Rivastigmine is Associated with Restoration of Left Frontal Brain Activity in Parkinson’s Disease
Identifieur interne : 000789 ( Main/Exploration ); précédent : 000788; suivant : 000790Rivastigmine is Associated with Restoration of Left Frontal Brain Activity in Parkinson’s Disease
Auteurs : Katherine L. Possin ; Gail A. Kang ; Christine Guo ; Eric M. Fine ; Andrew J. Trujillo ; Caroline A. Racine ; Reva Wilheim ; Erica T. Johnson ; Jennifer L. Witt ; William W. Seeley ; Bruce L. Miller ; Joel H. KramerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2013.
English descriptors
- KwdEn :
- Arousal (drug effects), Attention (drug effects), Cholinesterase Inhibitors (therapeutic use), Cues, Executive Function (drug effects), Female, Frontal Lobe (drug effects), Functional Laterality, Head Movements (physiology), Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neuroprotective Agents (therapeutic use), Neuropsychological Tests, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson Disease (psychology), Phenylcarbamates (therapeutic use), Psychomotor Performance (drug effects), Recovery of Function, Treatment Outcome.
- MESH :
- chemical , therapeutic use : Cholinesterase Inhibitors, Neuroprotective Agents, Phenylcarbamates.
- drug effects : Arousal, Attention, Executive Function, Frontal Lobe, Psychomotor Performance.
- drug therapy : Parkinson Disease.
- physiology : Head Movements.
- physiopathology : Parkinson Disease.
- psychology : Parkinson Disease.
- Cues, Female, Functional Laterality, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Recovery of Function, Treatment Outcome.
Abstract
To investigate how acetylcholinesterase inhibitor (ChEI) treatment impacts brain function in Parkinson’s disease (PD).
Twelve patients with PD and either dementia or mild cognitive impairment underwent task-free functional magnetic resonance imaging before and after three months of ChEI treatment and were compared to 15 age and sex matched neurologically healthy controls. Regional spontaneous brain activity was measured using the fractional amplitude of low frequency fluctuations.
At baseline, patients showed reduced spontaneous brain activity in regions important for motor control (e.g., caudate, supplementary motor area, precentral gyrus, thalamus), attention and executive functions (e.g., lateral prefrontal cortex), and episodic memory (e.g., precuneus, angular gyrus, hippocampus). After treatment, the patients showed a similar but less extensive pattern of reduced spontaneous brain activity relative to controls. Spontaneous brain activity deficits in the left premotor cortex, inferior frontal gyrus, and supplementary motor area were restored such that the activity was increased post-treatment compared to baseline and was no longer different from controls. Treatment-related increases in left premotor and inferior frontal cortex spontaneous brain activity correlated with parallel reaction time improvement on a test of controlled attention.
PD patients with cognitive impairment show numerous regions of decreased spontaneous brain function compared to controls, and rivastigmine is associated with performance-related normalization in left frontal cortex function.
Url:
DOI: 10.1002/mds.25575
PubMed: 23847120
PubMed Central: 4001926
Affiliations:
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Kang</name><affiliation><nlm:aff id="A1">University of California, San Francisco, Department of Neurology</nlm:aff><wicri:noCountry code="subfield">Department of Neurology</wicri:noCountry></affiliation></author><author><name sortKey="Guo, Christine" sort="Guo, Christine" uniqKey="Guo C" first="Christine" last="Guo">Christine Guo</name><affiliation><nlm:aff id="A1">University of California, San Francisco, Department of Neurology</nlm:aff><wicri:noCountry code="subfield">Department of Neurology</wicri:noCountry></affiliation></author><author><name sortKey="Fine, Eric M" sort="Fine, Eric M" uniqKey="Fine E" first="Eric M." last="Fine">Eric M. Fine</name><affiliation><nlm:aff id="A1">University of California, San Francisco, Department of Neurology</nlm:aff><wicri:noCountry code="subfield">Department of Neurology</wicri:noCountry></affiliation></author><author><name sortKey="Trujillo, Andrew J" sort="Trujillo, Andrew J" uniqKey="Trujillo A" first="Andrew J." last="Trujillo">Andrew J. 