Young onset Parkinson's disease
Identifieur interne : 006594 ( Main/Curation ); précédent : 006593; suivant : 006595Young onset Parkinson's disease
Auteurs : Niall Quinn [Royaume-Uni] ; Peter Critchley [Royaume-Uni] ; Marsden [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 1987.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adult, Age Factors, Circadian Rhythm, Degenerative disease, Dementia (etiology), Dyskinesia, Drug-Induced (etiology), Dyskinesias, Human, Humans, Juvenile, Levodopa (adverse effects), Levodopa (therapeutic use), Levodopa therapy, Middle Aged, Nervous system diseases, Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (genetics), Parkinson disease, Parkinson's disease, Pedigree, Response fluctuations, Risk Factors, Tremor (genetics), Young adult.
- MESH :
- chemical , adverse effects : Levodopa.
- complications : Parkinson Disease.
- drug therapy : Parkinson Disease.
- etiology : Dementia, Dyskinesia, Drug-Induced.
- genetics : Parkinson Disease, Tremor.
- chemical , therapeutic use : Levodopa.
- Adult, Age Factors, Circadian Rhythm, Humans, Middle Aged, Pedigree, Risk Factors.
Abstract
We describe a personal series of 60 cases of parkinsonism with onset under the age of 40 years. Known causes for early onset of secondary parkinsonism, such as Wilson's disease or encephalitis, were excluded in every case. Two groups were identified: those with onset after the age of 21 in whom no hereditary factors could be ascertained (56 cases), and those with onset before 21 years all of whom had familial parkinsonism. In neither group have we found any association with prematurely grey hair, hypertension, diabetes, pernicious anaemia, or thyroid disorder. Among their families, we have not found any association with diabetes, pernicious anaemia, or thyroid disorder. We propose that cases of apparent idiopathic Parkinson's disease begining between age 21–40 years should be called “young onset Parkinson's disease.” Twenty percent of such patients in our series had at least one first‐ or second‐degree relative in the same or antecedent generations with parkinsonism, but only 1.5% of their relatives at risk had parkinsonism, which is similar to the prevalence in the general population. Ten percent of these patients had at least one relative with essential tremor, but only 1.6% of their relatives at risk had tremor, which again was similar to the prevalence in the population in general. These patients with young onset Parkinson's disease responded well to levodopa therapy. However, dyskinesias and response fluctuations occurred early and frequently. The prevalence of dyskinesias and response fluctuations was strongly correlated with the duration of levodopa treatment, but not with the duration (or probably the severity) of the disease before levodopa therapy was commenced. The involuntary movements often were severe and frequently were diphasic. Despite long disease duration, the incidence of dementia in young onset patients aged less than 65 years was negligible. We believe that most, if not all, patients in this group have degenerative Lewy body idiopathic Parkinson's disease, representing the lower end of a skewed deviation for age of onset of this disease. We have so far failed to identify any additional environmental factor which may have accelerated disease onset in these patients. In contrast, cases of parkinsonism beginning before age 21 years were invariably familial. We proposed that they should be called “juvenile parkinsonism.” All affected relatives with parkinsonism also had young disease onset, and all but one were siblings. None of four such patients seen by us has demented, and computed tomography (CT) scan has been normal in all four. We believe that most such patients have some form of genetically determined secondary parkinsonism.
Url:
DOI: 10.1002/mds.870020201
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000202
- to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :000202
- to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :004567
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :005072
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :005072
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :005055
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :004666
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :004666
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :004666
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :009979
- to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003B07
- to stream PascalFrancis, to step Curation: Pour aller vers cette notice dans l'étape Curation :002D18
- to stream PascalFrancis, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003A65
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :009A24
Links to Exploration step
ISTEX:9D4D1B28D9C8AFA8EB9C065678BD6C0B71299D49Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Young onset Parkinson's disease</title>
<author><name sortKey="Quinn, Niall" sort="Quinn, Niall" uniqKey="Quinn N" first="Niall" last="Quinn">Niall Quinn</name>
</author>
<author><name sortKey="Critchley, Peter" sort="Critchley, Peter" uniqKey="Critchley P" first="Peter" last="Critchley">Peter Critchley</name>
</author>
<author><name sortKey="Marsden" sort="Marsden" uniqKey="Marsden" last="Marsden">Marsden</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:9D4D1B28D9C8AFA8EB9C065678BD6C0B71299D49</idno>
<date when="1987" year="1987">1987</date>
<idno type="doi">10.1002/mds.870020201</idno>
