MovDisordV3, Main, Curation, bibRecord, 002998

Apparent diffusion coefficient of the superior cerebellar peduncle differentiates progressive supranuclear palsy from Parkinson's disease

Identifieur interne : 002998 ( Main/Curation ); précédent : 002997; suivant : 002999

Apparent diffusion coefficient of the superior cerebellar peduncle differentiates progressive supranuclear palsy from Parkinson's disease

Auteurs : Giuseppe Nicoletti [Italie] ; Caterina Tonon [Italie] ; Raffaele Lodi [Italie] ; Francesca Condino [Italie] ; David Manners [Italie] ; Emil Malucelli [Italie] ; Maurizio Morelli [Italie] ; Fabiana Novellino [Italie] ; Sandra Paglionico [Italie] ; Pierluigi Lanza [Italie] ; Demetrio Messina [Italie] ; Paolo Barone [Italie] ; Letterio Morgante [Italie] ; Mario Zappia [Italie] ; Bruno Barbiroli [Italie] ; Aldo Quattrone [Italie]

Source :

Movement Disorders [ 0885-3185 ] ; 2008-12-15.

RBID : ISTEX:B7F9CB6F8450FDFEE0DF2BF7EC8D30A017F93B38

Descripteurs français

Pascal (Inist)
- Atrophie multisystématisée, Coefficient diffusion, Maladie de Parkinson, Pathologie du système nerveux, Pédoncule cérébelleux.

English descriptors

KwdEn :
- Aged, Cerebellar peduncle, Cerebellum (pathology), Chi-Square Distribution, DWI, Diagnosis, Differential, Diffusion Magnetic Resonance Imaging, Diffusion coefficient, Female, Humans, Male, Middle Aged, Multiple system atrophy, Nervous system diseases, Parkinson Disease (diagnosis), Parkinson disease, Parkinson's disease, Sensitivity and Specificity, Supranuclear Palsy, Progressive (diagnosis), multiple system atrophy, neurodegenerative disorders, progressive supranuclear palsy, superior cerebellar peduncle.
MESH :
- diagnosis : Parkinson Disease, Supranuclear Palsy, Progressive.
- pathology : Cerebellum.
- Aged, Chi-Square Distribution, Diagnosis, Differential, Diffusion Magnetic Resonance Imaging, Female, Humans, Male, Middle Aged, Sensitivity and Specificity.

Abstract

The early diagnosis of progressive supranuclear palsy (PSP) may be challenging, because of clinical overlapping features with Parkinson's disease (PD) and other parkinsonian syndromes such as the Parkinsonian variant of multiple system atrophy (MSA‐P). Conventional MRI can help in differentiating parkinsonian disorders but its diagnostic accuracy is still unsatisfactory. On the basis of the pathological demonstration of superior cerebellar peduncle (SCP) atrophy in patients with PSP, we assessed the SCP apparent diffusion coefficient (ADC) values in patients with PSP, PD, and MSA‐P in order to evaluate its differential diagnostic value in vivo. Twenty‐eight patients with PSP (14 with possible‐PSP and 14 with probable‐PSP), 15 PD, 15 MSA‐P, and 16 healthy subjects were studied by using diffusion weighted imaging (DWI). ADC was calculated in regions of interest defined in the left and right SCP by two clinically blinded operators. Intrarater (r = 0.98, P < 0.001) and interrater reliability (r = 0.97; P < 0.001) for SCP measurements were high. Patients with PSP had higher SCP rADC values (median 0.98 × 10−3mm2/s) than patients with PD (median 0.79 × 10−3 mm2/s, P < 0.001), MSA‐P (median 0.79 × 10−3 mm2/s, P < 0.001), and healthy controls (median 0.80 × 10−3 mm2/s, P < 0.001). DWI discriminated patients with PSP from PD and healthy subjects on the basis of SCP rADC individual values (100% sensitivity and specificity) and from patients with MSA‐P (96.4% sensitivity and 93.3% specificity). The higher values of rADC in SCP of patients with PSP correspond with the in vivo microstructural feature of atrophy detected postmortem and provide an additional support for early discrimination between PSP and other neurodegenerative parkinsonisms. © 2008 Movement Disorder Society

