Irregular jerky tremor, myoclonus, and thalamus: A study using low‐frequency stimulation
Identifieur interne : 004A46 ( Main/Curation ); précédent : 004A45; suivant : 004A47Irregular jerky tremor, myoclonus, and thalamus: A study using low‐frequency stimulation
Auteurs : Boulos Paul Bejjani ; Isabelle Arnulf ; Marie Vidailhet ; Bernard Pidoux [France] ; Philippe Damier ; Savvas Papadopoulos ; Anne-Marie Bonnet ; Philippe Cornu ; Didier Dormont ; Yves Agid [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2000-09.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Adulte.
English descriptors
- KwdEn :
- Adult, Aged, Arm, Electric Stimulation (adverse effects), Electrical stimulus, Electrodes, Implanted, Essential, Functional Laterality, Humans, Instrumentation therapy, Low frequency, Middle Aged, Myoclonus, Myoclonus (etiology), Myoclonus (physiopathology), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Parkinson disease, Parkinson's disease, Stimulation, Technique, Thalamus, Thalamus (physiopathology), Thalamus (surgery), Tremor, Tremor (etiology), Tremor (physiopathology), Unilateral, Ventral Thalamic Nuclei (physiopathology).
- MESH :
- adverse effects : Electric Stimulation.
- etiology : Myoclonus, Tremor.
- physiopathology : Myoclonus, Parkinson Disease, Thalamus, Tremor, Ventral Thalamic Nuclei.
- surgery : Thalamus.
- therapy : Parkinson Disease.
- Aged, Arm, Electrodes, Implanted, Functional Laterality, Humans, Middle Aged.
Abstract
High‐frequency thalamic stimulation alleviates tremor in Parkinson's disease (PD) and essential tremor (ET). The origin of thalamic myoclonus is unexplained and the effects of low‐frequency thalamic stimulation on movement control are still unknown. We studied the effects of stimulation at a low frequency of 15 Hz in five drug‐free patients (3 PD, 2 ET) 6 months after thalamic implantation of quadripolar electrodes (unilateral in four patients, bilateral in one patient). Clinical, electrophysiological, and videotaped assessment, using a monopolar 15 Hz frequency (3 V, 90 μs) stimulation current applied simultaneously through two adjacent contacts of the electrode, was performed. We observed myoclonus and irregular jerky tremor in the upper limb contralateral to the site of stimulation. The jerks lasted less than 200 ms, were irregular and not synchronous with stimulation, were superimposed on rest or postural tremor, and increased in response to tactile, proprioceptive, or vibratory stimuli. The fact that this complex movement disorder can be induced by low‐frequency stimulation in the ventral intermediate nucleus (Vim) of the thalamus suggests that it results, at least partly, from dysfunction of the Vim and possibly adjacent nuclei of the thalamus.
Url:
DOI: 10.1002/1531-8257(200009)15:5<919::AID-MDS1024>3.0.CO;2-0
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<term>Electrical stimulus</term>
<term>Electrodes, Implanted</term>
<term>Essential</term>
<term>Functional Laterality</term>
<term>Humans</term>
<term>Instrumentation therapy</term>
<term>Low frequency</term>
<term>Middle Aged</term>
<term>Myoclonus</term>
<term>Myoclonus (etiology)</term>
<term>Myoclonus (physiopathology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Stimulation</term>
<term>Technique</term>
<term>Thalamus</term>
<term>Thalamus (physiopathology)</term>
<term>Thalamus (surgery)</term>
<term>Tremor</term>
<term>Tremor (etiology)</term>
<term>Tremor (physiopathology)</term>
<term>Unilateral</term>
<term>Ventral Thalamic Nuclei (physiopathology)</term>
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<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Electric Stimulation</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Myoclonus</term>
<term>Tremor</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Myoclonus</term>
<term>Parkinson Disease</term>
<term>Thalamus</term>
<term>Tremor</term>
<term>Ventral Thalamic Nuclei</term>
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<front><div type="abstract" xml:lang="en">High‐frequency thalamic stimulation alleviates tremor in Parkinson's disease (PD) and essential tremor (ET). The origin of thalamic myoclonus is unexplained and the effects of low‐frequency thalamic stimulation on movement control are still unknown. We studied the effects of stimulation at a low frequency of 15 Hz in five drug‐free patients (3 PD, 2 ET) 6 months after thalamic implantation of quadripolar electrodes (unilateral in four patients, bilateral in one patient). Clinical, electrophysiological, and videotaped assessment, using a monopolar 15 Hz frequency (3 V, 90 μs) stimulation current applied simultaneously through two adjacent contacts of the electrode, was performed. We observed myoclonus and irregular jerky tremor in the upper limb contralateral to the site of stimulation. The jerks lasted less than 200 ms, were irregular and not synchronous with stimulation, were superimposed on rest or postural tremor, and increased in response to tactile, proprioceptive, or vibratory stimuli. The fact that this complex movement disorder can be induced by low‐frequency stimulation in the ventral intermediate nucleus (Vim) of the thalamus suggests that it results, at least partly, from dysfunction of the Vim and possibly adjacent nuclei of the thalamus.</div>
</front>
