Movement Disorders (revue)

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Rett syndrome and associated movement disorders

Identifieur interne : 006276 ( Main/Curation ); précédent : 006275; suivant : 006277

Rett syndrome and associated movement disorders

Auteurs : Patricia M. Fitzgerald [États-Unis] ; Jankovic [États-Unis] ; Alan K. Percy [États-Unis]

Source :

RBID : ISTEX:0543E5C43B9E3B4B8134B9F22FDECA0089EFBCA9

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English descriptors

Abstract

Rett syndrome, a progressive neurodegenerative disorder described only in female subjects, is manifested by a wide spectrum of behavioral and motor abnormalities. We studied 32 patients with this disorder, ages 30 months to 28 years old, and characterized their extrapyramidal disturbance. The most common motor abnormalities were stereotyped movements and gait disturbance, seen in all patients. Bruxism, oculogyric crises, parkinsonism, and dystonia were also common, but myoclonus and choreoathetosis were seen only infrequently. The hyperkinetic movement disorders tended to dominate in younger patients, while bradykinetic disorders were more evident in the older patients. This study provides evidence that movement disorders seen in Rett syndrome reflect age‐related neurodegenerative changes in the basal ganglia.

Url:
DOI: 10.1002/mds.870050303

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ISTEX:0543E5C43B9E3B4B8134B9F22FDECA0089EFBCA9

Le document en format XML

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