Nonpharmacological enhancement of cognitive function in Parkinson's disease: a systematic review.
Identifieur interne : 000879 ( Main/Exploration ); précédent : 000878; suivant : 000880Nonpharmacological enhancement of cognitive function in Parkinson's disease: a systematic review.
Auteurs : John V. Hindle [Royaume-Uni] ; Annette Petrelli ; Linda Clare ; Elke KalbeSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- complications : Parkinson Disease.
- etiology : Cognition Disorders.
- methods : Cognitive Therapy, Deep Brain Stimulation.
- therapy : Cognition Disorders.
- Humans, Physical Therapy Modalities, Randomized Controlled Trials as Topic.
Abstract
Cognitive decline and dementia are frequent in patients with Parkinson's disease (PD). The evidence for nonpharmacological therapies in Alzheimer's disease and other dementias has been studied systematically, but the evidence is unclear for their efficacy in cognition and dementia in PD. An international collaboration produced a comprehensive, systematic review of the effectiveness and of nonpharmacological and noninvasive therapies in cognitively intact, cognitively impaired, and PD dementia groups. The interventions included cognitive rehabilitation, physical rehabilitation, exercise, and brain stimulation techniques but excluded invasive treatments, such as surgery and deep brain stimulation. The potential biases and evidence levels for controlled trials (CTs) were analyzed based on Cochrane and National Institute for Health and Clinical Excellence criteria. After exclusions, 18 studies were reviewed, including 5 studies of cognitive training, 4 of exercise and physical therapies, 4 of combined cognitive and physical interventions, and 5 of brain stimulation techniques. The methodology, study populations, interventions, outcomes, control groups, analyses, results, limitations, biases, and evidence levels of all reviewed studies were described. There were 9 CTs, including 6 randomized CTs (RCTs). Although 5 trials showed positive results, only 1 study of cognitive training achieved evidence grading of 1+ with a low risk of bias. There were no studies on PD dementia. Current research on nonpharmacological therapies for cognitive dysfunction and dementia in PD is very limited in quantity and quality. There is an urgent need for rigorous RCTs of nonpharmacological treatments for cognitive impairment and dementia in PD.
DOI: 10.1002/mds.25377
PubMed: 23426759
Affiliations:
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Le document en format XML
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Hindle</name><affiliation wicri:level="1"><nlm:affiliation>School of Medical Sciences, Bangor University, Bangor, United Kingdom. j.v.hindle@bangor.ac.uk</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Medical Sciences, Bangor University, Bangor</wicri:regionArea><wicri:noRegion>Bangor</wicri:noRegion></affiliation></author><author><name sortKey="Petrelli, Annette" sort="Petrelli, Annette" uniqKey="Petrelli A" first="Annette" last="Petrelli">Annette Petrelli</name></author><author><name sortKey="Clare, Linda" sort="Clare, Linda" uniqKey="Clare L" first="Linda" last="Clare">Linda Clare</name></author><author><name sortKey="Kalbe, Elke" sort="Kalbe, Elke" uniqKey="Kalbe E" first="Elke" last="Kalbe">Elke Kalbe</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23426759</idno><idno type="pmid">23426759</idno><idno type="doi">10.1002/mds.25377</idno><idno type="wicri:Area/PubMed/Corpus">000A35</idno><idno type="wicri:Area/PubMed/Curation">000A35</idno><idno type="wicri:Area/PubMed/Checkpoint">000893</idno><idno type="wicri:Area/Ncbi/Merge">003A46</idno><idno type="wicri:Area/Ncbi/Curation">003A46</idno><idno type="wicri:Area/Ncbi/Checkpoint">003A46</idno><idno type="wicri:Area/Main/Merge">000879</idno><idno type="wicri:Area/Main/Curation">000879</idno><idno type="wicri:Area/Main/Exploration">000879</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Nonpharmacological enhancement of cognitive function in Parkinson's disease: a systematic review.</title><author><name sortKey="Hindle, John V" sort="Hindle, John V" uniqKey="Hindle J" first="John V" last="Hindle">John V. Hindle</name><affiliation wicri:level="1"><nlm:affiliation>School of Medical Sciences, Bangor University, Bangor, United Kingdom. j.v.hindle@bangor.ac.uk</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Medical Sciences, Bangor University, Bangor</wicri:regionArea><wicri:noRegion>Bangor</wicri:noRegion></affiliation></author><author><name sortKey="Petrelli, Annette" sort="Petrelli, Annette" uniqKey="Petrelli A" first="Annette" last="Petrelli">Annette Petrelli</name></author><author><name sortKey="Clare, Linda" sort="Clare, Linda" uniqKey="Clare L" first="Linda" last="Clare">Linda Clare</name></author><author><name sortKey="Kalbe, Elke" sort="Kalbe, Elke" uniqKey="Kalbe E" first="Elke" last="Kalbe">Elke Kalbe</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cognition Disorders (etiology)</term><term>Cognition Disorders (therapy)</term><term>Cognitive Therapy (methods)</term><term>Deep Brain Stimulation (methods)</term><term>Humans</term><term>Parkinson Disease (complications)</term><term>Physical Therapy Modalities</term><term>Randomized Controlled Trials as Topic</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Cognitive Therapy</term><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Physical Therapy Modalities</term><term>Randomized Controlled Trials as Topic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cognitive decline and dementia are frequent in patients with Parkinson's disease (PD). The evidence for nonpharmacological therapies in Alzheimer's disease and other dementias has been studied systematically, but the evidence is unclear for their efficacy in cognition and dementia in PD. An international collaboration produced a comprehensive, systematic review of the effectiveness and of nonpharmacological and noninvasive therapies in cognitively intact, cognitively impaired, and PD dementia groups. The interventions included cognitive rehabilitation, physical rehabilitation, exercise, and brain stimulation techniques but excluded invasive treatments, such as surgery and deep brain stimulation. The potential biases and evidence levels for controlled trials (CTs) were analyzed based on Cochrane and National Institute for Health and Clinical Excellence criteria. After exclusions, 18 studies were reviewed, including 5 studies of cognitive training, 4 of exercise and physical therapies, 4 of combined cognitive and physical interventions, and 5 of brain stimulation techniques. The methodology, study populations, interventions, outcomes, control groups, analyses, results, limitations, biases, and evidence levels of all reviewed studies were described. There were 9 CTs, including 6 randomized CTs (RCTs). Although 5 trials showed positive results, only 1 study of cognitive training achieved evidence grading of 1+ with a low risk of bias. There were no studies on PD dementia. Current research on nonpharmacological therapies for cognitive dysfunction and dementia in PD is very limited in quantity and quality. There is an urgent need for rigorous RCTs of nonpharmacological treatments for cognitive impairment and dementia in PD.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><noCountry><name sortKey="Clare, Linda" sort="Clare, Linda" uniqKey="Clare L" first="Linda" last="Clare">Linda Clare</name><name sortKey="Kalbe, Elke" sort="Kalbe, Elke" uniqKey="Kalbe E" first="Elke" last="Kalbe">Elke Kalbe</name><name sortKey="Petrelli, Annette" sort="Petrelli, Annette" uniqKey="Petrelli A" first="Annette" last="Petrelli">Annette Petrelli</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Hindle, John V" sort="Hindle, John V" uniqKey="Hindle J" first="John V" last="Hindle">John V. Hindle</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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