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<front><div type="abstract" xml:lang="en">High‐frequency thalamic stimulation alleviates tremor in Parkinson's disease (PD) and essential tremor (ET). The origin of thalamic myoclonus is unexplained and the effects of low‐frequency thalamic stimulation on movement control are still unknown. We studied the effects of stimulation at a low frequency of 15 Hz in five drug‐free patients (3 PD, 2 ET) 6 months after thalamic implantation of quadripolar electrodes (unilateral in four patients, bilateral in one patient). Clinical, electrophysiological, and videotaped assessment, using a monopolar 15 Hz frequency (3 V, 90 μs) stimulation current applied simultaneously through two adjacent contacts of the electrode, was performed. We observed myoclonus and irregular jerky tremor in the upper limb contralateral to the site of stimulation. The jerks lasted less than 200 ms, were irregular and not synchronous with stimulation, were superimposed on rest or postural tremor, and increased in response to tactile, proprioceptive, or vibratory stimuli. The fact that this complex movement disorder can be induced by low‐frequency stimulation in the ventral intermediate nucleus (Vim) of the thalamus suggests that it results, at least partly, from dysfunction of the Vim and possibly adjacent nuclei of the thalamus.</div>
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<idno type="wicri:doubleKey">0885-3185:2000:Bejjani B:irregular:jerky:tremor</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Irregular jerky tremor, myoclonus, and thalamus: a study using low-frequency stimulation.</title>
<author><name sortKey="Bejjani, B P" sort="Bejjani, B P" uniqKey="Bejjani B" first="B P" last="Bejjani">B P Bejjani</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre d'Investigation Clinique--Inserm U289, Fédération de Neurologíe, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre d'Investigation Clinique--Inserm U289, Fédération de Neurologíe, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Arnulf, I" sort="Arnulf, I" uniqKey="Arnulf I" first="I" last="Arnulf">I. Arnulf</name>
</author>
<author><name sortKey="Vidailhet, M" sort="Vidailhet, M" uniqKey="Vidailhet M" first="M" last="Vidailhet">M. Vidailhet</name>
</author>
<author><name sortKey="Pidoux, B" sort="Pidoux, B" uniqKey="Pidoux B" first="B" last="Pidoux">B. Pidoux</name>
</author>
<author><name sortKey="Damier, P" sort="Damier, P" uniqKey="Damier P" first="P" last="Damier">P. Damier</name>
</author>
<author><name sortKey="Papadopoulos, S" sort="Papadopoulos, S" uniqKey="Papadopoulos S" first="S" last="Papadopoulos">S. Papadopoulos</name>
</author>
<author><name sortKey="Bonnet, A M" sort="Bonnet, A M" uniqKey="Bonnet A" first="A M" last="Bonnet">A M Bonnet</name>
</author>
<author><name sortKey="Cornu, P" sort="Cornu, P" uniqKey="Cornu P" first="P" last="Cornu">P. Cornu</name>
</author>
<author><name sortKey="Dormont, D" sort="Dormont, D" uniqKey="Dormont D" first="D" last="Dormont">D. Dormont</name>
</author>
<author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Yves Agid</name>
<affiliation><country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2000" type="published">2000</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Arm</term>
<term>Electric Stimulation (adverse effects)</term>
<term>Electrodes, Implanted</term>
<term>Functional Laterality</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Myoclonus (etiology)</term>
<term>Myoclonus (physiopathology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Thalamus (physiopathology)</term>
<term>Thalamus (surgery)</term>
<term>Tremor (etiology)</term>
<term>Tremor (physiopathology)</term>
<term>Ventral Thalamic Nuclei (physiopathology)</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Electric Stimulation</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Myoclonus</term>
<term>Tremor</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Myoclonus</term>
<term>Parkinson Disease</term>
<term>Thalamus</term>
<term>Tremor</term>
<term>Ventral Thalamic Nuclei</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Thalamus</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Arm</term>
<term>Electrodes, Implanted</term>
<term>Functional Laterality</term>
<term>Humans</term>
<term>Middle Aged</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">High-frequency thalamic stimulation alleviates tremor in Parkinson's disease (PD) and essential tremor (ET). The origin of thalamic myoclonus is unexplained and the effects of low-frequency thalamic stimulation on movement control are still unknown. We studied the effects of stimulation at a low frequency of 15 Hz in five drug-free patients (3 PD, 2 ET) 6 months after thalamic implantation of quadripolar electrodes (unilateral in four patients, bilateral in one patient). Clinical, electrophysiological, and videotaped assessment, using a monopolar 15 Hz frequency (3 V, 90 micros) stimulation current applied simultaneously through two adjacent contacts of the electrode, was performed. We observed myoclonus and irregular jerky tremor in the upper limb contralateral to the site of stimulation. The jerks lasted less than 200 ms, were irregular and not synchronous with stimulation, were superimposed on rest or postural tremor, and increased in response to tactile, proprioceptive, or vibratory stimuli. The fact that this complex movement disorder can be induced by low-frequency stimulation in the ventral intermediate nucleus (Vim) of the thalamus suggests that it results, at least partly, from dysfunction of the Vim and possibly adjacent nuclei of the thalamus.</div>
</front>
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