Parkinson's disease correlates with promoter methylation in the α-synuclein gene.
Identifieur interne : 000129 ( Main/Exploration ); précédent : 000128; suivant : 000130Parkinson's disease correlates with promoter methylation in the α-synuclein gene.
Auteurs : Lasse Pihlstr M [Norvège] ; Victoria Berge ; Aina Rengmark ; Mathias ToftSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
Genome-wide association studies have demonstrated association between SNCA variability and susceptibility to Parkinson's disease, but causal mechanisms are unclear. We hypothesized that risk variants affect methylation of a putative promoter in SNCA intron 1, previously highlighted in epigenetic studies of Parkinson's disease.
DOI: 10.1002/mds.26073
PubMed: 25545759
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Genome-wide association studies have demonstrated association between SNCA variability and susceptibility to Parkinson's disease, but causal mechanisms are unclear. We hypothesized that risk variants affect methylation of a putative promoter in SNCA intron 1, previously highlighted in epigenetic studies of Parkinson's disease.</div>
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