N-methyl-D-aspartate receptor antibodies in post-herpes simplex virus encephalitis neurological relapse.
Identifieur interne : 000504 ( Main/Exploration ); précédent : 000503; suivant : 000505N-methyl-D-aspartate receptor antibodies in post-herpes simplex virus encephalitis neurological relapse.
Auteurs : Yael Hacohen [Royaume-Uni] ; Kumaran Deiva ; Phillipa Pettingill ; Patrick Waters ; Ata Siddiqui ; Pascale Chretien ; Esse Menson ; Jean-Pierre Lin ; Marc Tardieu ; Angela Vincent ; Ming J. LimSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- Adolescent, Anti-N-Methyl-D-Aspartate Receptor Encephalitis (blood), Anti-N-Methyl-D-Aspartate Receptor Encephalitis (immunology), Autoantibodies (blood), Child, Preschool, Encephalitis, Herpes Simplex (blood), Encephalitis, Herpes Simplex (immunology), Female, Humans, Infant, Male, Receptors, N-Methyl-D-Aspartate (immunology), Recurrence.
- MESH :
- chemical , blood : Autoantibodies.
- blood : Anti-N-Methyl-D-Aspartate Receptor Encephalitis, Encephalitis, Herpes Simplex.
- immunology : Anti-N-Methyl-D-Aspartate Receptor Encephalitis, Encephalitis, Herpes Simplex, Receptors, N-Methyl-D-Aspartate.
- Adolescent, Child, Preschool, Female, Humans, Infant, Male, Recurrence.
Abstract
Herpes simplex virus encephalitis (HSVE) is a devastating condition that relapses, often with a chorea in children, despite adequate antiviral treatment. At relapse, evidence of viral replication is frequently absent, suggesting that the relapse may be immune-mediated. Seven children who had a neurological relapse following their initial encephalitis, identified from 20 cases of pediatric HSVE, were studied. Serum and/or cerebrospinal fluid (CSF) were tested for N-methyl-D-aspartate receptor (NMDAR) and other antibodies previously reported in central nervous system autoimmunity. Five of the 7 relapsing children had choreoathetosis; 2 of these were NMDAR antibody-positive, 2 were negative (1 with HSV-positive CSF), and 1 was not available for testing. An additional patient, who relapsed with cognitive regression but with no movement disorder, was also NMDAR antibody-positive. In 2 of the NMDAR antibody-positive patients who were treated at relapse and in 1 who was treated only after 10 years of having a relapsing encephalopathy, a beneficial response was observed. Neurological relapses after HSVE may frequently be immune-mediated, particularly in children with chorea. NMDAR antibodies are common, and immunotherapy may be beneficial.
DOI: 10.1002/mds.25626
PubMed: 24014096
Affiliations:
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Le document en format XML
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<author><name sortKey="Menson, Esse" sort="Menson, Esse" uniqKey="Menson E" first="Esse" last="Menson">Esse Menson</name>
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<front><div type="abstract" xml:lang="en">Herpes simplex virus encephalitis (HSVE) is a devastating condition that relapses, often with a chorea in children, despite adequate antiviral treatment. At relapse, evidence of viral replication is frequently absent, suggesting that the relapse may be immune-mediated. Seven children who had a neurological relapse following their initial encephalitis, identified from 20 cases of pediatric HSVE, were studied. Serum and/or cerebrospinal fluid (CSF) were tested for N-methyl-D-aspartate receptor (NMDAR) and other antibodies previously reported in central nervous system autoimmunity. Five of the 7 relapsing children had choreoathetosis; 2 of these were NMDAR antibody-positive, 2 were negative (1 with HSV-positive CSF), and 1 was not available for testing. An additional patient, who relapsed with cognitive regression but with no movement disorder, was also NMDAR antibody-positive. In 2 of the NMDAR antibody-positive patients who were treated at relapse and in 1 who was treated only after 10 years of having a relapsing encephalopathy, a beneficial response was observed. Neurological relapses after HSVE may frequently be immune-mediated, particularly in children with chorea. NMDAR antibodies are common, and immunotherapy may be beneficial.</div>
</front>
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<name sortKey="Lim, Ming J" sort="Lim, Ming J" uniqKey="Lim M" first="Ming J" last="Lim">Ming J. Lim</name>
<name sortKey="Lin, Jean Pierre" sort="Lin, Jean Pierre" uniqKey="Lin J" first="Jean-Pierre" last="Lin">Jean-Pierre Lin</name>
<name sortKey="Menson, Esse" sort="Menson, Esse" uniqKey="Menson E" first="Esse" last="Menson">Esse Menson</name>
<name sortKey="Pettingill, Phillipa" sort="Pettingill, Phillipa" uniqKey="Pettingill P" first="Phillipa" last="Pettingill">Phillipa Pettingill</name>
<name sortKey="Siddiqui, Ata" sort="Siddiqui, Ata" uniqKey="Siddiqui A" first="Ata" last="Siddiqui">Ata Siddiqui</name>
<name sortKey="Tardieu, Marc" sort="Tardieu, Marc" uniqKey="Tardieu M" first="Marc" last="Tardieu">Marc Tardieu</name>
<name sortKey="Vincent, Angela" sort="Vincent, Angela" uniqKey="Vincent A" first="Angela" last="Vincent">Angela Vincent</name>
<name sortKey="Waters, Patrick" sort="Waters, Patrick" uniqKey="Waters P" first="Patrick" last="Waters">Patrick Waters</name>
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<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Hacohen, Yael" sort="Hacohen, Yael" uniqKey="Hacohen Y" first="Yael" last="Hacohen">Yael Hacohen</name>
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