Cognitive executive impairment and dopaminergic deficits in de novo Parkinson's disease.
Identifieur interne : 000632 ( Main/Exploration ); précédent : 000631; suivant : 000633Cognitive executive impairment and dopaminergic deficits in de novo Parkinson's disease.
Auteurs : Françoise J. Siepel [Norvège] ; Kolbj Rn S. Br Nnick ; Jan Booij ; Bernard M. Ravina ; Alexander V. Lebedev ; Joana B. Pereira ; Renate Grüner ; Dag AarslandSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Cognition Disorders (diagnosis), Cognition Disorders (metabolism), Corpus Striatum (metabolism), Cross-Sectional Studies, Dopamine (metabolism), Dopamine Plasma Membrane Transport Proteins (metabolism), Female, Humans, Male, Middle Aged, Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Tomography, Emission-Computed, Single-Photon (methods), Tropanes (diagnostic use).
- MESH :
- chemical , diagnostic use : Tropanes.
- chemical , metabolism : Dopamine, Dopamine Plasma Membrane Transport Proteins.
- diagnosis : Cognition Disorders, Parkinson Disease.
- metabolism : Cognition Disorders, Corpus Striatum.
- methods : Tomography, Emission-Computed, Single-Photon.
- physiopathology : Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Humans, Male, Middle Aged.
Abstract
Cognitive impairment in Parkinson's disease (PD) is common and does directly impact patients' everyday functioning. However, the underlying mechanisms of early cognitive decline are not known. This study explored the association between striatal dopaminergic deficits and cognitive impairment within a large cohort of early, drug-naïve PD patients and tested the hypothesis that executive dysfunction in PD is associated with striatal dopaminergic depletion. A cross-sectional multicenter cohort of 339 PD patients and 158 healthy controls from the Parkinson's Progression Markers Initiative study was analyzed. Each individual underwent cerebral single-photon emission CT (SPECT) and a standardized neuropsychological assessment with tests of memory as well as visuospatial and executive function. SPECT imaging was performed with [(123) I]FP-CIT, and specific binding ratios in left and right putamen and caudate nucleus were calculated. The association between specific binding ratios, cognitive domain scores, and age was analyzed using Pearson's correlations, partial correlation, and conditional process analysis. A small, but significant, positive association between total striatal dopamine transporter binding and the attention/executive domain was found (r = 0.141; P = 0.009) in PD, but this was not significant after adjusting for age. However, in a moderated mediation model, we found that cognitive executive differences between controls and patients with PD were mediated by an age-moderated striatal dopaminergic deficit. Our findings support the hypothesis that nigrostriatal dopaminergic deficit is associated with executive impairment, but not to memory or visuospatial impairment, in early PD.
DOI: 10.1002/mds.26051
PubMed: 25284687
Affiliations:
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Le document en format XML
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Br Nnick</name></author><author><name sortKey="Booij, Jan" sort="Booij, Jan" uniqKey="Booij J" first="Jan" last="Booij">Jan Booij</name></author><author><name sortKey="Ravina, Bernard M" sort="Ravina, Bernard M" uniqKey="Ravina B" first="Bernard M" last="Ravina">Bernard M. Ravina</name></author><author><name sortKey="Lebedev, Alexander V" sort="Lebedev, Alexander V" uniqKey="Lebedev A" first="Alexander V" last="Lebedev">Alexander V. Lebedev</name></author><author><name sortKey="Pereira, Joana B" sort="Pereira, Joana B" uniqKey="Pereira J" first="Joana B" last="Pereira">Joana B. Pereira</name></author><author><name sortKey="Gruner, Renate" sort="Gruner, Renate" uniqKey="Gruner R" first="Renate" last="Grüner">Renate Grüner</name></author><author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25284687</idno><idno type="pmid">25284687</idno><idno type="doi">10.1002/mds.26051</idno><idno type="wicri:Area/PubMed/Corpus">000370</idno><idno type="wicri:Area/PubMed/Curation">000370</idno><idno type="wicri:Area/PubMed/Checkpoint">000649</idno><idno type="wicri:Area/Ncbi/Merge">004133</idno><idno type="wicri:Area/Ncbi/Curation">004133</idno><idno type="wicri:Area/Ncbi/Checkpoint">004133</idno><idno type="wicri:Area/Main/Merge">000632</idno><idno type="wicri:Area/Main/Curation">000632</idno><idno type="wicri:Area/Main/Exploration">000632</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cognitive executive impairment and dopaminergic deficits in de novo Parkinson's disease.