Url:

https://api.istex.fr/document/B7F9CB6F8450FDFEE0DF2BF7EC8D30A017F93B38/fulltext/pdf

DOI: 10.1002/mds.22279

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Cerebellar peduncle</term>
<term>Cerebellum (pathology)</term>
<term>Chi-Square Distribution</term>
<term>DWI</term>
<term>Diagnosis, Differential</term>
<term>Diffusion Magnetic Resonance Imaging</term>
<term>Diffusion coefficient</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multiple system atrophy</term>
<term>Nervous system diseases</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Sensitivity and Specificity</term>
<term>Supranuclear Palsy, Progressive (diagnosis)</term>
<term>multiple system atrophy</term>
<term>neurodegenerative disorders</term>
<term>progressive supranuclear palsy</term>
<term>superior cerebellar peduncle</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term>
<term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cerebellum</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Chi-Square Distribution</term>
<term>Diagnosis, Differential</term>
<term>Diffusion Magnetic Resonance Imaging</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Sensitivity and Specificity</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Atrophie multisystématisée</term>
<term>Coefficient diffusion</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Pédoncule cérébelleux</term>
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<front><div type="abstract" xml:lang="en">The early diagnosis of progressive supranuclear palsy (PSP) may be challenging, because of clinical overlapping features with Parkinson's disease (PD) and other parkinsonian syndromes such as the Parkinsonian variant of multiple system atrophy (MSA‐P). Conventional MRI can help in differentiating parkinsonian disorders but its diagnostic accuracy is still unsatisfactory. On the basis of the pathological demonstration of superior cerebellar peduncle (SCP) atrophy in patients with PSP, we assessed the SCP apparent diffusion coefficient (ADC) values in patients with PSP, PD, and MSA‐P in order to evaluate its differential diagnostic value in vivo. Twenty‐eight patients with PSP (14 with possible‐PSP and 14 with probable‐PSP), 15 PD, 15 MSA‐P, and 16 healthy subjects were studied by using diffusion weighted imaging (DWI). ADC was calculated in regions of interest defined in the left and right SCP by two clinically blinded operators. Intrarater (r = 0.98, P < 0.001) and interrater reliability (r = 0.97; P < 0.001) for SCP measurements were high. Patients with PSP had higher SCP rADC values (median 0.98 × 10−3mm2/s) than patients with PD (median 0.79 × 10−3 mm2/s, P < 0.001), MSA‐P (median 0.79 × 10−3 mm2/s, P < 0.001), and healthy controls (median 0.80 × 10−3 mm2/s, P < 0.001). DWI discriminated patients with PSP from PD and healthy subjects on the basis of SCP rADC individual values (100% sensitivity and specificity) and from patients with MSA‐P (96.4% sensitivity and 93.3% specificity). The higher values of rADC in SCP of patients with PSP correspond with the in vivo microstructural feature of atrophy detected postmortem and provide an additional support for early discrimination between PSP and other neurodegenerative parkinsonisms. © 2008 Movement Disorder Society</div>
</front>
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<sZ>16 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
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<author><name sortKey="Tonon, Caterina" sort="Tonon, Caterina" uniqKey="Tonon C" first="Caterina" last="Tonon">Caterina Tonon</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Dipartimento di Medicina Clinica e Biotecnologia Applicata "D. Campanacci", Universitd di Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Italie</country>
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</affiliation>
</author>
<author><name sortKey="Lodi, Raffaele" sort="Lodi, Raffaele" uniqKey="Lodi R" first="Raffaele" last="Lodi">Raffaele Lodi</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Dipartimento di Medicina Clinica e Biotecnologia Applicata "D. Campanacci", Universitd di Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>15 aut.</sZ>
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<country>Italie</country>
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</affiliation>
</author>
<author><name sortKey="Condino, Francesca" sort="Condino, Francesca" uniqKey="Condino F" first="Francesca" last="Condino">Francesca Condino</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone</s1>
<s2>Cosenza</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Cosenza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Manners, David" sort="Manners, David" uniqKey="Manners D" first="David" last="Manners">David Manners</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Dipartimento di Medicina Clinica e Biotecnologia Applicata "D. Campanacci", Universitd di Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Italie</country>
