MovDisordV3, Main, Curation, bibRecord, 004E93

Ten years' experience with enteral levodopa infusions for motor fluctuations in Parkinson's disease

Identifieur interne : 004E93 ( Main/Curation ); précédent : 004E92; suivant : 004E94

Ten years' experience with enteral levodopa infusions for motor fluctuations in Parkinson's disease

Auteurs : Nadir Syed [États-Unis] ; John Murphy [États-Unis] ; Thomas Zimmerman Jr. [États-Unis] ; Margery H. Mark [États-Unis] ; Jacob I. Sage [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 1998-03.

RBID : ISTEX:54E3E3ED73F72BBA40CAD37A2EEF4D14317CA23B

Descripteurs français

Pascal (Inist)
- Adulte, Antiparkinsonien, Chimiothérapie, Dyskinésie, Fluctuation motrice, Indication, Long terme, Lévodopa, Parkinson maladie, Pompe, Traitement, Voie administration, Voie entérale.
Wicri :
- topic : Adulte, Pompe.

English descriptors

KwdEn :
- Administration, Oral, Adult, Aged, Aged, 80 and over, Antiparkinson Agents (administration & dosage), Antiparkinson agent, Chemotherapy, Dyskinesia, Dyskinesia, Drug-Induced (drug therapy), Enteral administration, Female, Fluctuations, Humans, Indication, Infusion, Infusion Pumps, Infusions, Parenteral (instrumentation), Levodopa, Levodopa (administration & dosage), Levodopa (adverse effects), Long term, Male, Middle Aged, Motor Skills (drug effects), Neurologic Examination (drug effects), Parkinson Disease (drug therapy), Parkinson disease, Parkinson's disease, Pump, Route of administration, Treatment, Treatment Outcome.
MESH :
- chemical , administration & dosage : Antiparkinson Agents, Levodopa.
- chemical , adverse effects : Levodopa.
- drug effects : Motor Skills, Neurologic Examination.
- drug therapy : Dyskinesia, Drug-Induced, Parkinson Disease.
- instrumentation : Infusions, Parenteral.
- Administration, Oral, Adult, Aged, Aged, 80 and over, Female, Humans, Infusion Pumps, Male, Middle Aged, Treatment Outcome.

Abstract

We report our long‐term experience using enteral levodopa infusions in 22 patients with Parkinson's disease and severe motor fluctuations. Amelioration of intractable dyskinesias was the most important factor that determined whether patients chose to continue using the infusion pump system. Mechanical and physical problems associated with enteral access were the most common reasons for which patients discontinued pump use. Nearly all patients continued to have dramatically increased on time for the duration of follow up, suggesting that technically less‐cumbersome systems that provide continuous dopaminergic stimulation are worthwhile and should be developed.

Url:

https://api.istex.fr/document/54E3E3ED73F72BBA40CAD37A2EEF4D14317CA23B/fulltext/pdf

DOI: 10.1002/mds.870130222

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ISTEX:54E3E3ED73F72BBA40CAD37A2EEF4D14317CA23B

Le document en format XML

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<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Ten years' experience with enteral levodopa infusions for motor fluctuations in Parkinson's disease</title>
<author><name sortKey="Syed, Nadir" sort="Syed, Nadir" uniqKey="Syed N" first="Nadir" last="Syed">Nadir Syed</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Murphy, John" sort="Murphy, John" uniqKey="Murphy J" first="John" last="Murphy">John Murphy</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Associated Neurologists, Danbury, Connecticut</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zimmerman Jr, Thomas" sort="Zimmerman Jr, Thomas" uniqKey="Zimmerman Jr T" first="Thomas" last="Zimmerman Jr.">Thomas Zimmerman Jr.</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mark, Margery H" sort="Mark, Margery H" uniqKey="Mark M" first="Margery H." last="Mark">Margery H. Mark</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sage, Jacob I" sort="Sage, Jacob I" uniqKey="Sage J" first="Jacob I." last="Sage">Jacob I. Sage</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick</wicri:cityArea>
</affiliation>
</author>
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<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="1998-03">1998-03</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antiparkinson Agents (administration & dosage)</term>
<term>Dyskinesia</term>
<term>Dyskinesia, Drug-Induced (drug therapy)</term>
<term>Female</term>
<term>Fluctuations</term>
<term>Humans</term>
<term>Infusion</term>
<term>Infusion Pumps</term>
<term>Infusions, Parenteral (instrumentation)</term>
<term>Levodopa</term>
<term>Levodopa (administration & dosage)</term>
<term>Levodopa (adverse effects)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Skills (drug effects)</term>
<term>Neurologic Examination (drug effects)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson's disease</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Levodopa</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Motor Skills</term>
<term>Neurologic Examination</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dyskinesia, Drug-Induced</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Infusions, Parenteral</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Humans</term>
<term>Infusion Pumps</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Treatment Outcome</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We report our long‐term experience using enteral levodopa infusions in 22 patients with Parkinson's disease and severe motor fluctuations. Amelioration of intractable dyskinesias was the most important factor that determined whether patients chose to continue using the infusion pump system. Mechanical and physical problems associated with enteral access were the most common reasons for which patients discontinued pump use. Nearly all patients continued to have dramatically increased on time for the duration of follow up, suggesting that technically less‐cumbersome systems that provide continuous dopaminergic stimulation are worthwhile and should be developed.</div>
</front>
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</ISTEX>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Ten years' experience with enteral levodopa infusions for motor fluctuations in Parkinson's disease

Ten years' experience with enteral levodopa infusions for motor fluctuations in Parkinson's disease

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