<idno type="url">https://api.istex.fr/document/9D4D1B28D9C8AFA8EB9C065678BD6C0B71299D49/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000202</idno>
<idno type="wicri:Area/Istex/Curation">000202</idno>
<idno type="wicri:Area/Istex/Checkpoint">004567</idno>
<idno type="wicri:doubleKey">0885-3185:1987:Quinn N:young:onset:parkinson</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:3504266</idno>
<idno type="wicri:Area/PubMed/Corpus">005072</idno>
<idno type="wicri:Area/PubMed/Curation">005072</idno>
<idno type="wicri:Area/PubMed/Checkpoint">005055</idno>
<idno type="wicri:Area/Ncbi/Merge">004666</idno>
<idno type="wicri:Area/Ncbi/Curation">004666</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">004666</idno>
<idno type="wicri:doubleKey">0885-3185:1987:Quinn N:young:onset:parkinson</idno>
<idno type="wicri:Area/Main/Merge">009979</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:87-0379158</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">003B07</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002D18</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">003A65</idno>
<idno type="wicri:doubleKey">0885-3185:1987:Quinn N:young:onset:parkinson</idno>
<idno type="wicri:Area/Main/Merge">009A24</idno>
<idno type="wicri:Area/Main/Curation">006594</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Young onset Parkinson's disease</title>
<author><name sortKey="Quinn, Niall" sort="Quinn, Niall" uniqKey="Quinn N" first="Niall" last="Quinn">Niall Quinn</name>
<affiliation wicri:level="2"><country>Royaume-Uni</country>
<placeName><region type="country">Angleterre</region>
</placeName>
<wicri:cityArea>MRC Movement Disorders Research Group, University Department of Neurology, and Parkinson's Disease Society Research Centre, Institute of Psychiatry and King's College Hospital Medical School, London</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Critchley, Peter" sort="Critchley, Peter" uniqKey="Critchley P" first="Peter" last="Critchley">Peter Critchley</name>
<affiliation wicri:level="2"><country>Royaume-Uni</country>
<placeName><region type="country">Angleterre</region>
</placeName>
<wicri:cityArea>MRC Movement Disorders Research Group, University Department of Neurology, and Parkinson's Disease Society Research Centre, Institute of Psychiatry and King's College Hospital Medical School, London</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Marsden" sort="Marsden" uniqKey="Marsden" last="Marsden">Marsden</name>
<affiliation wicri:level="2"><country>Royaume-Uni</country>
<placeName><region type="country">Angleterre</region>
</placeName>
<wicri:cityArea>MRC Movement Disorders Research Group, University Department of Neurology, and Parkinson's Disease Society Research Centre, Institute of Psychiatry and King's College Hospital Medical School, London</wicri:cityArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="1987">1987</date>
<biblScope unit="vol">2</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="73">73</biblScope>
<biblScope unit="page" to="91">91</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">9D4D1B28D9C8AFA8EB9C065678BD6C0B71299D49</idno>
<idno type="DOI">10.1002/mds.870020201</idno>
<idno type="ArticleID">MDS870020201</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Age Factors</term>
<term>Circadian Rhythm</term>
<term>Degenerative disease</term>
<term>Dementia (etiology)</term>
<term>Dyskinesia, Drug-Induced (etiology)</term>
<term>Dyskinesias</term>
<term>Human</term>
<term>Humans</term>
<term>Juvenile</term>
<term>Levodopa (adverse effects)</term>
<term>Levodopa (therapeutic use)</term>
<term>Levodopa therapy</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Pedigree</term>
<term>Response fluctuations</term>
<term>Risk Factors</term>
<term>Tremor (genetics)</term>
<term>Young adult</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Levodopa</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dementia</term>
<term>Dyskinesia, Drug-Induced</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term>
<term>Tremor</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Levodopa</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Age Factors</term>
<term>Circadian Rhythm</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Pedigree</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Adulte jeune</term>
<term>Homme</term>
<term>Maladie dégénérative</term>
<term>Parkinson maladie</term>
<term>Système nerveux pathologie</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We describe a personal series of 60 cases of parkinsonism with onset under the age of 40 years. Known causes for early onset of secondary parkinsonism, such as Wilson's disease or encephalitis, were excluded in every case. Two groups were identified: those with onset after the age of 21 in whom no hereditary factors could be ascertained (56 cases), and those with onset before 21 years all of whom had familial parkinsonism. In neither group have we found any association with prematurely grey hair, hypertension, diabetes, pernicious anaemia, or thyroid disorder. Among their families, we have not found any association with diabetes, pernicious anaemia, or thyroid disorder. We propose that cases of apparent idiopathic Parkinson's disease begining between age 21–40 years should be called “young onset Parkinson's disease.” Twenty percent of such patients in our series had at least one first‐ or second‐degree relative in the same or antecedent generations with parkinsonism, but only 1.5% of their relatives at risk had parkinsonism, which is similar to the prevalence in the general