Risk of incident dementia in essential tremor : A population-based study
Identifieur interne : 003075 ( Main/Curation ); précédent : 003074; suivant : 003076Risk of incident dementia in essential tremor : A population-based study
Auteurs : Félix Bermejo-Pareja [Espagne] ; Elan D. Louis [États-Unis] ; Julian Benito-Leon [Espagne]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
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Abstract
Essential tremor (ET) is a late-life neurological disease. Mild cognitive deficits as well as an association with prevalent dementia have been reported in recent case-control studies. We determined whether ET was associated with an increased risk of incident dementia. In a population-based study of older people in central Spain (NEDICES), nondemented ET cases and controls were followed prospectively. Incident dementia at follow-up was diagnosed using DSM-IV criteria and the risk of incident dementia was estimated in ET cases versus controls using Cox proportional hazards models. 3,891 participants had a mean duration of follow-up of 3.2 years. Sixteen (7.8%) of 206 ET cases developed incident dementia versus 145 (3.9%) of 3,685 controls (unadjusted relative risk [RR] = 2.08, 95% CI = 1.24-3.50, P = 0.006 and adjusted RR = 1.66, 95% CI = 0.99-2.80, P = 0.054). In an adjusted model, ET cases with tremor onset after age 65 years were twice as likely to develop incident dementia than were controls (RR = 1.98, 95% CI = 1.14-3.45, P = 0.01), whereas ET cases with tremor onset < age 65 years and controls were equally to develop incident dementia (RR = 0.74, 95% CI = 0.19-3.20, P = 0.79). Although ET is often considered a benign condition, in this prospective, population-based study, elderly-onset ET was associated with an increased risk of incident dementia. The basis for this dementia, which is not known, requires additional study.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Risk of incident dementia in essential tremor : A population-based study</title><author><name sortKey="Bermejo Pareja, Felix" sort="Bermejo Pareja, Felix" uniqKey="Bermejo Pareja F" first="Félix" last="Bermejo-Pareja">Félix Bermejo-Pareja</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital "12 de Octubre</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>G.H. Sergievsky Center and Department of Neurology, College of Physicians and Surgeons, Columbia University</s1><s2>New York</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Benito Leon, Julian" sort="Benito Leon, Julian" uniqKey="Benito Leon J" first="Julian" last="Benito-Leon">Julian Benito-Leon</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital "12 de Octubre</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">07-0448792</idno><date when="2007">2007</date><idno type="stanalyst">PASCAL 07-0448792 INIST</idno><idno type="RBID">Pascal:07-0448792</idno><idno type="wicri:Area/PascalFrancis/Corpus">001568</idno><idno type="wicri:Area/PascalFrancis/Curation">001753</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001480</idno><idno type="wicri:doubleKey">0885-3185:2007:Bermejo Pareja F:risk:of:incident</idno><idno type="wicri:Area/Main/Merge">004070</idno><idno type="wicri:Area/Main/Curation">003075</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Risk of incident dementia in essential tremor : A population-based study</title><author><name sortKey="Bermejo Pareja, Felix" sort="Bermejo Pareja, Felix" uniqKey="Bermejo Pareja F" first="Félix" last="Bermejo-Pareja">Félix Bermejo-Pareja</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital "12 de Octubre</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>G.H. Sergievsky Center and Department of Neurology, College of Physicians and Surgeons, Columbia University</s1><s2>New York</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Benito Leon, Julian" sort="Benito Leon, Julian" uniqKey="Benito Leon J" first="Julian" last="Benito-Leon">Julian Benito-Leon</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital "12 de Octubre</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dementia</term><term>Epidemiology</term><term>Nervous system diseases</term><term>Risk factor</term><term>Tremor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Démence</term><term>Tremblement</term><term>Facteur risque</term><term>Epidémiologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Essential tremor (ET) is a late-life neurological disease. Mild cognitive deficits as well as an association with prevalent dementia have been reported in recent case-control studies. We determined whether ET was associated with an increased risk of incident dementia. In a population-based study of older people in central Spain (NEDICES), nondemented ET cases and controls were followed prospectively. Incident dementia at follow-up was diagnosed using DSM-IV criteria and the risk of incident dementia was estimated in ET cases versus controls using Cox proportional hazards models. 3,891 participants had a mean duration of follow-up of 3.2 years. Sixteen (7.8%) of 206 ET cases developed incident dementia versus 145 (3.9%) of 3,685 controls (unadjusted relative risk [RR] = 2.08, 95% CI = 1.24-3.50, P = 0.006 and adjusted RR = 1.66, 95% CI = 0.99-2.80, P = 0.054). In an adjusted model, ET cases with tremor onset after age 65 years were twice as likely to develop incident dementia than were controls (RR = 1.98, 95% CI = 1.14-3.45, P = 0.01), whereas ET cases with tremor onset < age 65 years and controls were equally to develop incident dementia (RR = 0.74, 95% CI = 0.19-3.20, P = 0.79). Although ET is often considered a benign condition, in this prospective, population-based study, elderly-onset ET was associated with an increased risk of incident dementia. The basis for this dementia, which is not known, requires additional study.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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