Cognitive‐nigrostriatal relationships in de novo, drug‐naïve Parkinson's disease patients: A [I‐123]FP‐CIT SPECT study
Identifieur interne : 001D81 ( Main/Curation ); précédent : 001D80; suivant : 001D82Cognitive‐nigrostriatal relationships in de novo, drug‐naïve Parkinson's disease patients: A [I‐123]FP‐CIT SPECT study
Auteurs : Flavio Nobili [Italie] ; Claudio Campus [Italie] ; Dario Arnaldi [Italie] ; Fabrizio De Carli [Italie] ; Gaia Cabassi [Italie] ; Andrea Brugnolo [Italie] ; Barbara Dessi [Italie] ; Silvia Morbelli [Italie] ; Gianmario Sambuceti [Italie] ; Giovanni Abbruzzese [Italie] ; Guido Rodriguez [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-01-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Cognition Disorders (etiology), Cognition Disorders (pathology), Cognition Disorders (radionuclide imaging), Corpus Striatum (radionuclide imaging), DAT uptake, De novo, Factor Analysis, Statistical, Female, Human, Humans, Male, Middle Aged, Nervous system diseases, Neural Pathways (pathology), Neural Pathways (radionuclide imaging), Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (pathology), Parkinson Disease (radionuclide imaging), Parkinson disease, Parkinson's disease, Photon, SPECT, Single photon emission tomography, Substantia Nigra (radionuclide imaging), Tomography, Emission-Computed, Single-Photon (methods), Tropanes (diagnostic use), Uptake, cognitive function, nigrostriatal function.
- MESH :
- chemical , diagnostic use : Tropanes.
- complications : Parkinson Disease.
- etiology : Cognition Disorders.
- methods : Tomography, Emission-Computed, Single-Photon.
- pathology : Cognition Disorders, Neural Pathways, Parkinson Disease.
- radionuclide imaging : Cognition Disorders, Corpus Striatum, Neural Pathways, Parkinson Disease, Substantia Nigra.
- Aged, Factor Analysis, Statistical, Female, Humans, Male, Middle Aged, Neuropsychological Tests.
Abstract
To unveil cognitive‐nigrostriatal correlations in Parkinson's disease (PD), 30 de novo, drug‐naïve PD patients and 15 patients with essential tremor (Controls, CTR) underwent a neuropsychological (NPS) battery and brain SPECT with [I‐123]Ioflupane, as a biomarker of nigrostriatal function. Automatic extraction of uptake at caudate and putamen level was conducted through the BasGan software, also allowing partial volume effect correction. Because of the multicollinearity among neuropsychological tests and among SPECT variables, factor analysis was applied to 16 neuropsychological scores; moreover, the four SPECT variables were merged into a mean SPECT value (mSPECT). Factor analysis identified four NPS factors: a dys‐executive (NPS‐EX), a visuospatial (NPS‐VS), a verbal memory (NPS‐VM), and a “mixed” (NPD‐MIX) factor. In PD group, there were inverse correlations between UPDRS‐III score and both NPS‐VS (P < 0.01) and mSPECT (P < 0.05), and a direct correlation between mSPECT and NPS‐EX (P < 0.05). Post hoc analysis showed a direct correlation between NPS‐EX and caudate uptake in both hemispheres (P < 0.05). Moreover, inverse correlations were found between UPDRS‐III and, respectively, putamen uptake in the less affected hemisphere (P < 0.01), and putamen and caudate uptake in the more affected hemisphere (P < 0.05). In CTR, no correlation was found between mSPECT and either NPS or GDS values. Nigro‐caudate function affects executive capabilities in PD but not in CTR, which appears to be unrelated to the disease motor severity at its onset. Instead, PD motor severity is related to nigro‐putaminal impairment and visuospatial dysfunction. The role of these data as predictive features of cognitive decline and eventually dementia remains to be established in longitudinal studies. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.22899
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<term>Cognition Disorders (pathology)</term>
<term>Cognition Disorders (radionuclide imaging)</term>
<term>Corpus Striatum (radionuclide imaging)</term>
<term>DAT uptake</term>
<term>De novo</term>
<term>Factor Analysis, Statistical</term>
<term>Female</term>
<term>Human</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Neural Pathways (pathology)</term>
<term>Neural Pathways (radionuclide imaging)</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (radionuclide imaging)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
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<term>Single photon emission tomography</term>
<term>Substantia Nigra (radionuclide imaging)</term>
<term>Tomography, Emission-Computed, Single-Photon (methods)</term>
<term>Tropanes (diagnostic use)</term>
<term>Uptake</term>
<term>cognitive function</term>
<term>nigrostriatal function</term>
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<front><div type="abstract" xml:lang="en">To unveil cognitive‐nigrostriatal correlations in Parkinson's disease (PD), 30 de novo, drug‐naïve PD patients and 15 patients with essential tremor (Controls, CTR) underwent a neuropsychological (NPS) battery and brain SPECT with [I‐123]Ioflupane, as a biomarker of nigrostriatal function. Automatic extraction of uptake at caudate and putamen level was conducted through the BasGan software, also allowing partial volume effect correction. Because of the multicollinearity among neuropsychological tests and among SPECT variables, factor analysis was applied to 16 neuropsychological scores; moreover, the four SPECT variables were merged into a mean SPECT value (mSPECT). Factor analysis identified four NPS factors: a dys‐executive (NPS‐EX), a visuospatial (NPS‐VS), a verbal memory (NPS‐VM), and a “mixed” (NPD‐MIX) factor. In PD group, there were inverse correlations between UPDRS‐III score and both NPS‐VS (P < 0.01) and mSPECT (P < 0.05), and a direct correlation between mSPECT and NPS‐EX (P < 0.05). Post hoc analysis showed a direct correlation between NPS‐EX and caudate uptake in both hemispheres (P < 0.05). Moreover, inverse correlations were found between UPDRS‐III and, respectively, putamen uptake in the less affected hemisphere (P < 0.01), and putamen and caudate uptake in the more affected hemisphere (P < 0.05). In CTR, no correlation was found between mSPECT and either NPS or GDS values. Nigro‐caudate function affects executive capabilities in PD but not in CTR, which appears to be unrelated to the disease motor severity at its onset. Instead, PD motor severity is related to nigro‐putaminal impairment and visuospatial dysfunction. The role of these data as predictive features of cognitive decline and eventually dementia remains to be established in longitudinal studies. © 2010 Movement Disorder Society</div>
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<author><name sortKey="Morbelli, Silvia" sort="Morbelli, Silvia" uniqKey="Morbelli S" first="Silvia" last="Morbelli">Silvia Morbelli</name>
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</affiliation>
</author>
<author><name sortKey="Sambuceti, Gianmario" sort="Sambuceti, Gianmario" uniqKey="Sambuceti G" first="Gianmario" last="Sambuceti">Gianmario Sambuceti</name>
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<author><name sortKey="Abbruzzese, Giovanni" sort="Abbruzzese, Giovanni" uniqKey="Abbruzzese G" first="Giovanni" last="Abbruzzese">Giovanni Abbruzzese</name>
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<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rodriguez, Guido" sort="Rodriguez, Guido" uniqKey="Rodriguez G" first="Guido" last="Rodriguez">Guido Rodriguez</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosciences, Ophthalmology and Genetics, Clinical Neurophysiology Unit, University of Genoa</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
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</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">10-0096481</idno>
<date when="2010">2010</date>
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<idno type="RBID">Pascal:10-0096481</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Cognitive-Nigrostriatal Relationships in De Novo, Drug-Naïve Parkinson's Disease Patients: A [I-123]FP-CIT SPECT Study</title>
<author><name sortKey="Nobili, Flavio" sort="Nobili, Flavio" uniqKey="Nobili F" first="Flavio" last="Nobili">Flavio Nobili</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosciences, Ophthalmology and Genetics, Clinical Neurophysiology Unit, University of Genoa</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Campus, Claudio" sort="Campus, Claudio" uniqKey="Campus C" first="Claudio" last="Campus">Claudio Campus</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Telerobotics and Applications Department (TERA), Italian Institute of Technology</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Amaldi, Dario" sort="Amaldi, Dario" uniqKey="Amaldi D" first="Dario" last="Amaldi">Dario Amaldi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosciences, Ophthalmology and Genetics, Clinical Neurophysiology Unit, University of Genoa</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Carli, Fabrizio" sort="De Carli, Fabrizio" uniqKey="De Carli F" first="Fabrizio" last="De Carli">Fabrizio De Carli</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Molecular Bioimaging and Physiology, National Research Council</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cabassi, Gaia" sort="Cabassi, Gaia" uniqKey="Cabassi G" first="Gaia" last="Cabassi">Gaia Cabassi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosciences, Ophthalmology and Genetics, Clinical Neurophysiology Unit, University of Genoa</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brugnolo, Andrea" sort="Brugnolo, Andrea" uniqKey="Brugnolo A" first="Andrea" last="Brugnolo">Andrea Brugnolo</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosciences, Ophthalmology and Genetics, Clinical Neurophysiology Unit, University of Genoa</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dessi, Barbara" sort="Dessi, Barbara" uniqKey="Dessi B" first="Barbara" last="Dessi">Barbara Dessi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosciences, Ophthalmology and Genetics, Clinical Neurophysiology Unit, University of Genoa</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morbelli, Silvia" sort="Morbelli, Silvia" uniqKey="Morbelli S" first="Silvia" last="Morbelli">Silvia Morbelli</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Internal Medicine, Nuclear Medicine Unit, University of Genoa</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sambuceti, Gianmario" sort="Sambuceti, Gianmario" uniqKey="Sambuceti G" first="Gianmario" last="Sambuceti">Gianmario Sambuceti</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Internal Medicine, Nuclear Medicine Unit, University of Genoa</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Abbruzzese, Giovanni" sort="Abbruzzese, Giovanni" uniqKey="Abbruzzese G" first="Giovanni" last="Abbruzzese">Giovanni Abbruzzese</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurosciences, Ophthalmology and Genetics, Centre for Movement Disorders, University of Genoa</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rodriguez, Guido" sort="Rodriguez, Guido" uniqKey="Rodriguez G" first="Guido" last="Rodriguez">Guido Rodriguez</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosciences, Ophthalmology and Genetics, Clinical Neurophysiology Unit, University of Genoa</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>De novo</term>
<term>Human</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Photon</term>
<term>Single photon emission tomography</term>
<term>Uptake</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du système nerveux</term>
<term>De novo</term>
<term>Homme</term>
<term>Tomoscintigraphie émission monophotonique</term>
<term>Photon</term>
<term>Captation</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">To unveil cognitive-nigrostriatal correlations in Parkinson's disease (PD), 30 de novo, drug-naïve PD patients and 15 patients with essential tremor (Controls, CTR) underwent a neuropsychological (NPS) battery and brain SPECT with [I-123]Ioflupane, as a biomarker of nigrostriatal function. Automatic extraction of uptake at caudate and putamen level was conducted through the BasGan software, also allowing partial volume effect correction. Because of the multicollinearity among neuropsychological tests and among SPECT variables, factor analysis was applied to 16 neuropsychological scores; moreover, the four SPECT variables were merged into a mean SPECT value (mSPECT). Factor analysis identified four NPS factors: a dys-executive (NPS-EX), a visuospatial (NPS-VS), a verbal memory (NPS-VM), and a "mixed" (NPD-MIX) factor. In PD group, there were inverse correlations between UPDRS-III score and both NPS-VS (P < 0.01) and mSPECT (P < 0.05), and a direct correlation between mSPECT and NPS-EX (P < 0.05). Post hoc analysis showed a direct correlation between NPS-EX and caudate uptake in both hemispheres (P < 0.05). Moreover, inverse correlations were found between UPDRS-III and, respectively, putamen uptake in the less affected hemisphere (P < 0.01), and putamen and caudate uptake in the more affected hemisphere (P < 0.05). In CTR, no correlation was found between mSPECT and either NPS or GDS values. Nigro-caudate function affects executive capabilities in PD but not in CTR, which appears to be unrelated to the disease motor severity at its onset. Instead, PD motor severity is related to nigro-putaminal impairment and visuospatial dysfunction. The role of these data as predictive features of cognitive decline and eventually dementia remains to be established in longitudinal studies.</div>
</front>
</TEI>
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<author><name sortKey="Nobili, Flavio" sort="Nobili, Flavio" uniqKey="Nobili F" first="Flavio" last="Nobili">Flavio Nobili</name>
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<author><name sortKey="De Carli, Fabrizio" sort="De Carli, Fabrizio" uniqKey="De Carli F" first="Fabrizio" last="De Carli">Fabrizio De Carli</name>
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<author><name sortKey="Rodriguez, Guido" sort="Rodriguez, Guido" uniqKey="Rodriguez G" first="Guido" last="Rodriguez">Guido Rodriguez</name>
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<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurosciences, Ophthalmology and Genetics, Clinical Neurophysiology Unit, University of Genoa, Genoa</wicri:regionArea>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Campus, Claudio" sort="Campus, Claudio" uniqKey="Campus C" first="Claudio" last="Campus">Claudio Campus</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Telerobotics and Applications Department (TERA), Italian Institute of Technology, Genoa</wicri:regionArea>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Arnaldi, Dario" sort="Arnaldi, Dario" uniqKey="Arnaldi D" first="Dario" last="Arnaldi">Dario Arnaldi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurosciences, Ophthalmology and Genetics, Clinical Neurophysiology Unit, University of Genoa, Genoa</wicri:regionArea>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Carli, Fabrizio" sort="De Carli, Fabrizio" uniqKey="De Carli F" first="Fabrizio" last="De Carli">Fabrizio De Carli</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Molecular Bioimaging and Physiology, National Research Council, Genoa</wicri:regionArea>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cabassi, Gaia" sort="Cabassi, Gaia" uniqKey="Cabassi G" first="Gaia" last="Cabassi">Gaia Cabassi</name>
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<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brugnolo, Andrea" sort="Brugnolo, Andrea" uniqKey="Brugnolo A" first="Andrea" last="Brugnolo">Andrea Brugnolo</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurosciences, Ophthalmology and Genetics, Clinical Neurophysiology Unit, University of Genoa, Genoa</wicri:regionArea>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dessi, Barbara" sort="Dessi, Barbara" uniqKey="Dessi B" first="Barbara" last="Dessi">Barbara Dessi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurosciences, Ophthalmology and Genetics, Clinical Neurophysiology Unit, University of Genoa, Genoa</wicri:regionArea>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morbelli, Silvia" sort="Morbelli, Silvia" uniqKey="Morbelli S" first="Silvia" last="Morbelli">Silvia Morbelli</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Internal Medicine, Nuclear Medicine Unit, University of Genoa, Genoa</wicri:regionArea>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sambuceti, Gianmario" sort="Sambuceti, Gianmario" uniqKey="Sambuceti G" first="Gianmario" last="Sambuceti">Gianmario Sambuceti</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Internal Medicine, Nuclear Medicine Unit, University of Genoa, Genoa</wicri:regionArea>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Abbruzzese, Giovanni" sort="Abbruzzese, Giovanni" uniqKey="Abbruzzese G" first="Giovanni" last="Abbruzzese">Giovanni Abbruzzese</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurosciences, Ophthalmology and Genetics, Centre for Movement Disorders, University of Genoa, Genoa</wicri:regionArea>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rodriguez, Guido" sort="Rodriguez, Guido" uniqKey="Rodriguez G" first="Guido" last="Rodriguez">Guido Rodriguez</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurosciences, Ophthalmology and Genetics, Clinical Neurophysiology Unit, University of Genoa, Genoa</wicri:regionArea>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2010-01-15">2010-01-15</date>
<biblScope unit="vol">25</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="35">35</biblScope>
<biblScope unit="page" to="43">43</biblScope>
</imprint>
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</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Cognition Disorders (etiology)</term>
<term>Cognition Disorders (pathology)</term>
<term>Cognition Disorders (radionuclide imaging)</term>
<term>Corpus Striatum (radionuclide imaging)</term>
<term>DAT uptake</term>
<term>Factor Analysis, Statistical</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neural Pathways (pathology)</term>
<term>Neural Pathways (radionuclide imaging)</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (radionuclide imaging)</term>
<term>Parkinson's disease</term>
<term>SPECT</term>
<term>Substantia Nigra (radionuclide imaging)</term>
<term>Tomography, Emission-Computed, Single-Photon (methods)</term>
<term>Tropanes (diagnostic use)</term>
<term>cognitive function</term>
<term>nigrostriatal function</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Tropanes</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tomography, Emission-Computed, Single-Photon</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cognition Disorders</term>
<term>Neural Pathways</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Cognition Disorders</term>
<term>Corpus Striatum</term>
<term>Neural Pathways</term>
<term>Parkinson Disease</term>
<term>Substantia Nigra</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Factor Analysis, Statistical</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
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<front><div type="abstract" xml:lang="en">To unveil cognitive‐nigrostriatal correlations in Parkinson's disease (PD), 30 de novo, drug‐naïve PD patients and 15 patients with essential tremor (Controls, CTR) underwent a neuropsychological (NPS) battery and brain SPECT with [I‐123]Ioflupane, as a biomarker of nigrostriatal function. Automatic extraction of uptake at caudate and putamen level was conducted through the BasGan software, also allowing partial volume effect correction. Because of the multicollinearity among neuropsychological tests and among SPECT variables, factor analysis was applied to 16 neuropsychological scores; moreover, the four SPECT variables were merged into a mean SPECT value (mSPECT). Factor analysis identified four NPS factors: a dys‐executive (NPS‐EX), a visuospatial (NPS‐VS), a verbal memory (NPS‐VM), and a “mixed” (NPD‐MIX) factor. In PD group, there were inverse correlations between UPDRS‐III score and both NPS‐VS (P < 0.01) and mSPECT (P < 0.05), and a direct correlation between mSPECT and NPS‐EX (P < 0.05). Post hoc analysis showed a direct correlation between NPS‐EX and caudate uptake in both hemispheres (P < 0.05). Moreover, inverse correlations were found between UPDRS‐III and, respectively, putamen uptake in the less affected hemisphere (P < 0.01), and putamen and caudate uptake in the more affected hemisphere (P < 0.05). In CTR, no correlation was found between mSPECT and either NPS or GDS values. Nigro‐caudate function affects executive capabilities in PD but not in CTR, which appears to be unrelated to the disease motor severity at its onset. Instead, PD motor severity is related to nigro‐putaminal impairment and visuospatial dysfunction. The role of these data as predictive features of cognitive decline and eventually dementia remains to be established in longitudinal studies. © 2010 Movement Disorder Society</div>
</front>
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