MovDisordV3, Main, Exploration, bibRecord, 000248

Eltoprazine prevents levodopa-induced dyskinesias by reducing striatal glutamate and direct pathway activity.

Identifieur interne : 000248 ( Main/Exploration ); précédent : 000247; suivant : 000249

Eltoprazine prevents levodopa-induced dyskinesias by reducing striatal glutamate and direct pathway activity.

Auteurs : Giovanna Paolone [Italie] ; Alberto Brugnoli [Italie] ; Ludovico Arcuri [Italie] ; Daniela Mercatelli [Italie] ; Michele Morari [Italie]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.

RBID : pubmed:26207892

Abstract

Preclinical and clinical evidence that the serotonergic system plays a major role in levodopa-induced dyskinesias has been provided. Selective serotonin (5-hydroxytryptamine; 5-HT) 5-HT1A or 5-HT1B receptor agonists, and, very recently, the mixed 5-HT1A /5-HT1B receptor agonist, eltoprazine, proved effective in inhibiting l-dopa-induced dyskinesias in experimental animals and parkinsonian patients. Here, we investigate the mechanisms underlying this effect.

DOI: 10.1002/mds.26326
PubMed: 26207892

Affiliations:

Italie

Le document en format XML

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<front><div type="abstract" xml:lang="en">Preclinical and clinical evidence that the serotonergic system plays a major role in levodopa-induced dyskinesias has been provided. Selective serotonin (5-hydroxytryptamine; 5-HT) 5-HT1A or 5-HT1B receptor agonists, and, very recently, the mixed 5-HT1A /5-HT1B receptor agonist, eltoprazine, proved effective in inhibiting l-dopa-induced dyskinesias in experimental animals and parkinsonian patients. Here, we investigate the mechanisms underlying this effect.</div>
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Movement Disorders (revue)

Eltoprazine prevents levodopa-induced dyskinesias by reducing striatal glutamate and direct pathway activity.

Eltoprazine prevents levodopa-induced dyskinesias by reducing striatal glutamate and direct pathway activity.

Source :

Abstract

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