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</affiliation>
</author>
<author><name sortKey="Malucelli, Emil" sort="Malucelli, Emil" uniqKey="Malucelli E" first="Emil" last="Malucelli">Emil Malucelli</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Dipartimento di Medicina Clinica e Biotecnologia Applicata "D. Campanacci", Universitd di Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morelli, Maurizio" sort="Morelli, Maurizio" uniqKey="Morelli M" first="Maurizio" last="Morelli">Maurizio Morelli</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Neurology, Department of Medical Sciences, University Magna Graecia</s1>
<s2>Catanzaro</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Novellino, Fabiana" sort="Novellino, Fabiana" uniqKey="Novellino F" first="Fabiana" last="Novellino">Fabiana Novellino</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Neurology, Department of Medical Sciences, University Magna Graecia</s1>
<s2>Catanzaro</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Paglionico, Sandra" sort="Paglionico, Sandra" uniqKey="Paglionico S" first="Sandra" last="Paglionico">Sandra Paglionico</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Neurology, Department of Medical Sciences, University Magna Graecia</s1>
<s2>Catanzaro</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lanza, Pierluigi" sort="Lanza, Pierluigi" uniqKey="Lanza P" first="Pierluigi" last="Lanza">Pierluigi Lanza</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone</s1>
<s2>Cosenza</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Cosenza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Messina, Demetrio" sort="Messina, Demetrio" uniqKey="Messina D" first="Demetrio" last="Messina">Demetrio Messina</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone</s1>
<s2>Cosenza</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Cosenza</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Neurology, Department of Medical Sciences, University Magna Graecia</s1>
<s2>Catanzaro</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurological Sciences, University Federico II</s1>
<s2>Napoli</s2>
<s3>ITA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Napoli</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morgante, Letterio" sort="Morgante, Letterio" uniqKey="Morgante L" first="Letterio" last="Morgante">Letterio Morgante</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neuro science, Psychiatry and Anestesiology, Policlinico Universitario, University of Messina</s1>
<s2>Messina</s2>
<s3>ITA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Messina</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zappia, Mario" sort="Zappia, Mario" uniqKey="Zappia M" first="Mario" last="Zappia">Mario Zappia</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Dipartimento di Neuroscienze, Clinica Neurologica I, Universitd di Catania</s1>
<s2>Catania</s2>
<s3>ITA</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Catania</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Barbiroli, Bruno" sort="Barbiroli, Bruno" uniqKey="Barbiroli B" first="Bruno" last="Barbiroli">Bruno Barbiroli</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Dipartimento di Medicina Clinica e Biotecnologia Applicata "D. Campanacci", Universitd di Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone</s1>
<s2>Cosenza</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Cosenza</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Neurology, Department of Medical Sciences, University Magna Graecia</s1>
<s2>Catanzaro</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>16 aut.</sZ>
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<country>Italie</country>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">09-0058912</idno>
<date when="2008">2008</date>
<idno type="stanalyst">PASCAL 09-0058912 INIST</idno>
<idno type="RBID">Pascal:09-0058912</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001026</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001C93</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001364</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Nicoletti G:apparent:diffusion:coefficient</idno>
<idno type="wicri:Area/Main/Merge">003972</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Apparent Diffusion Coefficient of the Superior Cerebellar Peduncle Differentiates Progressive Supranuclear Palsy from Parkinson's Disease</title>
<author><name sortKey="Nicoletti, Giuseppe" sort="Nicoletti, Giuseppe" uniqKey="Nicoletti G" first="Giuseppe" last="Nicoletti">Giuseppe Nicoletti</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone</s1>
