What Can Biomarkers Tell Us About Cognition in Parkinson's Disease?
Identifieur interne : 000359 ( Main/Exploration ); précédent : 000358; suivant : 000360What Can Biomarkers Tell Us About Cognition in Parkinson's Disease?
Auteurs : Brit Mollenhauer [Allemagne] ; Lynn Rochester [Royaume-Uni] ; Alice Chen-Plotkin [États-Unis] ; David Brooks [Royaume-Uni, Danemark]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2014.
English descriptors
- KwdEn :
- Animals, Biological Markers (metabolism), Cognition (physiology), Cognition Disorders (diagnosis), Cognition Disorders (genetics), Cognition Disorders (metabolism), Genetic Variation (genetics), Humans, Parkinson Disease (complications), Parkinson Disease (diagnosis), Parkinson Disease (genetics), Parkinson Disease (metabolism), Risk.
- MESH :
- chemical , metabolism : Biological Markers.
- complications : Parkinson Disease.
- diagnosis : Cognition Disorders, Parkinson Disease.
- genetics : Cognition Disorders, Genetic Variation, Parkinson Disease.
- metabolism : Cognition Disorders, Parkinson Disease.
- physiology : Cognition.
- Animals, Humans, Risk.
Abstract
Cognitive decline is common in Parkinson's disease (PD), even in the early motor stage, and this non-motor feature impacts quality of life and prognosis tremendously. In this article, we discuss marker candidates for cognitive decline in PD from different angles, including functional and structural imaging techniques, biological fluid markers in cerebrospinal fluid, and blood genetic predictors, as well as gait as a surrogate marker of cognitive decline. Specifically, imaging-based markers of cognitive impairment in PD include cortical atrophy, reduced cortical metabolism, loss of cortical cholinergic and frontal dopaminergic function, as well as an increased cortical amyloid load. Reduced β-amyloid(1-42) in cerebrospinal fluid and lower plasma levels of epidermal growth factor are predictors for cognitive decline in PD. In addition, genetic variation in the apolipoprotein E (
Url:
DOI: 10.1002/mds.25846
PubMed: 24757111
PubMed Central: 4384332
Affiliations:
- Allemagne, Danemark, Royaume-Uni, États-Unis
- Angleterre, Basse-Saxe, Grand Londres, Pennsylvanie
- Göttingen, Londres
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P1">Cognitive decline is common in Parkinson's disease (PD), even in the early motor stage, and this non-motor feature impacts quality of life and prognosis tremendously. In this article, we discuss marker candidates for cognitive decline in PD from different angles, including functional and structural imaging techniques, biological fluid markers in cerebrospinal fluid, and blood genetic predictors, as well as gait as a surrogate marker of cognitive decline. Specifically, imaging-based markers of cognitive impairment in PD include cortical atrophy, reduced cortical metabolism, loss of cortical cholinergic and frontal dopaminergic function, as well as an increased cortical amyloid load. Reduced β-amyloid(1-42) in cerebrospinal fluid and lower plasma levels of epidermal growth factor are predictors for cognitive decline in PD. In addition, genetic variation in the apolipoprotein E (<italic>APOE</italic>
), catechol-O-methyltransferase (<italic>COMT</italic>
), microtubule-associated protein tau (<italic>MAPT</italic>
), and glucocerebrosidase (<italic>GBA</italic>
) genes may confer risk for cognitive impairment in PD; and gait disturbance may also indicate an increased risk for dementia. Other marker candidates have been proposed and are discussed. All of the current studies are hampered by gaps in our knowledge about the molecular causes of cognitive decline, which will have to be considered in future biomarker studies.</p>
</div>
</front>
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