Flt3 ligand does not differentiate between Parkinsonian disorders.
Identifieur interne : 000582 ( Main/Exploration ); précédent : 000581; suivant : 000583Flt3 ligand does not differentiate between Parkinsonian disorders.
Auteurs : Edina Silajdži [Suède] ; Radu Constantinescu ; Björn Holmberg ; Maria Björkqvist ; Oskar HanssonSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- chemical , cerebrospinal fluid : Membrane Proteins.
- cerebrospinal fluid : Multiple System Atrophy, Parkinsonian Disorders, Supranuclear Palsy, Progressive.
- Aged, Analysis of Variance, Humans, Middle Aged, Severity of Illness Index.
Abstract
Differential diagnosis of parkinsonian disorders is challenging because of overlapping symptoms, especially during early stages of disease. No validated biomarkers are available for early and accurate diagnosis of multiple system atrophy and other parkinsonian disorders. It has been reported that flt3 ligand levels in cerebrospinal fluid could clearly differentiate patients with Parkinson's disease from patients with multiple system atrophy, with 99% sensitivity and 95% specificity.
DOI: 10.1002/mds.25948
PubMed: 25044107
Affiliations:
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Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Flt3 ligand does not differentiate between Parkinsonian disorders.</title><author><name sortKey="Silajdzi, Edina" sort="Silajdzi, Edina" uniqKey="Silajdzi E" first="Edina" last="Silajdži">Edina Silajdži</name><affiliation wicri:level="1"><nlm:affiliation>Brain Disease Biomarker Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Brain Disease Biomarker Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Constantinescu, Radu" sort="Constantinescu, Radu" uniqKey="Constantinescu R" first="Radu" last="Constantinescu">Radu Constantinescu</name></author><author><name sortKey="Holmberg, Bjorn" sort="Holmberg, Bjorn" uniqKey="Holmberg B" first="Björn" last="Holmberg">Björn Holmberg</name></author><author><name sortKey="Bjorkqvist, Maria" sort="Bjorkqvist, Maria" uniqKey="Bjorkqvist M" first="Maria" last="Björkqvist">Maria Björkqvist</name></author><author><name sortKey="Hansson, Oskar" sort="Hansson, Oskar" uniqKey="Hansson O" first="Oskar" last="Hansson">Oskar Hansson</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25044107</idno><idno type="pmid">25044107</idno><idno type="doi">10.1002/mds.25948</idno><idno type="wicri:Area/PubMed/Corpus">000446</idno><idno type="wicri:Area/PubMed/Curation">000446</idno><idno type="wicri:Area/PubMed/Checkpoint">000594</idno><idno type="wicri:Area/Ncbi/Merge">004057</idno><idno type="wicri:Area/Ncbi/Curation">004057</idno><idno type="wicri:Area/Ncbi/Checkpoint">004057</idno><idno type="wicri:Area/Main/Merge">000582</idno><idno type="wicri:Area/Main/Curation">000582</idno><idno type="wicri:Area/Main/Exploration">000582</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Flt3 ligand does not differentiate between Parkinsonian disorders.</title><author><name sortKey="Silajdzi, Edina" sort="Silajdzi, Edina" uniqKey="Silajdzi E" first="Edina" last="Silajdži">Edina Silajdži</name><affiliation wicri:level="1"><nlm:affiliation>Brain Disease Biomarker Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Brain Disease Biomarker Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Constantinescu, Radu" sort="Constantinescu, Radu" uniqKey="Constantinescu R" first="Radu" last="Constantinescu">Radu Constantinescu</name></author><author><name sortKey="Holmberg, Bjorn" sort="Holmberg, Bjorn" uniqKey="Holmberg B" first="Björn" last="Holmberg">Björn Holmberg</name></author><author><name sortKey="Bjorkqvist, Maria" sort="Bjorkqvist, Maria" uniqKey="Bjorkqvist M" first="Maria" last="Björkqvist">Maria Björkqvist</name></author><author><name sortKey="Hansson, Oskar" sort="Hansson, Oskar" uniqKey="Hansson O" first="Oskar" last="Hansson">Oskar Hansson</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Humans</term><term>Membrane Proteins (cerebrospinal fluid)</term><term>Middle Aged</term><term>Multiple System Atrophy (cerebrospinal fluid)</term><term>Parkinsonian Disorders (cerebrospinal fluid)</term><term>Severity of Illness Index</term><term>Supranuclear Palsy, Progressive (cerebrospinal fluid)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Membrane Proteins</term></keywords><keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Multiple System Atrophy</term><term>Parkinsonian Disorders</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Humans</term><term>Middle Aged</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Differential diagnosis of parkinsonian disorders is challenging because of overlapping symptoms, especially during early stages of disease. No validated biomarkers are available for early and accurate diagnosis of multiple system atrophy and other parkinsonian disorders. It has been reported that flt3 ligand levels in cerebrospinal fluid could clearly differentiate patients with Parkinson's disease from patients with multiple system atrophy, with 99% sensitivity and 95% specificity.</div></front></TEI><affiliations><list><country><li>Suède</li></country></list><tree><noCountry><name sortKey="Bjorkqvist, Maria" sort="Bjorkqvist, Maria" uniqKey="Bjorkqvist M" first="Maria" last="Björkqvist">Maria Björkqvist</name><name sortKey="Constantinescu, Radu" sort="Constantinescu, Radu" uniqKey="Constantinescu R" first="Radu" last="Constantinescu">Radu Constantinescu</name><name sortKey="Hansson, Oskar" sort="Hansson, Oskar" uniqKey="Hansson O" first="Oskar" last="Hansson">Oskar Hansson</name><name sortKey="Holmberg, Bjorn" sort="Holmberg, Bjorn" uniqKey="Holmberg B" first="Björn" last="Holmberg">Björn Holmberg</name></noCountry><country name="Suède"><noRegion><name sortKey="Silajdzi, Edina" sort="Silajdzi, Edina" uniqKey="Silajdzi E" first="Edina" last="Silajdži">Edina Silajdži</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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