<s2>Cosenza</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Cosenza</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Neurology, Department of Medical Sciences, University Magna Graecia</s1>
<s2>Catanzaro</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tonon, Caterina" sort="Tonon, Caterina" uniqKey="Tonon C" first="Caterina" last="Tonon">Caterina Tonon</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Dipartimento di Medicina Clinica e Biotecnologia Applicata "D. Campanacci", Universitd di Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lodi, Raffaele" sort="Lodi, Raffaele" uniqKey="Lodi R" first="Raffaele" last="Lodi">Raffaele Lodi</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Dipartimento di Medicina Clinica e Biotecnologia Applicata "D. Campanacci", Universitd di Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Condino, Francesca" sort="Condino, Francesca" uniqKey="Condino F" first="Francesca" last="Condino">Francesca Condino</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone</s1>
<s2>Cosenza</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Cosenza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Manners, David" sort="Manners, David" uniqKey="Manners D" first="David" last="Manners">David Manners</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Dipartimento di Medicina Clinica e Biotecnologia Applicata "D. Campanacci", Universitd di Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Malucelli, Emil" sort="Malucelli, Emil" uniqKey="Malucelli E" first="Emil" last="Malucelli">Emil Malucelli</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Dipartimento di Medicina Clinica e Biotecnologia Applicata "D. Campanacci", Universitd di Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morelli, Maurizio" sort="Morelli, Maurizio" uniqKey="Morelli M" first="Maurizio" last="Morelli">Maurizio Morelli</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Neurology, Department of Medical Sciences, University Magna Graecia</s1>
<s2>Catanzaro</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Novellino, Fabiana" sort="Novellino, Fabiana" uniqKey="Novellino F" first="Fabiana" last="Novellino">Fabiana Novellino</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Neurology, Department of Medical Sciences, University Magna Graecia</s1>
<s2>Catanzaro</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Paglionico, Sandra" sort="Paglionico, Sandra" uniqKey="Paglionico S" first="Sandra" last="Paglionico">Sandra Paglionico</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Neurology, Department of Medical Sciences, University Magna Graecia</s1>
<s2>Catanzaro</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lanza, Pierluigi" sort="Lanza, Pierluigi" uniqKey="Lanza P" first="Pierluigi" last="Lanza">Pierluigi Lanza</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone</s1>
<s2>Cosenza</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Cosenza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Messina, Demetrio" sort="Messina, Demetrio" uniqKey="Messina D" first="Demetrio" last="Messina">Demetrio Messina</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone</s1>
<s2>Cosenza</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Cosenza</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Neurology, Department of Medical Sciences, University Magna Graecia</s1>
<s2>Catanzaro</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurological Sciences, University Federico II</s1>
<s2>Napoli</s2>
<s3>ITA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Napoli</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morgante, Letterio" sort="Morgante, Letterio" uniqKey="Morgante L" first="Letterio" last="Morgante">Letterio Morgante</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neuro science, Psychiatry and Anestesiology, Policlinico Universitario, University of Messina</s1>
<s2>Messina</s2>
<s3>ITA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Messina</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zappia, Mario" sort="Zappia, Mario" uniqKey="Zappia M" first="Mario" last="Zappia">Mario Zappia</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Dipartimento di Neuroscienze, Clinica Neurologica I, Universitd di Catania</s1>
<s2>Catania</s2>
<s3>ITA</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Catania</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Barbiroli, Bruno" sort="Barbiroli, Bruno" uniqKey="Barbiroli B" first="Bruno" last="Barbiroli">Bruno Barbiroli</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Dipartimento di Medicina Clinica e Biotecnologia Applicata "D. Campanacci", Universitd di Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone</s1>
<s2>Cosenza</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