population. Ten percent of these patients had at least one relative with essential tremor, but only 1.6% of their relatives at risk had tremor, which again was similar to the prevalence in the population in general. These patients with young onset Parkinson's disease responded well to levodopa therapy. However, dyskinesias and response fluctuations occurred early and frequently. The prevalence of dyskinesias and response fluctuations was strongly correlated with the duration of levodopa treatment, but not with the duration (or probably the severity) of the disease before levodopa therapy was commenced. The involuntary movements often were severe and frequently were diphasic. Despite long disease duration, the incidence of dementia in young onset patients aged less than 65 years was negligible. We believe that most, if not all, patients in this group have degenerative Lewy body idiopathic Parkinson's disease, representing the lower end of a skewed deviation for age of onset of this disease. We have so far failed to identify any additional environmental factor which may have accelerated disease onset in these patients. In contrast, cases of parkinsonism beginning before age 21 years were invariably familial. We proposed that they should be called “juvenile parkinsonism.” All affected relatives with parkinsonism also had young disease onset, and all but one were siblings. None of four such patients seen by us has demented, and computed tomography (CT) scan has been normal in all four. We believe that most such patients have some form of genetically determined secondary parkinsonism.</div>
</front>
</TEI>
<double idat="0885-3185:1987:Quinn N:young:onset:parkinson"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Young onset Parkinson's disease</title>
<author><name sortKey="Quinn, N" sort="Quinn, N" uniqKey="Quinn N" first="N." last="Quinn">N. Quinn</name>
</author>
<author><name sortKey="Critchley, P" sort="Critchley, P" uniqKey="Critchley P" first="P." last="Critchley">P. Critchley</name>
</author>
<author><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C. D." last="Marsden">C. D. Marsden</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">87-0379158</idno>
<date when="1987">1987</date>
<idno type="stanalyst">PASCAL 87-0379158 INIST</idno>
<idno type="RBID">Pascal:87-0379158</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">003B07</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002D18</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">003A65</idno>
<idno type="wicri:doubleKey">0885-3185:1987:Quinn N:young:onset:parkinson</idno>
<idno type="wicri:Area/Main/Merge">009A24</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Young onset Parkinson's disease</title>
<author><name sortKey="Quinn, N" sort="Quinn, N" uniqKey="Quinn N" first="N." last="Quinn">N. Quinn</name>
</author>
<author><name sortKey="Critchley, P" sort="Critchley, P" uniqKey="Critchley P" first="P." last="Critchley">P. Critchley</name>
</author>
<author><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C. D." last="Marsden">C. D. Marsden</name>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="1987">1987</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Degenerative disease</term>
<term>Human</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Young adult</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Adulte jeune</term>
<term>Maladie dégénérative</term>
<term>Système nerveux pathologie</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
</TEI>
</INIST>
<ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Young onset Parkinson's disease</title>
<author><name sortKey="Quinn, Niall" sort="Quinn, Niall" uniqKey="Quinn N" first="Niall" last="Quinn">Niall Quinn</name>
</author>
<author><name sortKey="Critchley, Peter" sort="Critchley, Peter" uniqKey="Critchley P" first="Peter" last="Critchley">Peter Critchley</name>
</author>
<author><name sortKey="Marsden" sort="Marsden" uniqKey="Marsden" last="Marsden">Marsden</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:9D4D1B28D9C8AFA8EB9C065678BD6C0B71299D49</idno>
<date when="1987" year="1987">1987</date>
<idno type="doi">10.1002/mds.870020201</idno>
<idno type="url">https://api.istex.fr/document/9D4D1B28D9C8AFA8EB9C065678BD6C0B71299D49/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000202</idno>
<idno type="wicri:Area/Istex/Curation">000202</idno>
<idno type="wicri:Area/Istex/Checkpoint">004567</idno>
<idno type="wicri:doubleKey">0885-3185:1987:Quinn N:young:onset:parkinson</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:3504266</idno>
<idno type="wicri:Area/PubMed/Corpus">005072</idno>
<idno type="wicri:Area/PubMed/Curation">005072</idno>
<idno type="wicri:Area/PubMed/Checkpoint">005055</idno>
<idno type="wicri:Area/Ncbi/Merge">004666</idno>
<idno type="wicri:Area/Ncbi/Curation">004666</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">004666</idno>
<idno type="wicri:doubleKey">0885-3185:1987:Quinn N:young:onset:parkinson</idno>
<idno type="wicri:Area/Main/Merge">009979</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Young onset Parkinson's disease</title>
<author><name sortKey="Quinn, Niall" sort="Quinn, Niall" uniqKey="Quinn N" first="Niall" last="Quinn">Niall Quinn</name>
<affiliation wicri:level="2"><country>Royaume-Uni</country>
<placeName><region type="country">Angleterre</region>
</placeName>
