Parkinson's disease: evidence for environmental risk factors.
Identifieur interne : 000857 ( Main/Exploration ); précédent : 000856; suivant : 000858Parkinson's disease: evidence for environmental risk factors.
Auteurs : Karl Kieburtz [États-Unis] ; Kathryn B. WunderleSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- epidemiology : Brain Injuries, Parkinson Disease.
- etiology : Parkinson Disease.
- genetics : Parkinson Disease.
- physiology : Exercise.
- Age Factors, Environment, Environmental Exposure, Gene-Environment Interaction, Humans, Risk Factors.
Abstract
Parkinson's disease (PD) has no known cause. Although recent research has focused particularly on genetic causes of PD, environmental causes also play a role in developing the disease. This article reviews environmental factors that may increase the risk of PD, as well as the evidence behind those factors. Enough evidence exists to suggest that age has a causal relationship to PD. Significant evidence exists that gender, tobacco use, and caffeine consumption are also associated with the development of PD. Other environmental factors (pesticide exposure, occupation, blood urate levels, NSAID use, brain injury, and exercise) have limited or conflicting evidence of a relationship to PD. Future research must not neglect the impact of these environmental factors on the development of PD, especially with respect to potential gene-environment interactions.
DOI: 10.1002/mds.25150
PubMed: 23097348
Affiliations:
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Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Parkinson's disease: evidence for environmental risk factors.</title><author><name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name><affiliation wicri:level="1"><nlm:affiliation>Center for Human Experimental Therapeutics, University of Rochester Medical Center, Rochester, New York 14642, USA. Karl.kieburtz@chet.rochester.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Human Experimental Therapeutics, University of Rochester Medical Center, Rochester, New York 14642</wicri:regionArea><wicri:noRegion>New York 14642</wicri:noRegion></affiliation></author><author><name sortKey="Wunderle, Kathryn B" sort="Wunderle, Kathryn B" uniqKey="Wunderle K" first="Kathryn B" last="Wunderle">Kathryn B. Wunderle</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="doi">10.1002/mds.25150</idno><idno type="RBID">pubmed:23097348</idno><idno type="pmid">23097348</idno><idno type="wicri:Area/PubMed/Corpus">000C01</idno><idno type="wicri:Area/PubMed/Curation">000C01</idno><idno type="wicri:Area/PubMed/Checkpoint">000871</idno><idno type="wicri:Area/Ncbi/Merge">003861</idno><idno type="wicri:Area/Ncbi/Curation">003861</idno><idno type="wicri:Area/Ncbi/Checkpoint">003861</idno><idno type="wicri:Area/Main/Merge">000857</idno><idno type="wicri:Area/Main/Curation">000857</idno><idno type="wicri:Area/Main/Exploration">000857</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Parkinson's disease: evidence for environmental risk factors.</title><author><name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name><affiliation wicri:level="1"><nlm:affiliation>Center for Human Experimental Therapeutics, University of Rochester Medical Center, Rochester, New York 14642, USA. Karl.kieburtz@chet.rochester.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Human Experimental Therapeutics, University of Rochester Medical Center, Rochester, New York 14642</wicri:regionArea><wicri:noRegion>New York 14642</wicri:noRegion></affiliation></author><author><name sortKey="Wunderle, Kathryn B" sort="Wunderle, Kathryn B" uniqKey="Wunderle K" first="Kathryn B" last="Wunderle">Kathryn B. Wunderle</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Brain Injuries (epidemiology)</term><term>Environment</term><term>Environmental Exposure</term><term>Exercise (physiology)</term><term>Gene-Environment Interaction</term><term>Humans</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (etiology)</term><term>Parkinson Disease (genetics)</term><term>Risk Factors</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Brain Injuries</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Exercise</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Environment</term><term>Environmental Exposure</term><term>Gene-Environment Interaction</term><term>Humans</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) has no known cause. Although recent research has focused particularly on genetic causes of PD, environmental causes also play a role in developing the disease. This article reviews environmental factors that may increase the risk of PD, as well as the evidence behind those factors. Enough evidence exists to suggest that age has a causal relationship to PD. Significant evidence exists that gender, tobacco use, and caffeine consumption are also associated with the development of PD. Other environmental factors (pesticide exposure, occupation, blood urate levels, NSAID use, brain injury, and exercise) have limited or conflicting evidence of a relationship to PD. Future research must not neglect the impact of these environmental factors on the development of PD, especially with respect to potential gene-environment interactions.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Wunderle, Kathryn B" sort="Wunderle, Kathryn B" uniqKey="Wunderle K" first="Kathryn B" last="Wunderle">Kathryn B. Wunderle</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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