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</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Neurology, Department of Medical Sciences, University Magna Graecia</s1>
<s2>Catanzaro</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
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<country>Italie</country>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
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</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebellar peduncle</term>
<term>Diffusion coefficient</term>
<term>Multiple system atrophy</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Atrophie multisystématisée</term>
<term>Pathologie du   système nerveux</term>
<term>Coefficient diffusion</term>
<term>Pédoncule cérébelleux</term>
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<front><div type="abstract" xml:lang="en">The early diagnosis of progressive supranuclear palsy (PSP) may be challenging, because of clinical overlapping features with Parkinson's disease (PD) and other parkinsonian syndromes such as the Parkinsonian variant of multiple system atrophy (MSA-P). Conventional MRI can help in differentiating parkinsonian disorders but its diagnostic accuracy is still unsatisfactory. On the basis of the pathological demonstration of superior cerebellar peduncle (SCP) atrophy in patients with PSP, we assessed the SCP apparent diffusion coefficient (ADC) values in patients with PSP, PD, and MSA-P in order to evaluate its differential diagnostic value in vivo. Twenty-eight patients with PSP (14 with possible-PSP and 14 with probable-PSP), 15 PD, 15 MSA-P, and 16 healthy subjects were studied by using diffusion weighted imaging (DWI). ADC was calculated in regions of interest defined in the left and right SCP by two clinically blinded operators. Intrarater (r = 0.98, P < 0.001) and interrater reliability (r = 0.97; P < 0.001) for SCP measurements were high. Patients with PSP had higher SCP rADC values (median 0.98 X 10<sup>-3</sup>
mm<sup>2</sup>
/s) than patients with PD (median 0.79 X 10<sup>-3</sup>
 mm<sup>2</sup>
/s, P < 0.001), MSA-P (median 0.79 X 10<sup>-3</sup>
 mm<sup>2</sup>
/s, P < 0.001), and healthy controls (median 0.80 X 10<sup>-3</sup>
 mm<sup>2</sup>
/s, P < 0.001). DWI discriminated patients with PSP from PD and healthy subjects on the basis of SCP rADC individual values (100% sensitivity and specificity) and from patients with MSA-P (96.4% sensitivity and 93.3% specificity). The higher values of rADC in SCP of patients with PSP correspond with the in vivo microstructural feature of atrophy detected postmortem and provide an additional support for early discrimination between PSP and other neurodegenerative parkinsonisms.</div>
</front>
</TEI>
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<ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Apparent diffusion coefficient of the superior cerebellar peduncle differentiates progressive supranuclear palsy from Parkinson's disease</title>
<author><name sortKey="Nicoletti, Giuseppe" sort="Nicoletti, Giuseppe" uniqKey="Nicoletti G" first="Giuseppe" last="Nicoletti">Giuseppe Nicoletti</name>
</author>
<author><name sortKey="Tonon, Caterina" sort="Tonon, Caterina" uniqKey="Tonon C" first="Caterina" last="Tonon">Caterina Tonon</name>
</author>
<author><name sortKey="Lodi, Raffaele" sort="Lodi, Raffaele" uniqKey="Lodi R" first="Raffaele" last="Lodi">Raffaele Lodi</name>
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<author><name sortKey="Condino, Francesca" sort="Condino, Francesca" uniqKey="Condino F" first="Francesca" last="Condino">Francesca Condino</name>
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<author><name sortKey="Manners, David" sort="Manners, David" uniqKey="Manners D" first="David" last="Manners">David Manners</name>
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<author><name sortKey="Malucelli, Emil" sort="Malucelli, Emil" uniqKey="Malucelli E" first="Emil" last="Malucelli">Emil Malucelli</name>
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<author><name sortKey="Novellino, Fabiana" sort="Novellino, Fabiana" uniqKey="Novellino F" first="Fabiana" last="Novellino">Fabiana Novellino</name>
</author>
<author><name sortKey="Paglionico, Sandra" sort="Paglionico, Sandra" uniqKey="Paglionico S" first="Sandra" last="Paglionico">Sandra Paglionico</name>
</author>
<author><name sortKey="Lanza, Pierluigi" sort="Lanza, Pierluigi" uniqKey="Lanza P" first="Pierluigi" last="Lanza">Pierluigi Lanza</name>
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<author><name sortKey="Messina, Demetrio" sort="Messina, Demetrio" uniqKey="Messina D" first="Demetrio" last="Messina">Demetrio Messina</name>
</author>
<author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name>
