The Subthalamic Nucleus and Tremor in Parkinson's Disease
Identifieur interne : 004E90 ( Main/Curation ); précédent : 004E89; suivant : 004E91The Subthalamic Nucleus and Tremor in Parkinson's Disease
Auteurs : M. C. Rodriguez [Espagne] ; Oroz J. Guridi [Espagne] ; L. Alvarez [Cuba] ; K. Mewes [Cuba] ; R. Macias [Cuba] ; J. Vitek [États-Unis] ; M. R. Delong [États-Unis] ; J. A. Obeso [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 1998.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adult, Aged, Bilateral, Comparative study, Deep‐brain stimulation, Electric Stimulation (methods), Electrical stimulus, Electrocoagulation, Female, Human, Humans, Long term, Male, Middle Aged, Monitoring, Intraoperative, Parkinson Disease (complications), Parkinson disease, Parkinsonian tremor, Pathogenesis, Postoperative Period, Preoperative Care, Prognosis, Subthalamic nucleus, Subthalamotomy, Thalamic Nuclei (surgery), Treatment, Tremor, Tremor (etiology), Tremor (therapy), Unilateral.
- MESH :
- complications : Parkinson Disease.
- etiology : Tremor.
- methods : Electric Stimulation.
- surgery : Thalamic Nuclei.
- therapy : Tremor.
- Adult, Aged, Female, Humans, Male, Middle Aged, Monitoring, Intraoperative, Postoperative Period, Preoperative Care.
Abstract
The role of the subthalamic nucleus (STN) in the origin of parkinsonian tremor is discussed. Previous studies in monkeys made parkinsonian by MPTP (1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine) administration suggested a direct participation of the STN in the pathophysiology of tremor. We recorded tremor‐related activity in the STN in 12 patients with Parkinson's disease (PD) and found that microstimulation of the sensorimotor region of the nucleus, where these neurons are present, stopped the tremor with a very short latency. Long‐term treatment by means of bilateral deep‐brain stimulation (DBS) in the same 12 patients led to a significant reduction of tremor as well as other cardinal features of PD. This effect was blindly assessed at 3 months after implantation. In another group of seven patients, a unilateral lesion of the STN was performed. Both postural and resting tremor were significantly improved on the limbs contralateral to the lesion side. In three patients, tremor disappeared completely after 12 months of follow up. The electrophysiologic data and therapeutic effect of inactivating the STN strongly indicated that this structure is directly involved in the origin of parkinsonian tremor, as suggested by the MPTP model.
Url:
DOI: 10.1002/mds.870131320
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<front><div type="abstract" xml:lang="en">The role of the subthalamic nucleus (STN) in the origin of parkinsonian tremor is discussed. Previous studies in monkeys made parkinsonian by MPTP (1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine) administration suggested a direct participation of the STN in the pathophysiology of tremor. We recorded tremor‐related activity in the STN in 12 patients with Parkinson's disease (PD) and found that microstimulation of the sensorimotor region of the nucleus, where these neurons are present, stopped the tremor with a very short latency. Long‐term treatment by means of bilateral deep‐brain stimulation (DBS) in the same 12 patients led to a significant reduction of tremor as well as other cardinal features of PD. This effect was blindly assessed at 3 months after implantation. In another group of seven patients, a unilateral lesion of the STN was performed. Both postural and resting tremor were significantly improved on the limbs contralateral to the lesion side. In three patients, tremor disappeared completely after 12 months of follow up. The electrophysiologic data and therapeutic effect of inactivating the STN strongly indicated that this structure is directly involved in the origin of parkinsonian tremor, as suggested by the MPTP model.</div>
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