">Jannette Rodriguez-Pallares</name><name sortKey="Rodriguez Perez, Ana I" sort="Rodriguez Perez, Ana I" uniqKey="Rodriguez Perez A" first="Ana I" last="Rodríguez-Perez">Ana I. Rodríguez-Perez</name><name sortKey="Valenzuela, Rita" sort="Valenzuela, Rita" uniqKey="Valenzuela R" first="Rita" last="Valenzuela">Rita Valenzuela</name><name sortKey="Villar Cheda, Bego A" sort="Villar Cheda, Bego A" uniqKey="Villar Cheda B" first="Bego A" last="Villar-Cheda">Bego A Villar-Cheda</name></noCountry><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Labandeira Garcia, Jose L" sort="Labandeira Garcia, Jose L" uniqKey="Labandeira Garcia J" first="Jose L" last="Labandeira-Garcia">Jose L. Labandeira-Garcia</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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