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<author><name sortKey="Morgante, Letterio" sort="Morgante, Letterio" uniqKey="Morgante L" first="Letterio" last="Morgante">Letterio Morgante</name>
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<author><name sortKey="Zappia, Mario" sort="Zappia, Mario" uniqKey="Zappia M" first="Mario" last="Zappia">Mario Zappia</name>
</author>
<author><name sortKey="Barbiroli, Bruno" sort="Barbiroli, Bruno" uniqKey="Barbiroli B" first="Bruno" last="Barbiroli">Bruno Barbiroli</name>
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<author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name>
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<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Apparent diffusion coefficient of the superior cerebellar peduncle differentiates progressive supranuclear palsy from Parkinson's disease</title>
<author><name sortKey="Nicoletti, Giuseppe" sort="Nicoletti, Giuseppe" uniqKey="Nicoletti G" first="Giuseppe" last="Nicoletti">Giuseppe Nicoletti</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza</wicri:regionArea>
<wicri:noRegion>Cosenza</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro</wicri:regionArea>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tonon, Caterina" sort="Tonon, Caterina" uniqKey="Tonon C" first="Caterina" last="Tonon">Caterina Tonon</name>
<affiliation wicri:level="4"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna</wicri:regionArea>
<orgName type="university">Université de Bologne</orgName>
<placeName><settlement type="city">Bologne</settlement>
<region nuts="2" type="region">Émilie-Romagne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lodi, Raffaele" sort="Lodi, Raffaele" uniqKey="Lodi R" first="Raffaele" last="Lodi">Raffaele Lodi</name>
<affiliation wicri:level="4"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna</wicri:regionArea>
<orgName type="university">Université de Bologne</orgName>
<placeName><settlement type="city">Bologne</settlement>
<region nuts="2" type="region">Émilie-Romagne</region>
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<author><name sortKey="Condino, Francesca" sort="Condino, Francesca" uniqKey="Condino F" first="Francesca" last="Condino">Francesca Condino</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza</wicri:regionArea>
<wicri:noRegion>Cosenza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Manners, David" sort="Manners, David" uniqKey="Manners D" first="David" last="Manners">David Manners</name>
<affiliation wicri:level="4"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna</wicri:regionArea>
<orgName type="university">Université de Bologne</orgName>
<placeName><settlement type="city">Bologne</settlement>
<region nuts="2" type="region">Émilie-Romagne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Malucelli, Emil" sort="Malucelli, Emil" uniqKey="Malucelli E" first="Emil" last="Malucelli">Emil Malucelli</name>
<affiliation wicri:level="4"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna</wicri:regionArea>
<orgName type="university">Université de Bologne</orgName>
<placeName><settlement type="city">Bologne</settlement>
<region nuts="2" type="region">Émilie-Romagne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morelli, Maurizio" sort="Morelli, Maurizio" uniqKey="Morelli M" first="Maurizio" last="Morelli">Maurizio Morelli</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro</wicri:regionArea>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Novellino, Fabiana" sort="Novellino, Fabiana" uniqKey="Novellino F" first="Fabiana" last="Novellino">Fabiana Novellino</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro</wicri:regionArea>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
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<author><name sortKey="Paglionico, Sandra" sort="Paglionico, Sandra" uniqKey="Paglionico S" first="Sandra" last="Paglionico">Sandra Paglionico</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro</wicri:regionArea>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lanza, Pierluigi" sort="Lanza, Pierluigi" uniqKey="Lanza P" first="Pierluigi" last="Lanza">Pierluigi Lanza</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza</wicri:regionArea>
<wicri:noRegion>Cosenza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Messina, Demetrio" sort="Messina, Demetrio" uniqKey="Messina D" first="Demetrio" last="Messina">Demetrio Messina</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza</wicri:regionArea>
<wicri:noRegion>Cosenza</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro</wicri:regionArea>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurological Sciences, University Federico II, Napoli</wicri:regionArea>