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Seeley</name><affiliation><nlm:aff id="A1">University of California, San Francisco, Department of Neurology</nlm:aff><wicri:noCountry code="subfield">Department of Neurology</wicri:noCountry></affiliation></author><author><name sortKey="Miller, Bruce L" sort="Miller, Bruce L" uniqKey="Miller B" first="Bruce L." last="Miller">Bruce L. Miller</name><affiliation><nlm:aff id="A1">University of California, San Francisco, Department of Neurology</nlm:aff><wicri:noCountry code="subfield">Department of Neurology</wicri:noCountry></affiliation></author><author><name sortKey="Kramer, Joel H" sort="Kramer, Joel H" uniqKey="Kramer J" first="Joel H." last="Kramer">Joel H. Kramer</name><affiliation><nlm:aff id="A1">University of California, San Francisco, Department of Neurology</nlm:aff><wicri:noCountry code="subfield">Department of Neurology</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23847120</idno><idno type="pmc">4001926</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001926</idno><idno type="RBID">PMC:4001926</idno><idno type="doi">10.1002/mds.25575</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000335</idno><idno type="wicri:Area/Pmc/Curation">000335</idno><idno type="wicri:Area/Pmc/Checkpoint">000074</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000844</idno><idno type="wicri:Area/PubMed/Curation">000844</idno><idno type="wicri:Area/PubMed/Checkpoint">000808</idno><idno type="wicri:Area/Ncbi/Merge">003C38</idno><idno type="wicri:Area/Ncbi/Curation">003C38</idno><idno type="wicri:Area/Ncbi/Checkpoint">003C38</idno><idno type="wicri:doubleKey">0885-3185:2013:Possin K:rivastigmine:is:associated</idno><idno type="wicri:Area/Main/Merge">000789</idno><idno type="wicri:Area/Main/Curation">000789</idno><idno type="wicri:Area/Main/Exploration">000789</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Rivastigmine is Associated with Restoration of Left Frontal Brain Activity in Parkinson’s Disease</title><author><name sortKey="Possin, Katherine L" sort="Possin, Katherine L" uniqKey="Possin K" first="Katherine L." last="Possin">Katherine L. Possin</name><affiliation><nlm:aff id="A1">University of California, San Francisco, Department of Neurology</nlm:aff><wicri:noCountry code="subfield">Department of Neurology</wicri:noCountry></affiliation></author><author><name sortKey="Kang, Gail A" sort="Kang, Gail A" uniqKey="Kang G" first="Gail A." last="Kang">Gail A. Kang</name><affiliation><nlm:aff id="A1">University of California, San Francisco, Department of Neurology</nlm:aff><wicri:noCountry code="subfield">Department of Neurology</wicri:noCountry></affiliation></author><author><name sortKey="Guo, Christine" sort="Guo, Christine" uniqKey="Guo C" first="Christine" last="Guo">Christine Guo</name><affiliation><nlm:aff id="A1">University of California, San Francisco, Department of Neurology</nlm:aff><wicri:noCountry code="subfield">Department of Neurology</wicri:noCountry></affiliation></author><author><name sortKey="Fine, Eric M" sort="Fine, Eric M" uniqKey="Fine E" first="Eric M." last="Fine">Eric M. Fine</name><affiliation><nlm:aff id="A1">University of California, San Francisco, Department of Neurology</nlm:aff><wicri:noCountry code="subfield">Department of Neurology</wicri:noCountry></affiliation></author><author><name sortKey="Trujillo, Andrew J" sort="Trujillo, Andrew J" uniqKey="Trujillo A" first="Andrew J." last="Trujillo">Andrew J. Trujillo</name><affiliation><nlm:aff id="A1">University of California, San Francisco, Department of Neurology</nlm:aff><wicri:noCountry code="subfield">Department of Neurology</wicri:noCountry></affiliation></author><author><name sortKey="Racine, Caroline A" sort="Racine, Caroline A" uniqKey="Racine C" first="Caroline A." last="Racine">Caroline A. Racine</name><affiliation><nlm:aff id="A1">University of California, San Francisco, Department of Neurology</nlm:aff><wicri:noCountry code="subfield">Department of Neurology</wicri:noCountry></affiliation></author><author><name sortKey="Wilheim, Reva" sort="Wilheim, Reva" uniqKey="Wilheim R" first="Reva" last="Wilheim">Reva Wilheim</name><affiliation><nlm:aff id="A1">University of California, San Francisco, Department of Neurology</nlm:aff><wicri:noCountry code="subfield">Department of Neurology</wicri:noCountry></affiliation></author><author><name sortKey="Johnson, Erica T" sort="Johnson, Erica T" uniqKey="Johnson E" first="Erica T." last="Johnson">Erica T. Johnson</name><affiliation><nlm:aff id="A1">University of California, San Francisco, Department of Neurology</nlm:aff><wicri:noCountry code="subfield">Department of Neurology</wicri:noCountry></affiliation></author><author><name sortKey="Witt, Jennifer L" sort="Witt, Jennifer L" uniqKey="Witt J" first="Jennifer L." last="Witt">Jennifer L. Witt</name><affiliation><nlm:aff id="A1">University of California, San Francisco, Department of Neurology</nlm:aff><wicri:noCountry code="subfield">Department of Neurology</wicri:noCountry></affiliation></author><author><name sortKey="Seeley, William W" sort="Seeley, William W" uniqKey="Seeley W" first="William W." last="Seeley">William W. Seeley</name><affiliation><nlm:aff id="A1">University of California, San Francisco, Department of Neurology</nlm:aff><wicri:noCountry code="subfield">Department of Neurology</wicri:noCountry></affiliation></author><author><name sortKey="Miller, Bruce L" sort="Miller, Bruce L" uniqKey="Miller B" first="Bruce L." last="Miller">Bruce L. Miller</name><affiliation><nlm:aff id="A1">University of California, San Francisco, Department of Neurology</nlm:aff><wicri:noCountry code="subfield">Department of