</title><author><name sortKey="Siepel, Francoise J" sort="Siepel, Francoise J" uniqKey="Siepel F" first="Françoise J" last="Siepel">Françoise J. Siepel</name><affiliation wicri:level="1"><nlm:affiliation>Center for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Center for Age-Related Medicine, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Br Nnick, Kolbj Rn S" sort="Br Nnick, Kolbj Rn S" uniqKey="Br Nnick K" first="Kolbj Rn S" last="Br Nnick">Kolbj Rn S. Br Nnick</name></author><author><name sortKey="Booij, Jan" sort="Booij, Jan" uniqKey="Booij J" first="Jan" last="Booij">Jan Booij</name></author><author><name sortKey="Ravina, Bernard M" sort="Ravina, Bernard M" uniqKey="Ravina B" first="Bernard M" last="Ravina">Bernard M. Ravina</name></author><author><name sortKey="Lebedev, Alexander V" sort="Lebedev, Alexander V" uniqKey="Lebedev A" first="Alexander V" last="Lebedev">Alexander V. Lebedev</name></author><author><name sortKey="Pereira, Joana B" sort="Pereira, Joana B" uniqKey="Pereira J" first="Joana B" last="Pereira">Joana B. Pereira</name></author><author><name sortKey="Gruner, Renate" sort="Gruner, Renate" uniqKey="Gruner R" first="Renate" last="Grüner">Renate Grüner</name></author><author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (metabolism)</term><term>Corpus Striatum (metabolism)</term><term>Cross-Sectional Studies</term><term>Dopamine (metabolism)</term><term>Dopamine Plasma Membrane Transport Proteins (metabolism)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Tomography, Emission-Computed, Single-Photon (methods)</term><term>Tropanes (diagnostic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Tropanes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term><term>Dopamine Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cognition Disorders</term><term>Corpus Striatum</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cognitive impairment in Parkinson's disease (PD) is common and does directly impact patients' everyday functioning. However, the underlying mechanisms of early cognitive decline are not known. This study explored the association between striatal dopaminergic deficits and cognitive impairment within a large cohort of early, drug-naïve PD patients and tested the hypothesis that executive dysfunction in PD is associated with striatal dopaminergic depletion. A cross-sectional multicenter cohort of 339 PD patients and 158 healthy controls from the Parkinson's Progression Markers Initiative study was analyzed. Each individual underwent cerebral single-photon emission CT (SPECT) and a standardized neuropsychological assessment with tests of memory as well as visuospatial and executive function. SPECT imaging was performed with [(123) I]FP-CIT, and specific binding ratios in left and right putamen and caudate nucleus were calculated. The association between specific binding ratios, cognitive domain scores, and age was analyzed using Pearson's correlations, partial correlation, and conditional process analysis. A small, but significant, positive association between total striatal dopamine transporter binding and the attention/executive domain was found (r = 0.141; P = 0.009) in PD, but this was not significant after adjusting for age. However, in a moderated mediation model, we found that cognitive executive differences between controls and patients with PD were mediated by an age-moderated striatal dopaminergic deficit. Our findings support the hypothesis that nigrostriatal dopaminergic deficit is associated with executive impairment, but not to memory or visuospatial impairment, in early PD.</div></front></TEI><affiliations><list><country><li>Norvège</li></country></list><tree><noCountry><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name><name sortKey="Booij, Jan" sort="Booij, Jan" uniqKey="Booij J" first="Jan" last="Booij">Jan Booij</name><name sortKey="Br Nnick, Kolbj Rn S" sort="Br Nnick, Kolbj Rn S" uniqKey="Br Nnick K" first="Kolbj Rn S" last="Br Nnick">Kolbj Rn S. Br Nnick</name><name sortKey="Gruner, Renate" sort="Gruner, Renate" uniqKey="Gruner R" first="Renate" last="Grüner">Renate Grüner</name><name sortKey="Lebedev, Alexander V" sort="Lebedev, Alexander V" uniqKey="Lebedev A" first="Alexander V" last="Lebedev">Alexander V. Lebedev</name><name sortKey="Pereira, Joana B" sort="Pereira, Joana B" uniqKey="Pereira J" first="Joana B" last="Pereira">Joana B. Pereira</name><name sortKey="Ravina, Bernard M" sort="Ravina, Bernard M" uniqKey="Ravina B" first="Bernard M" last="Ravina">Bernard M. Ravina</name></noCountry><country name="Norvège"><noRegion><name sortKey="Siepel, Francoise J" sort="Siepel, Francoise J" uniqKey="Siepel F" first="Françoise J" last="Siepel">Françoise J. Siepel</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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