The Relationship between Balance Control and Vitamin D in Parkinson’s Disease—A Pilot Study
Identifieur interne : 000748 ( Main/Exploration ); précédent : 000747; suivant : 000749The Relationship between Balance Control and Vitamin D in Parkinson’s Disease—A Pilot Study
Auteurs : Amie L. Peterson [États-Unis] ; Martina Mancini [États-Unis] ; Fay B. Horak [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2013.
English descriptors
- KwdEn :
- Aged, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Neurologic Examination, Observation, Parkinson Disease (blood), Parkinson Disease (complications), Pilot Projects, Postural Balance (physiology), Retrospective Studies, Sensation Disorders (etiology), Severity of Illness Index, Statistics as Topic, Statistics, Nonparametric, Vitamin D (blood).
- MESH :
- chemical , blood : Vitamin D.
- blood : Parkinson Disease.
- complications : Parkinson Disease.
- etiology : Sensation Disorders.
- physiology : Postural Balance.
- Aged, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Neurologic Examination, Observation, Pilot Projects, Retrospective Studies, Severity of Illness Index, Statistics as Topic, Statistics, Nonparametric.
Abstract
Balance problems and falls are a major source of morbidity and mortality in patients with Parkinson’s disease. Vitamin D supplementation reduces falls and sway in neurologically intact elderly fallers, but effects in Parkinson’s disease are not established.
To study this relationship and select outcome measures for a vitamin D intervention study, balance function and vitamin D concentration were quantified in a series of Parkinson’s patients in a cross-sectional, observational study. Participants underwent a battery of 5 balance tests.
Serum vitamin D concentrations were correlated inversely with Parkinson’s severity, as measured by the motor Unified Parkinson’s Disease Rating Scale. Among the balance measures, vitamin D concentrations were correlated with automatic posture responses to backwards translation, specifically with response strength and stance weight asymmetry.
These findings support the hypothesis that vitamin D plays a role in balance among patients with Parkinson’s disease and identify specific outcome measures for detecting effects of vitamin D upon balance.
Url:
DOI: 10.1002/mds.25405
PubMed: 23554003
PubMed Central: 3812066
Affiliations:
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Le document en format XML
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Peterson</name><affiliation wicri:level="2"><nlm:aff id="A1">Parkinson’s Center of Oregon, Oregon Health and Science University, Portland, Oregon, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson’s Center of Oregon, Oregon Health and Science University, Portland, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Parkinson’s Disease Research and Education Center, Portland Veterans Affairs Hospital, Portland, Oregon, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson’s Disease Research and Education Center, Portland Veterans Affairs Hospital, Portland, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Mancini, Martina" sort="Mancini, Martina" uniqKey="Mancini M" first="Martina" last="Mancini">Martina Mancini</name><affiliation wicri:level="2"><nlm:aff id="A1">Parkinson’s Center of Oregon, Oregon Health and Science University, Portland, Oregon, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson’s Center of Oregon, Oregon Health and Science University, Portland, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Horak, Fay B" sort="Horak, Fay B" uniqKey="Horak F" first="Fay B." last="Horak">Fay B. Horak</name><affiliation wicri:level="2"><nlm:aff id="A1">Parkinson’s Center of Oregon, Oregon Health and Science University, Portland, Oregon, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson’s Center of Oregon, Oregon Health and Science University, Portland, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23554003</idno><idno type="pmc">3812066</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812066</idno><idno type="RBID">PMC:3812066</idno><idno type="doi">10.1002/mds.25405</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000321</idno><idno type="wicri:Area/Pmc/Curation">000321</idno><idno type="wicri:Area/Pmc/Checkpoint">000059</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000962</idno><idno type="wicri:Area/PubMed/Curation">000962</idno><idno type="wicri:Area/PubMed/Checkpoint">000752</idno><idno type="wicri:Area/Ncbi/Merge">003B19</idno><idno type="wicri:Area/Ncbi/Curation">003B19</idno><idno type="wicri:Area/Ncbi/Checkpoint">003B19</idno><idno type="wicri:doubleKey">0885-3185:2013:Peterson A:the:relationship:between</idno><idno type="wicri:Area/Main/Merge">000748</idno><idno type="wicri:Area/Main/Curation">000748</idno><idno type="wicri:Area/Main/Exploration">000748</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Relationship between Balance Control and Vitamin D in Parkinson’s Disease—A Pilot Study</title><author><name sortKey="Peterson, Amie L" sort="Peterson, Amie L" uniqKey="Peterson A" first="Amie L." last="Peterson">Amie L. Peterson</name><affiliation wicri:level="2"><nlm:aff id="A1">Parkinson’s Center of Oregon, Oregon Health and Science University, Portland, Oregon, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson’s Center of Oregon, Oregon Health and Science University, Portland, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Parkinson’s Disease Research and Education Center, Portland Veterans Affairs Hospital, Portland, Oregon, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson’s Disease Research and Education Center, Portland Veterans Affairs Hospital, Portland, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Mancini, Martina" sort="Mancini, Martina" uniqKey="Mancini M" first="Martina" last="Mancini">Martina Mancini</name><affiliation wicri:level="2"><nlm:aff id="A1">Parkinson’s Center of Oregon, Oregon Health and Science University, Portland, Oregon, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson’s Center of Oregon, Oregon Health and Science University, Portland, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Horak, Fay B" sort="Horak, Fay B" uniqKey="Horak F" first="Fay B." last="Horak">Fay B. Horak</name><affiliation wicri:level="2"><nlm:aff id="A1">Parkinson’s Center of Oregon, Oregon Health and Science University, Portland, Oregon, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson’s Center of Oregon, Oregon Health and Science University, Portland, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Observation</term><term>Parkinson Disease (blood)</term><term>Parkinson Disease (complications)</term><term>Pilot Projects</term><term>Postural Balance (physiology)</term><term>Retrospective Studies</term><term>Sensation Disorders (etiology)</term><term>Severity of Illness Index</term><term>Statistics as Topic</term><term>Statistics, Nonparametric</term><term>Vitamin D (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Vitamin D</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Sensation Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Postural Balance</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Observation</term><term>Pilot Projects</term><term>Retrospective Studies</term><term>Severity of Illness Index</term><term>Statistics as Topic</term><term>Statistics, Nonparametric</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Balance problems and falls are a major source of morbidity and mortality in patients with Parkinson’s disease. Vitamin D supplementation reduces falls and sway in neurologically intact elderly fallers, but effects in Parkinson’s disease are not established.</p></sec><sec id="S2"><title>Methods</title><p id="P2">To study this relationship and select outcome measures for a vitamin D intervention study, balance function and vitamin D concentration were quantified in a series of Parkinson’s patients in a cross-sectional, observational study. Participants underwent a battery of 5 balance tests.</p></sec><sec id="S3"><title>Results</title><p id="P3">Serum vitamin D concentrations were correlated inversely with Parkinson’s severity, as measured by the motor Unified Parkinson’s Disease Rating Scale. Among the balance measures, vitamin D concentrations were correlated with automatic posture responses to backwards translation, specifically with response strength and stance weight asymmetry.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">These findings support the hypothesis that vitamin D plays a role in balance among patients with Parkinson’s disease and identify specific outcome measures for detecting effects of vitamin D upon balance.</p></sec></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Oregon</li></region></list><tree><country name="États-Unis"><region name="Oregon"><name sortKey="Peterson, Amie L" sort="Peterson, Amie L" uniqKey="Peterson A" first="Amie L." last="Peterson">Amie L. Peterson</name></region><name sortKey="Horak, Fay B" sort="Horak, Fay B" uniqKey="Horak F" first="Fay B." last="Horak">Fay B. Horak</name><name sortKey="Mancini, Martina" sort="Mancini, Martina" uniqKey="Mancini M" first="Martina" last="Mancini">Martina Mancini</name><name sortKey="Peterson, Amie L" sort="Peterson, Amie L" uniqKey="Peterson A" first="Amie L." last="Peterson">Amie L. Peterson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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