Neurology</wicri:noCountry></affiliation></author><author><name sortKey="Kramer, Joel H" sort="Kramer, Joel H" uniqKey="Kramer J" first="Joel H." last="Kramer">Joel H. Kramer</name><affiliation><nlm:aff id="A1">University of California, San Francisco, Department of Neurology</nlm:aff><wicri:noCountry code="subfield">Department of Neurology</wicri:noCountry></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arousal (drug effects)</term><term>Attention (drug effects)</term><term>Cholinesterase Inhibitors (therapeutic use)</term><term>Cues</term><term>Executive Function (drug effects)</term><term>Female</term><term>Frontal Lobe (drug effects)</term><term>Functional Laterality</term><term>Head Movements (physiology)</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Neuroprotective Agents (therapeutic use)</term><term>Neuropsychological Tests</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (psychology)</term><term>Phenylcarbamates (therapeutic use)</term><term>Psychomotor Performance (drug effects)</term><term>Recovery of Function</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Cholinesterase Inhibitors</term><term>Neuroprotective Agents</term><term>Phenylcarbamates</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Arousal</term><term>Attention</term><term>Executive Function</term><term>Frontal Lobe</term><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Head Movements</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cues</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Recovery of Function</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">To investigate how acetylcholinesterase inhibitor (ChEI) treatment impacts brain function in Parkinson’s disease (PD).</p></sec><sec id="S2"><title>Methods</title><p id="P2">Twelve patients with PD and either dementia or mild cognitive impairment underwent task-free functional magnetic resonance imaging before and after three months of ChEI treatment and were compared to 15 age and sex matched neurologically healthy controls. Regional spontaneous brain activity was measured using the fractional amplitude of low frequency fluctuations.</p></sec><sec id="S3"><title>Results</title><p id="P3">At baseline, patients showed reduced spontaneous brain activity in regions important for motor control (e.g., caudate, supplementary motor area, precentral gyrus, thalamus), attention and executive functions (e.g., lateral prefrontal cortex), and episodic memory (e.g., precuneus, angular gyrus, hippocampus). After treatment, the patients showed a similar but less extensive pattern of reduced spontaneous brain activity relative to controls. Spontaneous brain activity deficits in the left premotor cortex, inferior frontal gyrus, and supplementary motor area were restored such that the activity was increased post-treatment compared to baseline and was no longer different from controls. Treatment-related increases in left premotor and inferior frontal cortex spontaneous brain activity correlated with parallel reaction time improvement on a test of controlled attention.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">PD patients with cognitive impairment show numerous regions of decreased spontaneous brain function compared to controls, and rivastigmine is associated with performance-related normalization in left frontal cortex function.</p></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Fine, Eric M" sort="Fine, Eric M" uniqKey="Fine E" first="Eric M." last="Fine">Eric M. Fine</name><name sortKey="Guo, Christine" sort="Guo, Christine" uniqKey="Guo C" first="Christine" last="Guo">Christine Guo</name><name sortKey="Johnson, Erica T" sort="Johnson, Erica T" uniqKey="Johnson E" first="Erica T." last="Johnson">Erica T. Johnson</name><name sortKey="Kang, Gail A" sort="Kang, Gail A" uniqKey="Kang G" first="Gail A." last="Kang">Gail A. Kang</name><name sortKey="Kramer, Joel H" sort="Kramer, Joel H" uniqKey="Kramer J" first="Joel H." last="Kramer">Joel H. Kramer</name><name sortKey="Miller, Bruce L" sort="Miller, Bruce L" uniqKey="Miller B" first="Bruce L." last="Miller">Bruce L. Miller</name><name sortKey="Possin, Katherine L" sort="Possin, Katherine L" uniqKey="Possin K" first="Katherine L." last="Possin">Katherine L. Possin</name><name sortKey="Racine, Caroline A" sort="Racine, Caroline A" uniqKey="Racine C" first="Caroline A." last="Racine">Caroline A. Racine</name><name sortKey="Seeley, William W" sort="Seeley, William W" uniqKey="Seeley W" first="William W." last="Seeley">William W. Seeley</name><name sortKey="Trujillo, Andrew J" sort="Trujillo, Andrew J" uniqKey="Trujillo A" first="Andrew J." last="Trujillo">Andrew J. Trujillo</name><name sortKey="Wilheim, Reva" sort="Wilheim, Reva" uniqKey="Wilheim R" first="Reva" last="Wilheim">Reva Wilheim</name><name sortKey="Witt, Jennifer L" sort="Witt, Jennifer L" uniqKey="Witt J" first="Jennifer L." last="Witt">Jennifer L. Witt</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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