Minocycline 1‐year therapy in multiple‐system‐atrophy: Effect on clinical symptoms and [11C] (R)‐PK11195 PET (MEMSA‐trial)
Identifieur interne : 001B81 ( Main/Curation ); précédent : 001B80; suivant : 001B82Minocycline 1‐year therapy in multiple‐system‐atrophy: Effect on clinical symptoms and [11C] (R)‐PK11195 PET (MEMSA‐trial)
Auteurs : Richard Dodel [Allemagne] ; Annika Spottke [Allemagne] ; Alexander Gerhard [Royaume-Uni] ; Alexander Reuss [Allemagne] ; Sylvia Reinecker [Allemagne] ; Nicole Schimke [Allemagne] ; Claudia Trenkwalder [Allemagne] ; Friederike Sixel-Döring [Allemagne] ; Birgit Herting [Allemagne] ; Christoph Kamm [Allemagne] ; Thomas Gasser [Allemagne] ; Martin Sawires [Autriche] ; Felix Geser [Autriche] ; Martin Köllensperger [Autriche] ; Klaus Seppi [Autriche] ; Manja Kloss [Allemagne] ; Martin Krause [Allemagne] ; Christine Daniels [Allemagne] ; Günther Deuschl [Allemagne] ; Silke Böttger [Allemagne] ; Markus Naumann [Allemagne] ; Axel Lipp [Royaume-Uni] ; Doreen Gruber [Allemagne] ; Andreas Kupsch [Allemagne] ; Yansheng Du [États-Unis] ; Federico Turkheimer [Royaume-Uni] ; David J. Brooks [Royaume-Uni] ; Thomas Klockgether [Allemagne] ; Werner Poewe [Autriche] ; Gregor Wenning [Autriche] ; Carmen Schade-Brittinger [Allemagne] ; Wolfgang H. Oertel [Allemagne] ; Karla Eggert [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-01-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Double-Blind Method, Emission tomography, Female, Follow-Up Studies, Humans, Isoquinolines (diagnostic use), Magnetic Resonance Imaging (methods), Male, Middle Aged, Minocycline, Minocycline (therapeutic use), Multiple System Atrophy (drug therapy), Multiple System Atrophy (psychology), Multiple System Atrophy (radionuclide imaging), Multiple system atrophy, Nervous system diseases, Neuroprotective Agents (therapeutic use), PET, Positron emission tomography, Positron-Emission Tomography (methods), Quality of Life, Severity of Illness Index, Statistics, Nonparametric, Time Factors, Treatment, Treatment Outcome, minocycline, multiple system atrophy.
- MESH :
- chemical , diagnostic use : Isoquinolines.
- drug therapy : Multiple System Atrophy.
- methods : Magnetic Resonance Imaging, Positron-Emission Tomography.
- psychology : Multiple System Atrophy.
- radionuclide imaging : Multiple System Atrophy.
- chemical , therapeutic use : Minocycline, Neuroprotective Agents.
- Adult, Aged, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Middle Aged, Quality of Life, Severity of Illness Index, Statistics, Nonparametric, Time Factors, Treatment Outcome.
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple‐System‐Atrophy Parkinson‐type (MSA‐P). Sixty‐three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary outcome variable was the change in the value of the motor score of the Unified Multiple‐System‐Atrophy Rating‐Scale (UMSARSII) from baseline to 48 weeks. Secondary outcome variables included subscores and individual Parkinsonian symptoms as determined by the UMSARS and the Unified‐Parkinson's‐Disease Rating‐Scale (UPDRS). Health‐related quality of life (HrQoL) was assessed using the EQ‐5D and SF‐12. “Progression rate” was assumed to be reflected in the change in motor function over 48 weeks. At 24 weeks and 48 weeks of follow‐up, there was a significant deterioration in motor scores in both groups, but neither the change in UMSARSII nor in UPDRSIII differed significantly between treatment groups, i.e. “progression rate” was considered to be similar in both treatment arms. HrQoL did not differ among the two treatment arms. In a small subgroup of patients (n = 8; minocycline = 3, placebo = 5)[11C](R)‐PK11195‐PET was performed. The three patients in the minocycline group had an attenuated mean increase in microglial activation as compared to the placebo group (P = 0.07) and in two of them individually showed decreased [11C](R)‐PK11195 binding actually decreased. These preliminary PET‐data suggest that minocycline may interfere with microglial activation. The relevance of this observation requires further investigation. This prospective, 48 week, randomized, double‐blind, multinational study failed to show a clinical effect of minocycline on symptom severity as assessed by clinical motor function. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22732
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<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
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<author><name sortKey="Geser, Felix" sort="Geser, Felix" uniqKey="Geser F" first="Felix" last="Geser">Felix Geser</name>
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<author><name sortKey="Kollensperger, Martin" sort="Kollensperger, Martin" uniqKey="Kollensperger M" first="Martin" last="Köllensperger">Martin Köllensperger</name>
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<author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name>
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<author><name sortKey="Kloss, Manja" sort="Kloss, Manja" uniqKey="Kloss M" first="Manja" last="Kloss">Manja Kloss</name>
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<author><name sortKey="Krause, Martin" sort="Krause, Martin" uniqKey="Krause M" first="Martin" last="Krause">Martin Krause</name>
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<wicri:noRegion>University of Heidelberg</wicri:noRegion>
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<author><name sortKey="Daniels, Christine" sort="Daniels, Christine" uniqKey="Daniels C" first="Christine" last="Daniels">Christine Daniels</name>
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<wicri:regionArea>Department of Neurology, University of Kiel</wicri:regionArea>
<wicri:noRegion>University of Kiel</wicri:noRegion>
<wicri:noRegion>University of Kiel</wicri:noRegion>
</affiliation>
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<author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name>
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<author><name sortKey="Bottger, Silke" sort="Bottger, Silke" uniqKey="Bottger S" first="Silke" last="Böttger">Silke Böttger</name>
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<wicri:regionArea>Department of Neurology, University of Würzburg</wicri:regionArea>
<wicri:noRegion>University of Würzburg</wicri:noRegion>
<wicri:noRegion>University of Würzburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Naumann, Markus" sort="Naumann, Markus" uniqKey="Naumann M" first="Markus" last="Naumann">Markus Naumann</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Würzburg</wicri:regionArea>
<wicri:noRegion>University of Würzburg</wicri:noRegion>
<wicri:noRegion>University of Würzburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lipp, Axel" sort="Lipp, Axel" uniqKey="Lipp A" first="Axel" last="Lipp">Axel Lipp</name>
<affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wolfson Molecular Imaging Centre, The University of Manchester</wicri:regionArea>
<placeName><settlement type="city">Manchester</settlement>
<region type="nation">Angleterre</region>
<region nuts="2" type="region">Grand Manchester</region>
</placeName>
<orgName type="university">Université de Manchester</orgName>
</affiliation>
</author>
<author><name sortKey="Gruber, Doreen" sort="Gruber, Doreen" uniqKey="Gruber D" first="Doreen" last="Gruber">Doreen Gruber</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Berlin</wicri:regionArea>
<wicri:noRegion>University of Berlin</wicri:noRegion>
<wicri:noRegion>University of Berlin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Berlin</wicri:regionArea>
<wicri:noRegion>University of Berlin</wicri:noRegion>
<wicri:noRegion>University of Berlin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Du, Yansheng" sort="Du, Yansheng" uniqKey="Du Y" first="Yansheng" last="Du">Yansheng Du</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Indiana University Medical School, Indianapolis, Indiana</wicri:regionArea>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Turkheimer, Federico" sort="Turkheimer, Federico" uniqKey="Turkheimer F" first="Federico" last="Turkheimer">Federico Turkheimer</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>IMRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College; London</wicri:regionArea>