<wicri:noRegion>Napoli</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morgante, Letterio" sort="Morgante, Letterio" uniqKey="Morgante L" first="Letterio" last="Morgante">Letterio Morgante</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neuroscience, Psychiatry and Anestesiology, Policlinico Universitario, University of Messina, Messina</wicri:regionArea>
<wicri:noRegion>Messina</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zappia, Mario" sort="Zappia, Mario" uniqKey="Zappia M" first="Mario" last="Zappia">Mario Zappia</name>
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<wicri:regionArea>Dipartimento di Neuroscienze, Clinica Neurologica I, Università di Catania, Catania</wicri:regionArea>
<wicri:noRegion>Catania</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Barbiroli, Bruno" sort="Barbiroli, Bruno" uniqKey="Barbiroli B" first="Bruno" last="Barbiroli">Bruno Barbiroli</name>
<affiliation wicri:level="4"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna</wicri:regionArea>
<orgName type="university">Université de Bologne</orgName>
<placeName><settlement type="city">Bologne</settlement>
<region nuts="2" type="region">Émilie-Romagne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza</wicri:regionArea>
<wicri:noRegion>Cosenza</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro</wicri:regionArea>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
</author>
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<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2008-12-15">2008-12-15</date>
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<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">B7F9CB6F8450FDFEE0DF2BF7EC8D30A017F93B38</idno>
<idno type="DOI">10.1002/mds.22279</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Cerebellum (pathology)</term>
<term>Chi-Square Distribution</term>
<term>DWI</term>
<term>Diagnosis, Differential</term>
<term>Diffusion Magnetic Resonance Imaging</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson's disease</term>
<term>Sensitivity and Specificity</term>
<term>Supranuclear Palsy, Progressive (diagnosis)</term>
<term>multiple system atrophy</term>
<term>neurodegenerative disorders</term>
<term>progressive supranuclear palsy</term>
<term>superior cerebellar peduncle</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term>
<term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cerebellum</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Chi-Square Distribution</term>
<term>Diagnosis, Differential</term>
<term>Diffusion Magnetic Resonance Imaging</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Sensitivity and Specificity</term>
</keywords>
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<front><div type="abstract" xml:lang="en">The early diagnosis of progressive supranuclear palsy (PSP) may be challenging, because of clinical overlapping features with Parkinson's disease (PD) and other parkinsonian syndromes such as the Parkinsonian variant of multiple system atrophy (MSA‐P). Conventional MRI can help in differentiating parkinsonian disorders but its diagnostic accuracy is still unsatisfactory. On the basis of the pathological demonstration of superior cerebellar peduncle (SCP) atrophy in patients with PSP, we assessed the SCP apparent diffusion coefficient (ADC) values in patients with PSP, PD, and MSA‐P in order to evaluate its differential diagnostic value in vivo. Twenty‐eight patients with PSP (14 with possible‐PSP and 14 with probable‐PSP), 15 PD, 15 MSA‐P, and 16 healthy subjects were studied by using diffusion weighted imaging (DWI). ADC was calculated in regions of interest defined in the left and right SCP by two clinically blinded operators. Intrarater (r = 0.98, P < 0.001) and interrater reliability (r = 0.97; P < 0.001) for SCP measurements were high. Patients with PSP had higher SCP rADC values (median 0.98 × 10−3mm2/s) than patients with PD (median 0.79 × 10−3 mm2/s, P < 0.001), MSA‐P (median 0.79 × 10−3 mm2/s, P < 0.001), and healthy controls (median 0.80 × 10−3 mm2/s, P < 0.001). DWI discriminated patients with PSP from PD and healthy subjects on the basis of SCP rADC individual values (100% sensitivity and specificity) and from patients with MSA‐P (96.4% sensitivity and 93.3% specificity). The higher values of rADC in SCP of patients with PSP correspond with the in vivo microstructural feature of atrophy detected postmortem and provide an additional support for early discrimination between PSP and other neurodegenerative parkinsonisms. © 2008 Movement Disorder Society</div>
</front>
</TEI>
</ISTEX>
</double>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Apparent diffusion coefficient of the superior cerebellar peduncle differentiates progressive supranuclear palsy from Parkinson's disease

Apparent diffusion coefficient of the superior cerebellar peduncle differentiates progressive supranuclear palsy from Parkinson's disease

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