<wicri:cityArea>MRC Movement Disorders Research Group, University Department of Neurology, and Parkinson's Disease Society Research Centre, Institute of Psychiatry and King's College Hospital Medical School, London</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Critchley, Peter" sort="Critchley, Peter" uniqKey="Critchley P" first="Peter" last="Critchley">Peter Critchley</name>
<affiliation wicri:level="2"><country>Royaume-Uni</country>
<placeName><region type="country">Angleterre</region>
</placeName>
<wicri:cityArea>MRC Movement Disorders Research Group, University Department of Neurology, and Parkinson's Disease Society Research Centre, Institute of Psychiatry and King's College Hospital Medical School, London</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Marsden" sort="Marsden" uniqKey="Marsden" last="Marsden">Marsden</name>
<affiliation wicri:level="2"><country>Royaume-Uni</country>
<placeName><region type="country">Angleterre</region>
</placeName>
<wicri:cityArea>MRC Movement Disorders Research Group, University Department of Neurology, and Parkinson's Disease Society Research Centre, Institute of Psychiatry and King's College Hospital Medical School, London</wicri:cityArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="1987">1987</date>
<biblScope unit="vol">2</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="73">73</biblScope>
<biblScope unit="page" to="91">91</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">9D4D1B28D9C8AFA8EB9C065678BD6C0B71299D49</idno>
<idno type="DOI">10.1002/mds.870020201</idno>
<idno type="ArticleID">MDS870020201</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Age Factors</term>
<term>Circadian Rhythm</term>
<term>Dementia (etiology)</term>
<term>Dyskinesia, Drug-Induced (etiology)</term>
<term>Dyskinesias</term>
<term>Humans</term>
<term>Juvenile</term>
<term>Levodopa (adverse effects)</term>
<term>Levodopa (therapeutic use)</term>
<term>Levodopa therapy</term>
<term>Middle Aged</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson's disease</term>
<term>Pedigree</term>
<term>Response fluctuations</term>
<term>Risk Factors</term>
<term>Tremor (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Levodopa</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dementia</term>
<term>Dyskinesia, Drug-Induced</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term>
<term>Tremor</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Levodopa</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Age Factors</term>
<term>Circadian Rhythm</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Pedigree</term>
<term>Risk Factors</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We describe a personal series of 60 cases of parkinsonism with onset under the age of 40 years. Known causes for early onset of secondary parkinsonism, such as Wilson's disease or encephalitis, were excluded in every case. Two groups were identified: those with onset after the age of 21 in whom no hereditary factors could be ascertained (56 cases), and those with onset before 21 years all of whom had familial parkinsonism. In neither group have we found any association with prematurely grey hair, hypertension, diabetes, pernicious anaemia, or thyroid disorder. Among their families, we have not found any association with diabetes, pernicious anaemia, or thyroid disorder. We propose that cases of apparent idiopathic Parkinson's disease begining between age 21–40 years should be called “young onset Parkinson's disease.” Twenty percent of such patients in our series had at least one first‐ or second‐degree relative in the same or antecedent generations with parkinsonism, but only 1.5% of their relatives at risk had parkinsonism, which is similar to the prevalence in the general population. Ten percent of these patients had at least one relative with essential tremor, but only 1.6% of their relatives at risk had tremor, which again was similar to the prevalence in the population in general. These patients with young onset Parkinson's disease responded well to levodopa therapy. However, dyskinesias and response fluctuations occurred early and frequently. The prevalence of dyskinesias and response fluctuations was strongly correlated with the duration of levodopa treatment, but not with the duration (or probably the severity) of the disease before levodopa therapy was commenced. The involuntary movements often were severe and frequently were diphasic. Despite long disease duration, the incidence of dementia in young onset patients aged less than 65 years was negligible. We believe that most, if not all, patients in this group have degenerative Lewy body idiopathic Parkinson's disease, representing the lower end of a skewed deviation for age of onset of this disease. We have so far failed to identify any additional environmental factor which may have accelerated disease onset in these patients. In contrast, cases of parkinsonism beginning before age 21 years were invariably familial. We proposed that they should be called “juvenile parkinsonism.” All affected relatives with parkinsonism also had young disease onset, and all but one were siblings. None of four such patients seen by us has demented, and computed tomography (CT) scan has been normal in all four. We believe that most such patients have some form of genetically determined secondary parkinsonism.</div>
</front>
</TEI>
</ISTEX>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006594 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 006594 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Curation |type= RBID |clé= ISTEX:9D4D1B28D9C8AFA8EB9C065678BD6C0B71299D49 |texte= Young onset Parkinson's disease }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |