MovDisordV3, Main, Exploration, bibRecord, 000670

Alimentary, my dear Watson? The challenges of enteric α-synuclein as a Parkinson's disease biomarker.

Identifieur interne : 000670 ( Main/Exploration ); précédent : 000669; suivant : 000671

Alimentary, my dear Watson? The challenges of enteric α-synuclein as a Parkinson's disease biomarker.

Auteurs : Naomi P. Visanji [Canada] ; Connie Marras ; Lili-Naz Hazrati ; Louis W C. Liu ; Anthony E. Lang

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.

RBID : pubmed:24375496

English descriptors

KwdEn :
- Biological Markers (metabolism), Colon (metabolism), Colon (pathology), Enteric Nervous System (metabolism), Enteric Nervous System (pathology), Humans, Parkinson Disease (diagnosis), Parkinson Disease (metabolism), Parkinson Disease (pathology), Prodromal Symptoms, alpha-Synuclein (metabolism).
MESH :
- chemical , metabolism : Biological Markers, alpha-Synuclein.
- diagnosis : Parkinson Disease.
- metabolism : Colon, Enteric Nervous System, Parkinson Disease.
- pathology : Colon, Enteric Nervous System, Parkinson Disease.
- Humans, Prodromal Symptoms.

Abstract

An accurate early diagnostic test for Parkinson's disease (PD) is a critical unmet need. Recently, independent groups using different histological techniques have reported that the presence of alpha-synuclein (α-syn) in colonic biopsy tissue is able to distinguish living patients with PD from those without the disease. In addition, a further study has suggested that the presence of α-syn in colonic biopsy tissue may be evident in early or even prodromal PD. However, several questions remain regarding the translation of these findings into using the assessment of α-syn deposition in the enteric nervous system as a diagnostic biomarker for prodromal PD. Here we address critical issues related to the location and quantification of enteric α-syn, detection of α-syn with currently available histological techniques, timing of detection of α-syn deposition, and, most crucially, whether enteric α-syn can distinguish those with PD from both healthy individuals and individuals with other related diseases. We conclude that, although enteric α-syn is a very exciting prospect, further studies will be vital to determine whether enteric α-syn deposition has the potential to be the biomarker for prodromal PD that the field so desperately seeks.

DOI: 10.1002/mds.25789
PubMed: 24375496

Affiliations:

Canada

Le document en format XML

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<author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name>
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<author><name sortKey="Hazrati, Lili Naz" sort="Hazrati, Lili Naz" uniqKey="Hazrati L" first="Lili-Naz" last="Hazrati">Lili-Naz Hazrati</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Enteric Nervous System (pathology)</term>
<term>Humans</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (pathology)</term>
<term>Prodromal Symptoms</term>
<term>alpha-Synuclein (metabolism)</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biological Markers</term>
<term>alpha-Synuclein</term>
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<term>Enteric Nervous System</term>
<term>Parkinson Disease</term>
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<front><div type="abstract" xml:lang="en">An accurate early diagnostic test for Parkinson's disease (PD) is a critical unmet need. Recently, independent groups using different histological techniques have reported that the presence of alpha-synuclein (α-syn) in colonic biopsy tissue is able to distinguish living patients with PD from those without the disease. In addition, a further study has suggested that the presence of α-syn in colonic biopsy tissue may be evident in early or even prodromal PD. However, several questions remain regarding the translation of these findings into using the assessment of α-syn deposition in the enteric nervous system as a diagnostic biomarker for prodromal PD. Here we address critical issues related to the location and quantification of enteric α-syn, detection of α-syn with currently available histological techniques, timing of detection of α-syn deposition, and, most crucially, whether enteric α-syn can distinguish those with PD from both healthy individuals and individuals with other related diseases. We conclude that, although enteric α-syn is a very exciting prospect, further studies will be vital to determine whether enteric α-syn deposition has the potential to be the biomarker for prodromal PD that the field so desperately seeks.</div>
</front>
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<name sortKey="Liu, Louis W C" sort="Liu, Louis W C" uniqKey="Liu L" first="Louis W C" last="Liu">Louis W C. Liu</name>
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<country name="Canada"><noRegion><name sortKey="Visanji, Naomi P" sort="Visanji, Naomi P" uniqKey="Visanji N" first="Naomi P" last="Visanji">Naomi P. Visanji</name>
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Movement Disorders (revue)

Alimentary, my dear Watson? The challenges of enteric α-synuclein as a Parkinson's disease biomarker.

Alimentary, my dear Watson? The challenges of enteric α-synuclein as a Parkinson's disease biomarker.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.