<wicri:noRegion>Imperial College; London</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>IMRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College; London</wicri:regionArea>
<wicri:noRegion>Imperial College; London</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name>
<affiliation wicri:level="4"><country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University of Innsbruck</wicri:regionArea>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Autriche</country>
<wicri:regionArea>European MSA Study Group, Innsbruck Medical University</wicri:regionArea>
<wicri:noRegion>Innsbruck Medical University</wicri:noRegion>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
</author>
<author><name sortKey="Wenning, Gregor" sort="Wenning, Gregor" uniqKey="Wenning G" first="Gregor" last="Wenning">Gregor Wenning</name>
<affiliation wicri:level="4"><country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University of Innsbruck</wicri:regionArea>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Autriche</country>
<wicri:regionArea>European MSA Study Group, Innsbruck Medical University</wicri:regionArea>
<wicri:noRegion>Innsbruck Medical University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schade Rittinger, Carmen" sort="Schade Rittinger, Carmen" uniqKey="Schade Rittinger C" first="Carmen" last="Schade-Brittinger">Carmen Schade-Brittinger</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Coordinating Center for Clinical Trials, Philipps‐University of Marburg</wicri:regionArea>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
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<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Philipps‐University of Marburg</wicri:regionArea>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Competence Network Parkinson‐Syndrome, Philipps‐University of Marburg</wicri:regionArea>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eggert, Karla" sort="Eggert, Karla" uniqKey="Eggert K" first="Karla" last="Eggert">Karla Eggert</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Philipps‐University of Marburg</wicri:regionArea>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Competence Network Parkinson‐Syndrome, Philipps‐University of Marburg</wicri:regionArea>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
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<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2010-01-15">2010-01-15</date>
<biblScope unit="vol">25</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="97">97</biblScope>
<biblScope unit="page" to="107">107</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">7E3C331E554F887479122609783881EAE1EEE31D</idno>
<idno type="DOI">10.1002/mds.22732</idno>
<idno type="ArticleID">MDS22732</idno>
</biblStruct>
</sourceDesc>
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</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Double-Blind Method</term>
<term>Emission tomography</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Isoquinolines (diagnostic use)</term>
<term>Magnetic Resonance Imaging (methods)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Minocycline</term>
<term>Minocycline (therapeutic use)</term>
<term>Multiple System Atrophy (drug therapy)</term>
<term>Multiple System Atrophy (psychology)</term>
<term>Multiple System Atrophy (radionuclide imaging)</term>
<term>Multiple system atrophy</term>
<term>Nervous system diseases</term>
<term>Neuroprotective Agents (therapeutic use)</term>
<term>PET</term>
<term>Positron emission tomography</term>
<term>Positron-Emission Tomography (methods)</term>
<term>Quality of Life</term>
<term>Severity of Illness Index</term>
<term>Statistics, Nonparametric</term>
<term>Time Factors</term>
<term>Treatment</term>
<term>Treatment Outcome</term>
<term>minocycline</term>
<term>multiple system atrophy</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Isoquinolines</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Multiple System Atrophy</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term>
<term>Positron-Emission Tomography</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Multiple System Atrophy</term>
</keywords>
<keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Multiple System Atrophy</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Minocycline</term>
<term>Neuroprotective Agents</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Quality of Life</term>
<term>Severity of Illness Index</term>
<term>Statistics, Nonparametric</term>
<term>Time Factors</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Atrophie multisystématisée</term>
<term>Minocycline</term>
<term>Pathologie du système nerveux</term>
<term>Tomographie par émission de positons</term>
<term>Tomoscintigraphie</term>
<term>Traitement</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
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</teiHeader>
<front><div type="abstract" xml:lang="en">The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple‐System‐Atrophy Parkinson‐type (MSA‐P). Sixty‐three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary outcome variable was the change in the value of the motor score of the Unified Multiple‐System‐Atrophy Rating‐Scale (UMSARSII) from baseline to 48 weeks. Secondary outcome variables included subscores and individual Parkinsonian symptoms as determined by the UMSARS and the Unified‐Parkinson's‐Disease Rating‐Scale (UPDRS). Health‐related quality of life (HrQoL) was assessed using the EQ‐5D and SF‐12. “Progression rate” was assumed to be reflected in the change in motor function over 48 weeks. At 24 weeks and 48 weeks of follow‐up, there was a significant deterioration in motor scores in both groups, but neither the change in UMSARSII nor in UPDRSIII differed significantly between treatment groups, i.e. “progression rate” was considered to be similar in both treatment arms. HrQoL did not differ among the two treatment arms. In a small subgroup of patients (n = 8; minocycline = 3, placebo = 5)[11C](R)‐PK11195‐PET was performed. The three patients in the minocycline group had an attenuated mean increase in microglial activation as compared to the placebo group (P = 0.07) and in two of them individually showed decreased [11C](R)‐PK11195 binding actually decreased. These preliminary PET‐data suggest that minocycline may interfere with microglial activation. The relevance of this observation requires further investigation. This prospective, 48 week, randomized, double‐blind, multinational study failed to show a clinical effect of minocycline on symptom severity as assessed by clinical motor function. © 2009 Movement Disorder Society</div>
</front>
</TEI>
<double idat="0885-3185:2010:Dodel R:minocycline:year:therapy"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Minocycline 1-Year Therapy in Multiple-System-Atrophy: Effect on Clinical Symptoms and [<sup>11</sup>
C] (R)-PK11195 PET (MEMSA-Trial)</title>
<author><name sortKey="Dodel, Richard" sort="Dodel, Richard" uniqKey="Dodel R" first="Richard" last="Dodel">Richard Dodel</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps-University of Marburg</s1>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Philipps-University of Marburg</wicri:noRegion>
<wicri:noRegion>Department of Neurology, Philipps-University of Marburg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Bonn</s1>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>Department of Neurology, University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Spottke, Annika" sort="Spottke, Annika" uniqKey="Spottke A" first="Annika" last="Spottke">Annika Spottke</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Bonn</s1>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>Department of Neurology, University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gerhard, Alexander" sort="Gerhard, Alexander" uniqKey="Gerhard A" first="Alexander" last="Gerhard">Alexander Gerhard</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Wolfson Molecular Imaging Centre, The University of Manchester</s1>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Manchester</settlement>
<region type="nation">Angleterre</region>
<region nuts="2" type="region">Grand Manchester</region>
</placeName>
<orgName type="university">Université de Manchester</orgName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="16"><s1>IMRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reuss, Alexander" sort="Reuss, Alexander" uniqKey="Reuss A" first="Alexander" last="Reuss">Alexander Reuss</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Coordinating Center for Clinical Trials, Philipps-University of Marburg</s1>
<s3>DEU</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Philipps-University of Marburg</wicri:noRegion>
<wicri:noRegion>Coordinating Center for Clinical Trials, Philipps-University of Marburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Reinecker, Sylvia" sort="Reinecker, Sylvia" uniqKey="Reinecker S" first="Sylvia" last="Reinecker">Sylvia Reinecker</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Coordinating Center for Clinical Trials, Philipps-University of Marburg</s1>
<s3>DEU</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Philipps-University of Marburg</wicri:noRegion>
<wicri:noRegion>Coordinating Center for Clinical Trials, Philipps-University of Marburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schimke, Nicole" sort="Schimke, Nicole" uniqKey="Schimke N" first="Nicole" last="Schimke">Nicole Schimke</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps-University of Marburg</s1>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Philipps-University of Marburg</wicri:noRegion>
<wicri:noRegion>Department of Neurology, Philipps-University of Marburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Paracelsus-Elena-Clinic Kassel</s1>
<s3>DEU</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Paracelsus-Elena-Clinic Kassel</wicri:noRegion>
<wicri:noRegion>Paracelsus-Elena-Clinic Kassel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sixel Doring, Friederike" sort="Sixel Doring, Friederike" uniqKey="Sixel Doring F" first="Friederike" last="Sixel-Döring">Friederike Sixel-Döring</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Paracelsus-Elena-Clinic Kassel</s1>
<s3>DEU</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Paracelsus-Elena-Clinic Kassel</wicri:noRegion>
<wicri:noRegion>Paracelsus-Elena-Clinic Kassel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Herting, Birgit" sort="Herting, Birgit" uniqKey="Herting B" first="Birgit" last="Herting">Birgit Herting</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Neurology, Dresden University of Technology</s1>
<s3>DEU</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Dresden University of Technology</wicri:noRegion>
<wicri:noRegion>Department of Neurology, Dresden University of Technology</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kamm, Christoph" sort="Kamm, Christoph" uniqKey="Kamm C" first="Christoph" last="Kamm">Christoph Kamm</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Hertie-Institute, University of Tübingen</s1>
<s3>DEU</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Tübingen</wicri:noRegion>
<wicri:noRegion>Hertie-Institute, University of Tübingen</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Neurology, University of Rostock</s1>
<s3>DEU</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Rostock</wicri:noRegion>
<wicri:noRegion>Department of Neurology, University of Rostock</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Hertie-Institute, University of Tübingen</s1>
<s3>DEU</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Tübingen</wicri:noRegion>
<wicri:noRegion>Hertie-Institute, University of Tübingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sawires, Martin" sort="Sawires, Martin" uniqKey="Sawires M" first="Martin" last="Sawires">Martin Sawires</name>
<affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Department of Neurology, Medical University of Innsbruck</s1>
<s3>AUT</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
</author>
<author><name sortKey="Geser, Felix" sort="Geser, Felix" uniqKey="Geser F" first="Felix" last="Geser">Felix Geser</name>
<affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Department of Neurology, Medical University of Innsbruck</s1>
<s3>AUT</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>European MSA Study Group, Innsbruck Medical University</s1>
<s3>AUT</s3>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>European MSA Study Group, Innsbruck Medical University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kollensperger, Martin" sort="Kollensperger, Martin" uniqKey="Kollensperger M" first="Martin" last="Köllensperger">Martin Köllensperger</name>
<affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Department of Neurology, Medical University of Innsbruck</s1>
<s3>AUT</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
</author>
<author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name>
<affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Department of Neurology, Medical University of Innsbruck</s1>
<s3>AUT</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>European MSA Study Group, Innsbruck Medical University</s1>
<s3>AUT</s3>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>European MSA Study Group, Innsbruck Medical University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kloss, Manja" sort="Kloss, Manja" uniqKey="Kloss M" first="Manja" last="Kloss">Manja Kloss</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Neurology, University of Heidelberg</s1>
<s3>DEU</s3>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Heidelberg</wicri:noRegion>
<wicri:noRegion>Department of Neurology, University of Heidelberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Krause, Martin" sort="Krause, Martin" uniqKey="Krause M" first="Martin" last="Krause">Martin Krause</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Neurology, University of Heidelberg</s1>
<s3>DEU</s3>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Heidelberg</wicri:noRegion>
<wicri:noRegion>Department of Neurology, University of Heidelberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Daniels, Christine" sort="Daniels, Christine" uniqKey="Daniels C" first="Christine" last="Daniels">Christine Daniels</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Neurology, University of Kiel</s1>
<s3>DEU</s3>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Kiel</wicri:noRegion>
<wicri:noRegion>Department of Neurology, University of Kiel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Neurology, University of Kiel</s1>
<s3>DEU</s3>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Kiel</wicri:noRegion>
<wicri:noRegion>Department of Neurology, University of Kiel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bottger, Silke" sort="Bottger, Silke" uniqKey="Bottger S" first="Silke" last="Böttger">Silke Böttger</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Neurology, University of Würzburg</s1>
<s3>DEU</s3>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Würzburg</wicri:noRegion>
<wicri:noRegion>Department of Neurology, University of Würzburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Naumann, Markus" sort="Naumann, Markus" uniqKey="Naumann M" first="Markus" last="Naumann">Markus Naumann</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Neurology, University of Würzburg</s1>
<s3>DEU</s3>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Würzburg</wicri:noRegion>
<wicri:noRegion>Department of Neurology, University of Würzburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lipp, Axel" sort="Lipp, Axel" uniqKey="Lipp A" first="Axel" last="Lipp">Axel Lipp</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Wolfson Molecular Imaging Centre, The University of Manchester</s1>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Manchester</settlement>
<region type="nation">Angleterre</region>
<region nuts="2" type="region">Grand Manchester</region>
</placeName>
<orgName type="university">Université de Manchester</orgName>
</affiliation>
</author>
<author><name sortKey="Gruber, Doreen" sort="Gruber, Doreen" uniqKey="Gruber D" first="Doreen" last="Gruber">Doreen Gruber</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Neurology, University of Berlin</s1>
<s3>DEU</s3>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Berlin</wicri:noRegion>
<wicri:noRegion>Department of Neurology, University of Berlin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Neurology, University of Berlin</s1>
<s3>DEU</s3>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Berlin</wicri:noRegion>
<wicri:noRegion>Department of Neurology, University of Berlin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yansheng Du" sort="Yansheng Du" uniqKey="Yansheng Du" last="Yansheng Du">YANSHENG DU</name>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Neurology, Indiana University Medical School</s1>
<s2>Indianapolis, Indiana</s2>
<s3>USA</s3>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Turkheimer, Federico" sort="Turkheimer, Federico" uniqKey="Turkheimer F" first="Federico" last="Turkheimer">Federico Turkheimer</name>
<affiliation wicri:level="3"><inist:fA14 i1="16"><s1>IMRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name>
<affiliation wicri:level="3"><inist:fA14 i1="16"><s1>IMRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Bonn</s1>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>Department of Neurology, University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name>
<affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Department of Neurology, Medical University of Innsbruck</s1>
<s3>AUT</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>European MSA Study Group, Innsbruck Medical University</s1>
<s3>AUT</s3>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>European MSA Study Group, Innsbruck Medical University</wicri:noRegion>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
</author>
<author><name sortKey="Wenning, Gregor" sort="Wenning, Gregor" uniqKey="Wenning G" first="Gregor" last="Wenning">Gregor Wenning</name>
<affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Department of Neurology, Medical University of Innsbruck</s1>
<s3>AUT</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>European MSA Study Group, Innsbruck Medical University</s1>
<s3>AUT</s3>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>European MSA Study Group, Innsbruck Medical University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schade Brittinger, Carmen" sort="Schade Brittinger, Carmen" uniqKey="Schade Brittinger C" first="Carmen" last="Schade-Brittinger">Carmen Schade-Brittinger</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Coordinating Center for Clinical Trials, Philipps-University of Marburg</s1>
<s3>DEU</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Philipps-University of Marburg</wicri:noRegion>
<wicri:noRegion>Coordinating Center for Clinical Trials, Philipps-University of Marburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps-University of Marburg</s1>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Philipps-University of Marburg</wicri:noRegion>
<wicri:noRegion>Department of Neurology, Philipps-University of Marburg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Competence Network Parkinson-Syndrome, Philipps-University of Marburg</s1>
<s3>DEU</s3>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Philipps-University of Marburg</wicri:noRegion>
<wicri:noRegion>Competence Network Parkinson-Syndrome, Philipps-University of Marburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eggert, Karla" sort="Eggert, Karla" uniqKey="Eggert K" first="Karla" last="Eggert">Karla Eggert</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps-University of Marburg</s1>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Philipps-University of Marburg</wicri:noRegion>
<wicri:noRegion>Department of Neurology, Philipps-University of Marburg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Competence Network Parkinson-Syndrome, Philipps-University of Marburg</s1>
<s3>DEU</s3>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Philipps-University of Marburg</wicri:noRegion>
<wicri:noRegion>Competence Network Parkinson-Syndrome, Philipps-University of Marburg</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">10-0096516</idno>
<date when="2010">2010</date>
<idno type="stanalyst">PASCAL 10-0096516 INIST</idno>
<idno type="RBID">Pascal:10-0096516</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000C46</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002073</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000964</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Dodel R:minocycline:year:therapy</idno>
<idno type="wicri:Area/Main/Merge">002551</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Minocycline 1-Year Therapy in Multiple-System-Atrophy: Effect on Clinical Symptoms and [<sup>11</sup>
C] (R)-PK11195 PET (MEMSA-Trial)</title>
<author><name sortKey="Dodel, Richard" sort="Dodel, Richard" uniqKey="Dodel R" first="Richard" last="Dodel">Richard Dodel</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps-University of Marburg</s1>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Philipps-University of Marburg</wicri:noRegion>
<wicri:noRegion>Department of Neurology, Philipps-University of Marburg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Bonn</s1>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>Department of Neurology, University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Spottke, Annika" sort="Spottke, Annika" uniqKey="Spottke A" first="Annika" last="Spottke">Annika Spottke</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Bonn</s1>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>Department of Neurology, University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gerhard, Alexander" sort="Gerhard, Alexander" uniqKey="Gerhard A" first="Alexander" last="Gerhard">Alexander Gerhard</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Wolfson Molecular Imaging Centre, The University of Manchester</s1>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Manchester</settlement>
<region type="nation">Angleterre</region>
<region nuts="2" type="region">Grand Manchester</region>
</placeName>
<orgName type="university">Université de Manchester</orgName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="16"><s1>IMRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reuss, Alexander" sort="Reuss, Alexander" uniqKey="Reuss A" first="Alexander" last="Reuss">Alexander Reuss</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Coordinating Center for Clinical Trials, Philipps-University of Marburg</s1>
<s3>DEU</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Philipps-University of Marburg</wicri:noRegion>
<wicri:noRegion>Coordinating Center for Clinical Trials, Philipps-University of Marburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Reinecker, Sylvia" sort="Reinecker, Sylvia" uniqKey="Reinecker S" first="Sylvia" last="Reinecker">Sylvia Reinecker</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Coordinating Center for Clinical Trials, Philipps-University of Marburg</s1>
<s3>DEU</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Philipps-University of Marburg</wicri:noRegion>
<wicri:noRegion>Coordinating Center for Clinical Trials, Philipps-University of Marburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schimke, Nicole" sort="Schimke, Nicole" uniqKey="Schimke N" first="Nicole" last="Schimke">Nicole Schimke</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps-University of Marburg</s1>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Philipps-University of Marburg</wicri:noRegion>
<wicri:noRegion>Department of Neurology, Philipps-University of Marburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Paracelsus-Elena-Clinic Kassel</s1>
<s3>DEU</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Paracelsus-Elena-Clinic Kassel</wicri:noRegion>
<wicri:noRegion>Paracelsus-Elena-Clinic Kassel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sixel Doring, Friederike" sort="Sixel Doring, Friederike" uniqKey="Sixel Doring F" first="Friederike" last="Sixel-Döring">Friederike Sixel-Döring</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Paracelsus-Elena-Clinic Kassel</s1>
<s3>DEU</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Paracelsus-Elena-Clinic Kassel</wicri:noRegion>
<wicri:noRegion>Paracelsus-Elena-Clinic Kassel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Herting, Birgit" sort="Herting, Birgit" uniqKey="Herting B" first="Birgit" last="Herting">Birgit Herting</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Neurology, Dresden University of Technology</s1>
<s3>DEU</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Dresden University of Technology</wicri:noRegion>
<wicri:noRegion>Department of Neurology, Dresden University of Technology</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kamm, Christoph" sort="Kamm, Christoph" uniqKey="Kamm C" first="Christoph" last="Kamm">Christoph Kamm</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Hertie-Institute, University of Tübingen</s1>
<s3>DEU</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Tübingen</wicri:noRegion>
<wicri:noRegion>Hertie-Institute, University of Tübingen</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Neurology, University of Rostock</s1>
<s3>DEU</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Rostock</wicri:noRegion>
<wicri:noRegion>Department of Neurology, University of Rostock</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Hertie-Institute, University of Tübingen</s1>
<s3>DEU</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Tübingen</wicri:noRegion>
<wicri:noRegion>Hertie-Institute, University of Tübingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sawires, Martin" sort="Sawires, Martin" uniqKey="Sawires M" first="Martin" last="Sawires">Martin Sawires</name>
<affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Department of Neurology, Medical University of Innsbruck</s1>
<s3>AUT</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
</author>
<author><name sortKey="Geser, Felix" sort="Geser, Felix" uniqKey="Geser F" first="Felix" last="Geser">Felix Geser</name>
<affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Department of Neurology, Medical University of Innsbruck</s1>
<s3>AUT</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>European MSA Study Group, Innsbruck Medical University</s1>
<s3>AUT</s3>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>European MSA Study Group, Innsbruck Medical University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kollensperger, Martin" sort="Kollensperger, Martin" uniqKey="Kollensperger M" first="Martin" last="Köllensperger">Martin Köllensperger</name>
<affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Department of Neurology, Medical University of Innsbruck</s1>
<s3>AUT</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
</author>
<author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name>
<affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Department of Neurology, Medical University of Innsbruck</s1>
<s3>AUT</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>European MSA Study Group, Innsbruck Medical University</s1>
<s3>AUT</s3>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>European MSA Study Group, Innsbruck Medical University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kloss, Manja" sort="Kloss, Manja" uniqKey="Kloss M" first="Manja" last="Kloss">Manja Kloss</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Neurology, University of Heidelberg</s1>
<s3>DEU</s3>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Heidelberg</wicri:noRegion>
<wicri:noRegion>Department of Neurology, University of Heidelberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Krause, Martin" sort="Krause, Martin" uniqKey="Krause M" first="Martin" last="Krause">Martin Krause</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Neurology, University of Heidelberg</s1>
<s3>DEU</s3>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Heidelberg</wicri:noRegion>
<wicri:noRegion>Department of Neurology, University of Heidelberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Daniels, Christine" sort="Daniels, Christine" uniqKey="Daniels C" first="Christine" last="Daniels">Christine Daniels</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Neurology, University of Kiel</s1>
<s3>DEU</s3>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Kiel</wicri:noRegion>
<wicri:noRegion>Department of Neurology, University of Kiel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Neurology, University of Kiel</s1>
<s3>DEU</s3>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Kiel</wicri:noRegion>
<wicri:noRegion>Department of Neurology, University of Kiel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bottger, Silke" sort="Bottger, Silke" uniqKey="Bottger S" first="Silke" last="Böttger">Silke Böttger</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Neurology, University of Würzburg</s1>
<s3>DEU</s3>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Würzburg</wicri:noRegion>
<wicri:noRegion>Department of Neurology, University of Würzburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Naumann, Markus" sort="Naumann, Markus" uniqKey="Naumann M" first="Markus" last="Naumann">Markus Naumann</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Neurology, University of Würzburg</s1>
<s3>DEU</s3>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Würzburg</wicri:noRegion>
<wicri:noRegion>Department of Neurology, University of Würzburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lipp, Axel" sort="Lipp, Axel" uniqKey="Lipp A" first="Axel" last="Lipp">Axel Lipp</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Wolfson Molecular Imaging Centre, The University of Manchester</s1>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Manchester</settlement>
<region type="nation">Angleterre</region>
<region nuts="2" type="region">Grand Manchester</region>
</placeName>
<orgName type="university">Université de Manchester</orgName>
</affiliation>
</author>
<author><name sortKey="Gruber, Doreen" sort="Gruber, Doreen" uniqKey="Gruber D" first="Doreen" last="Gruber">Doreen Gruber</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Neurology, University of Berlin</s1>
<s3>DEU</s3>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Berlin</wicri:noRegion>
<wicri:noRegion>Department of Neurology, University of Berlin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Neurology, University of Berlin</s1>
<s3>DEU</s3>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Berlin</wicri:noRegion>
<wicri:noRegion>Department of Neurology, University of Berlin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yansheng Du" sort="Yansheng Du" uniqKey="Yansheng Du" last="Yansheng Du">YANSHENG DU</name>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Neurology, Indiana University Medical School</s1>
<s2>Indianapolis, Indiana</s2>
<s3>USA</s3>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Turkheimer, Federico" sort="Turkheimer, Federico" uniqKey="Turkheimer F" first="Federico" last="Turkheimer">Federico Turkheimer</name>
<affiliation wicri:level="3"><inist:fA14 i1="16"><s1>IMRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name>
<affiliation wicri:level="3"><inist:fA14 i1="16"><s1>IMRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Bonn</s1>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>Department of Neurology, University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name>
<affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Department of Neurology, Medical University of Innsbruck</s1>
<s3>AUT</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>European MSA Study Group, Innsbruck Medical University</s1>
<s3>AUT</s3>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>European MSA Study Group, Innsbruck Medical University</wicri:noRegion>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
</author>
<author><name sortKey="Wenning, Gregor" sort="Wenning, Gregor" uniqKey="Wenning G" first="Gregor" last="Wenning">Gregor Wenning</name>
<affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Department of Neurology, Medical University of Innsbruck</s1>
<s3>AUT</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>European MSA Study Group, Innsbruck Medical University</s1>
<s3>AUT</s3>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>European MSA Study Group, Innsbruck Medical University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schade Brittinger, Carmen" sort="Schade Brittinger, Carmen" uniqKey="Schade Brittinger C" first="Carmen" last="Schade-Brittinger">Carmen Schade-Brittinger</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Coordinating Center for Clinical Trials, Philipps-University of Marburg</s1>
<s3>DEU</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Philipps-University of Marburg</wicri:noRegion>
<wicri:noRegion>Coordinating Center for Clinical Trials, Philipps-University of Marburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps-University of Marburg</s1>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Philipps-University of Marburg</wicri:noRegion>
<wicri:noRegion>Department of Neurology, Philipps-University of Marburg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Competence Network Parkinson-Syndrome, Philipps-University of Marburg</s1>
<s3>DEU</s3>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Philipps-University of Marburg</wicri:noRegion>
<wicri:noRegion>Competence Network Parkinson-Syndrome, Philipps-University of Marburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eggert, Karla" sort="Eggert, Karla" uniqKey="Eggert K" first="Karla" last="Eggert">Karla Eggert</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps-University of Marburg</s1>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Philipps-University of Marburg</wicri:noRegion>
<wicri:noRegion>Department of Neurology, Philipps-University of Marburg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Competence Network Parkinson-Syndrome, Philipps-University of Marburg</s1>
<s3>DEU</s3>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Philipps-University of Marburg</wicri:noRegion>
<wicri:noRegion>Competence Network Parkinson-Syndrome, Philipps-University of Marburg</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Emission tomography</term>
<term>Minocycline</term>
<term>Multiple system atrophy</term>
<term>Nervous system diseases</term>
<term>Positron emission tomography</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Atrophie multisystématisée</term>
<term>Pathologie du système nerveux</term>
<term>Minocycline</term>
<term>Traitement</term>
<term>Tomoscintigraphie</term>
<term>Tomographie par émission de positons</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment m patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary outcome variable was the change in the value of the motor score of the Unified Multiple-System-Atrophy Rating-Scale (UMSARSII) from baseline to 48 weeks. Secondary outcome variables included subscores and individual Parkinsonian symptoms as determined by the UMSARS and the Unified-Parkinson's-Disease Rating-Scale (UPDRS). Health-related quality of life (HrQoL) was assessed using the EQ-5D and SF-12. "Progression rate" was assumed to be reflected in the change in motor function over 48 weeks. At 24 weeks and 48 weeks of follow-up, there was a significant deterioration in motor scores in both groups, but neither the change in UMSARSII nor in UPDRSIII differed significantly between treatment groups, i.e. "progression rate" was considered to be similar in both treatment arms. HrQoL did not differ among the two treatment arms. In a small subgroup of patients (n = 8; minocycline = 3, placebo = 5) [<sup>11</sup>
C](R)-PK11195-PET was performed. The three patients in the minocycline group had an attenuated mean increase in microglial activation as compared to the placebo group (P = 0.07) and in two of them individually showed decreased [<sup>11</sup>
C](R)-PK11195 binding actually decreased. These preliminary PET-data suggest that minocycline may interfere with microglial activation. The relevance of this observation requires further investigation. This prospective, 48 week, randomized, double-blind, multinational study failed to show a clinical effect of minocycline on symptom severity as assessed by clinical motor function.</div>
</front>
</TEI>
</INIST>
<ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Minocycline 1‐year therapy in multiple‐system‐atrophy: Effect on clinical symptoms and [11C] (R)‐PK11195 PET (MEMSA‐trial)</title>
<author><name sortKey="Dodel, Richard" sort="Dodel, Richard" uniqKey="Dodel R" first="Richard" last="Dodel">Richard Dodel</name>
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<author><name sortKey="Spottke, Annika" sort="Spottke, Annika" uniqKey="Spottke A" first="Annika" last="Spottke">Annika Spottke</name>
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<author><name sortKey="Gerhard, Alexander" sort="Gerhard, Alexander" uniqKey="Gerhard A" first="Alexander" last="Gerhard">Alexander Gerhard</name>
</author>
<author><name sortKey="Reuss, Alexander" sort="Reuss, Alexander" uniqKey="Reuss A" first="Alexander" last="Reuss">Alexander Reuss</name>
</author>
<author><name sortKey="Reinecker, Sylvia" sort="Reinecker, Sylvia" uniqKey="Reinecker S" first="Sylvia" last="Reinecker">Sylvia Reinecker</name>
</author>
<author><name sortKey="Schimke, Nicole" sort="Schimke, Nicole" uniqKey="Schimke N" first="Nicole" last="Schimke">Nicole Schimke</name>
</author>
<author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name>
</author>
<author><name sortKey="Sixel Ring, Friederike" sort="Sixel Ring, Friederike" uniqKey="Sixel Ring F" first="Friederike" last="Sixel-Döring">Friederike Sixel-Döring</name>
</author>
<author><name sortKey="Herting, Birgit" sort="Herting, Birgit" uniqKey="Herting B" first="Birgit" last="Herting">Birgit Herting</name>
</author>
<author><name sortKey="Kamm, Christoph" sort="Kamm, Christoph" uniqKey="Kamm C" first="Christoph" last="Kamm">Christoph Kamm</name>
</author>
<author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name>
</author>
<author><name sortKey="Sawires, Martin" sort="Sawires, Martin" uniqKey="Sawires M" first="Martin" last="Sawires">Martin Sawires</name>
</author>
<author><name sortKey="Geser, Felix" sort="Geser, Felix" uniqKey="Geser F" first="Felix" last="Geser">Felix Geser</name>
</author>
<author><name sortKey="Kollensperger, Martin" sort="Kollensperger, Martin" uniqKey="Kollensperger M" first="Martin" last="Köllensperger">Martin Köllensperger</name>
</author>
<author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name>
</author>
<author><name sortKey="Kloss, Manja" sort="Kloss, Manja" uniqKey="Kloss M" first="Manja" last="Kloss">Manja Kloss</name>
</author>
<author><name sortKey="Krause, Martin" sort="Krause, Martin" uniqKey="Krause M" first="Martin" last="Krause">Martin Krause</name>
</author>
<author><name sortKey="Daniels, Christine" sort="Daniels, Christine" uniqKey="Daniels C" first="Christine" last="Daniels">Christine Daniels</name>
</author>
<author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name>
</author>
<author><name sortKey="Bottger, Silke" sort="Bottger, Silke" uniqKey="Bottger S" first="Silke" last="Böttger">Silke Böttger</name>
</author>
<author><name sortKey="Naumann, Markus" sort="Naumann, Markus" uniqKey="Naumann M" first="Markus" last="Naumann">Markus Naumann</name>
</author>
<author><name sortKey="Lipp, Axel" sort="Lipp, Axel" uniqKey="Lipp A" first="Axel" last="Lipp">Axel Lipp</name>
</author>
<author><name sortKey="Gruber, Doreen" sort="Gruber, Doreen" uniqKey="Gruber D" first="Doreen" last="Gruber">Doreen Gruber</name>
</author>
<author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name>
</author>
<author><name sortKey="Du, Yansheng" sort="Du, Yansheng" uniqKey="Du Y" first="Yansheng" last="Du">Yansheng Du</name>
</author>
<author><name sortKey="Turkheimer, Federico" sort="Turkheimer, Federico" uniqKey="Turkheimer F" first="Federico" last="Turkheimer">Federico Turkheimer</name>
</author>
<author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name>
</author>
<author><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name>
</author>
<author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name>
<affiliation><country>Autriche</country>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
</author>
<author><name sortKey="Wenning, Gregor" sort="Wenning, Gregor" uniqKey="Wenning G" first="Gregor" last="Wenning">Gregor Wenning</name>
</author>
<author><name sortKey="Schade Rittinger, Carmen" sort="Schade Rittinger, Carmen" uniqKey="Schade Rittinger C" first="Carmen" last="Schade-Brittinger">Carmen Schade-Brittinger</name>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
</author>
<author><name sortKey="Eggert, Karla" sort="Eggert, Karla" uniqKey="Eggert K" first="Karla" last="Eggert">Karla Eggert</name>
</author>
</titleStmt>
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<date when="2010" year="2010">2010</date>
<idno type="doi">10.1002/mds.22732</idno>
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<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Minocycline 1‐year therapy in multiple‐system‐atrophy: Effect on clinical symptoms and [11C] (R)‐PK11195 PET (MEMSA‐trial)</title>
<author><name sortKey="Dodel, Richard" sort="Dodel, Richard" uniqKey="Dodel R" first="Richard" last="Dodel">Richard Dodel</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Philipps‐University of Marburg</wicri:regionArea>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Spottke, Annika" sort="Spottke, Annika" uniqKey="Spottke A" first="Annika" last="Spottke">Annika Spottke</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gerhard, Alexander" sort="Gerhard, Alexander" uniqKey="Gerhard A" first="Alexander" last="Gerhard">Alexander Gerhard</name>
<affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wolfson Molecular Imaging Centre, The University of Manchester</wicri:regionArea>
<placeName><settlement type="city">Manchester</settlement>
<region type="nation">Angleterre</region>
<region nuts="2" type="region">Grand Manchester</region>
</placeName>
<orgName type="university">Université de Manchester</orgName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>IMRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College; London</wicri:regionArea>
<wicri:noRegion>Imperial College; London</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Reuss, Alexander" sort="Reuss, Alexander" uniqKey="Reuss A" first="Alexander" last="Reuss">Alexander Reuss</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Coordinating Center for Clinical Trials, Philipps‐University of Marburg</wicri:regionArea>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Reinecker, Sylvia" sort="Reinecker, Sylvia" uniqKey="Reinecker S" first="Sylvia" last="Reinecker">Sylvia Reinecker</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Coordinating Center for Clinical Trials, Philipps‐University of Marburg</wicri:regionArea>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schimke, Nicole" sort="Schimke, Nicole" uniqKey="Schimke N" first="Nicole" last="Schimke">Nicole Schimke</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Philipps‐University of Marburg</wicri:regionArea>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Paracelsus‐Elena‐Clinic Kassel</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sixel Ring, Friederike" sort="Sixel Ring, Friederike" uniqKey="Sixel Ring F" first="Friederike" last="Sixel-Döring">Friederike Sixel-Döring</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Paracelsus‐Elena‐Clinic Kassel</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Herting, Birgit" sort="Herting, Birgit" uniqKey="Herting B" first="Birgit" last="Herting">Birgit Herting</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Dresden University of Technology</wicri:regionArea>
<wicri:noRegion>Dresden University of Technology</wicri:noRegion>
<wicri:noRegion>Dresden University of Technology</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kamm, Christoph" sort="Kamm, Christoph" uniqKey="Kamm C" first="Christoph" last="Kamm">Christoph Kamm</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hertie‐Institute, University of Tübingen</wicri:regionArea>
<wicri:noRegion>University of Tübingen</wicri:noRegion>
<wicri:noRegion>University of Tübingen</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Rostock</wicri:regionArea>
<wicri:noRegion>University of Rostock</wicri:noRegion>
<wicri:noRegion>University of Rostock</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hertie‐Institute, University of Tübingen</wicri:regionArea>
<wicri:noRegion>University of Tübingen</wicri:noRegion>
<wicri:noRegion>University of Tübingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sawires, Martin" sort="Sawires, Martin" uniqKey="Sawires M" first="Martin" last="Sawires">Martin Sawires</name>
<affiliation wicri:level="4"><country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University of Innsbruck</wicri:regionArea>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
</author>
<author><name sortKey="Geser, Felix" sort="Geser, Felix" uniqKey="Geser F" first="Felix" last="Geser">Felix Geser</name>
<affiliation wicri:level="4"><country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University of Innsbruck</wicri:regionArea>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Autriche</country>
<wicri:regionArea>European MSA Study Group, Innsbruck Medical University</wicri:regionArea>
<wicri:noRegion>Innsbruck Medical University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kollensperger, Martin" sort="Kollensperger, Martin" uniqKey="Kollensperger M" first="Martin" last="Köllensperger">Martin Köllensperger</name>
<affiliation wicri:level="4"><country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University of Innsbruck</wicri:regionArea>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
</author>
<author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name>
<affiliation wicri:level="4"><country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University of Innsbruck</wicri:regionArea>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Autriche</country>
<wicri:regionArea>European MSA Study Group, Innsbruck Medical University</wicri:regionArea>
<wicri:noRegion>Innsbruck Medical University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kloss, Manja" sort="Kloss, Manja" uniqKey="Kloss M" first="Manja" last="Kloss">Manja Kloss</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Heidelberg</wicri:regionArea>
<wicri:noRegion>University of Heidelberg</wicri:noRegion>
<wicri:noRegion>University of Heidelberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Krause, Martin" sort="Krause, Martin" uniqKey="Krause M" first="Martin" last="Krause">Martin Krause</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Heidelberg</wicri:regionArea>
<wicri:noRegion>University of Heidelberg</wicri:noRegion>
<wicri:noRegion>University of Heidelberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Daniels, Christine" sort="Daniels, Christine" uniqKey="Daniels C" first="Christine" last="Daniels">Christine Daniels</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Kiel</wicri:regionArea>
<wicri:noRegion>University of Kiel</wicri:noRegion>
<wicri:noRegion>University of Kiel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Kiel</wicri:regionArea>
<wicri:noRegion>University of Kiel</wicri:noRegion>
<wicri:noRegion>University of Kiel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bottger, Silke" sort="Bottger, Silke" uniqKey="Bottger S" first="Silke" last="Böttger">Silke Böttger</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Würzburg</wicri:regionArea>
<wicri:noRegion>University of Würzburg</wicri:noRegion>
<wicri:noRegion>University of Würzburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Naumann, Markus" sort="Naumann, Markus" uniqKey="Naumann M" first="Markus" last="Naumann">Markus Naumann</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Würzburg</wicri:regionArea>
<wicri:noRegion>University of Würzburg</wicri:noRegion>
<wicri:noRegion>University of Würzburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lipp, Axel" sort="Lipp, Axel" uniqKey="Lipp A" first="Axel" last="Lipp">Axel Lipp</name>
<affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wolfson Molecular Imaging Centre, The University of Manchester</wicri:regionArea>
<placeName><settlement type="city">Manchester</settlement>
<region type="nation">Angleterre</region>
<region nuts="2" type="region">Grand Manchester</region>
</placeName>
<orgName type="university">Université de Manchester</orgName>
</affiliation>
</author>
<author><name sortKey="Gruber, Doreen" sort="Gruber, Doreen" uniqKey="Gruber D" first="Doreen" last="Gruber">Doreen Gruber</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Berlin</wicri:regionArea>
<wicri:noRegion>University of Berlin</wicri:noRegion>
<wicri:noRegion>University of Berlin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Berlin</wicri:regionArea>
<wicri:noRegion>University of Berlin</wicri:noRegion>
<wicri:noRegion>University of Berlin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Du, Yansheng" sort="Du, Yansheng" uniqKey="Du Y" first="Yansheng" last="Du">Yansheng Du</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Indiana University Medical School, Indianapolis, Indiana</wicri:regionArea>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Turkheimer, Federico" sort="Turkheimer, Federico" uniqKey="Turkheimer F" first="Federico" last="Turkheimer">Federico Turkheimer</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>IMRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College; London</wicri:regionArea>
<wicri:noRegion>Imperial College; London</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>IMRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College; London</wicri:regionArea>
<wicri:noRegion>Imperial College; London</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name>
<affiliation wicri:level="4"><country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University of Innsbruck</wicri:regionArea>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Autriche</country>
<wicri:regionArea>European MSA Study Group, Innsbruck Medical University</wicri:regionArea>
<wicri:noRegion>Innsbruck Medical University</wicri:noRegion>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
</author>
<author><name sortKey="Wenning, Gregor" sort="Wenning, Gregor" uniqKey="Wenning G" first="Gregor" last="Wenning">Gregor Wenning</name>
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<wicri:regionArea>Department of Neurology, Medical University of Innsbruck</wicri:regionArea>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Autriche</country>
<wicri:regionArea>European MSA Study Group, Innsbruck Medical University</wicri:regionArea>
<wicri:noRegion>Innsbruck Medical University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schade Rittinger, Carmen" sort="Schade Rittinger, Carmen" uniqKey="Schade Rittinger C" first="Carmen" last="Schade-Brittinger">Carmen Schade-Brittinger</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Coordinating Center for Clinical Trials, Philipps‐University of Marburg</wicri:regionArea>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
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</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Philipps‐University of Marburg</wicri:regionArea>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Competence Network Parkinson‐Syndrome, Philipps‐University of Marburg</wicri:regionArea>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eggert, Karla" sort="Eggert, Karla" uniqKey="Eggert K" first="Karla" last="Eggert">Karla Eggert</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Philipps‐University of Marburg</wicri:regionArea>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Competence Network Parkinson‐Syndrome, Philipps‐University of Marburg</wicri:regionArea>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
<wicri:noRegion>Philipps‐University of Marburg</wicri:noRegion>
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<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2010-01-15">2010-01-15</date>
<biblScope unit="vol">25</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="97">97</biblScope>
<biblScope unit="page" to="107">107</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">7E3C331E554F887479122609783881EAE1EEE31D</idno>
<idno type="DOI">10.1002/mds.22732</idno>
<idno type="ArticleID">MDS22732</idno>
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<seriesStmt><idno type="ISSN">0885-3185</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Isoquinolines (diagnostic use)</term>
<term>Magnetic Resonance Imaging (methods)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Minocycline (therapeutic use)</term>
<term>Multiple System Atrophy (drug therapy)</term>
<term>Multiple System Atrophy (psychology)</term>
<term>Multiple System Atrophy (radionuclide imaging)</term>
<term>Neuroprotective Agents (therapeutic use)</term>
<term>PET</term>
<term>Positron-Emission Tomography (methods)</term>
<term>Quality of Life</term>
<term>Severity of Illness Index</term>
<term>Statistics, Nonparametric</term>
<term>Time Factors</term>
<term>Treatment Outcome</term>
<term>minocycline</term>
<term>multiple system atrophy</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Isoquinolines</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Multiple System Atrophy</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term>
<term>Positron-Emission Tomography</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Multiple System Atrophy</term>
</keywords>
<keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Multiple System Atrophy</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Minocycline</term>
<term>Neuroprotective Agents</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Quality of Life</term>
<term>Severity of Illness Index</term>
<term>Statistics, Nonparametric</term>
<term>Time Factors</term>
<term>Treatment Outcome</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
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<front><div type="abstract" xml:lang="en">The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple‐System‐Atrophy Parkinson‐type (MSA‐P). Sixty‐three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary outcome variable was the change in the value of the motor score of the Unified Multiple‐System‐Atrophy Rating‐Scale (UMSARSII) from baseline to 48 weeks. Secondary outcome variables included subscores and individual Parkinsonian symptoms as determined by the UMSARS and the Unified‐Parkinson's‐Disease Rating‐Scale (UPDRS). Health‐related quality of life (HrQoL) was assessed using the EQ‐5D and SF‐12. “Progression rate” was assumed to be reflected in the change in motor function over 48 weeks. At 24 weeks and 48 weeks of follow‐up, there was a significant deterioration in motor scores in both groups, but neither the change in UMSARSII nor in UPDRSIII differed significantly between treatment groups, i.e. “progression rate” was considered to be similar in both treatment arms. HrQoL did not differ among the two treatment arms. In a small subgroup of patients (n = 8; minocycline = 3, placebo = 5)[11C](R)‐PK11195‐PET was performed. The three patients in the minocycline group had an attenuated mean increase in microglial activation as compared to the placebo group (P = 0.07) and in two of them individually showed decreased [11C](R)‐PK11195 binding actually decreased. These preliminary PET‐data suggest that minocycline may interfere with microglial activation. The relevance of this observation requires further investigation. This prospective, 48 week, randomized, double‐blind, multinational study failed to show a clinical effect of minocycline on symptom severity as assessed by clinical motor function. © 2009 Movement Disorder Society</div>
</front>
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